Just out in @jtoonline.bsky.social !

First-line treatment with #BRAF/#MEK targeted therapy or with (chemo)-immunotherapy results in similar survival outcomes in #BRAF-V600 mutated #NSCLC patients.
#LCSM

www.jto.org/article/S155...

FDA approves a rare novel–novel oncology combination that pairs a first-in-class FAK inhibitor with a MEK–RAF glue inhibitor
www.nature.com/articles/d41...

Verastem’s new therapy for a form of KRAS-mutated ovarian cancer combines the kinase inhibitors defactinib and avutometinib

#BRAF V600E detection and effective BRAF/MEKi treatment in a pure epithelioid #mesothelioma upon progression on ICI (biphasic MPM at baseline).

www.jtocrr.org/article/S266...

The April (and #AACR25) issue of Cancer Discovery is now online! The cover features work by Ling Cai, Nia Hammond, @faubert.bsky.social, @rjdlab.bsky.social & colleagues showing high glucose contribution to the TCA cycle is a feature of aggressive NSCLC - more here: aacrjournals.org/cancerdiscov...

If you’re not angry
you’re not paying attention
#LungCancer #lcsm

Quick shout-out on these two collaborative networks (#BOLERO
and #COALA) during my presentation at #ELCC25.

Looking forward to advancing basic and translational research on #BRAF-mutant #NSCLC and other oncogene-driven #NSCLC.

x.com/JulienMazier...

MARIPOSA final OS analysis

❇️ Significant HR 0.75
❇️ 9% 3yr benefit
❇️ Projected mOS 4 years
❇️ Longer control of CNS disease

❗️At the cost of toxicity
❗️No data on duration of toxicity
❗️PROM and QoL data important

More effective than Osimertinib
Most suitable for higher risk pts

#ELCC25

Three days of great science at the #EACR meeting on #persister cells. We presented our work on models of therapy-residual disease in #BRAF-mutant lung cancer.
Great to have part of the #COALA and #BOLERO crowds in Lyon !

@helloeacr.bsky.social
@ocalvayrac.bsky.social
@maraverlab.bsky.social

Resistance to BRAFi + MEKi in #BRAF V600E melanoma patients is driven by activation of focal adhesion signaling.
Avutometinib (RAF-MEK clamp)
in combination with FAKi reverts resistance to BRAFi plus MEKi or to immunotherapy.
dlvr.it/TJFQ3d

Impressive talk by Lise Mangiante
on tissue ecology from ER+ breast cancer. #CRCL25
www.nature.com/articles/s41...

Great kick-off of the #CRCL25 symposium with a keynote lecture by Joan Massague, on metastasis initiation.
www.crclsymposium2025.fr/en/program/d...