Having established spheroid models faithfully recapitulate tissue, we demonstrated their utility using
@dviousmind.bsky.social novel TIRE-Seq protocol. We show time & concentration-dependent AC-like state increases after TMZ exposure in a separate PDN model (3/4) www.biorxiv.org/content/10.1...

At the genomic, epigenomic, and transcriptomic level, we observe that the biggest differences between samples is due to patient, not model type. Neither organoids nor spheroids consistently outperform the other in recapitulating tissue (2/4)

Now on BioRxiv: we explored patient-derived GBM organoids & spheroids generated from the same resected tissue. Critically, both models maintain tumor cell composition & heterogeneity, with comparable tissue resemblance across data modalities (1/4)
www.biorxiv.org/content/10.1...