Sandeep Kumar
@sandpkr.bsky.social
Postdoc Yale University | PhD Princeton University | Neuroscience, C. elegans, sensorimotor processing
Reposted by Sandeep Kumar
Functional probing of neuronal subtypes via intersectional expression of optogenetic actuators reveals non-linear components in a linear circuit
Functional probing of neuronal subtypes via intersectional expression of optogenetic actuators reveals non-linear components in a linear circuit
Li and Kumar et al. created strains expressing Chrimson in specific TRN subtypes and conducted high-throughput behavioral analysis after optogenetically activating them singly or in combination. They found that although the entire touch circuit integrates opposing stimuli linearly, this balance is lost if only part of the circuit is activated.
dlvr.it
October 2, 2025 at 11:24 PM
Functional probing of neuronal subtypes via intersectional expression of optogenetic actuators reveals non-linear components in a linear circuit
Reposted by Sandeep Kumar
Interested in metabolism? So are we! My lab has been exploring the cell biology of energy metabolism in the nervous system, and we are looking for postdocs. Cool sensors and microscopy, great work environment. Please help me spread the word!
October 2, 2025 at 12:15 AM
Interested in metabolism? So are we! My lab has been exploring the cell biology of energy metabolism in the nervous system, and we are looking for postdocs. Cool sensors and microscopy, great work environment. Please help me spread the word!
Reposted by Sandeep Kumar
Hard to overstate how pleased I am that the FlyWire consortium converted our FAFB ("Full Adult Fly Brain") EM volume into a connectome, and that the resulting science has been (and will be) so impactful. Thanks to everyone involved. #neuroscience www.nature.com/immersive/d4...
The FlyWire connectome: neuronal wiring diagram of a complete fly brain
Artificial intelligence and human expertise meet to generate a map of all the connections in the fly brain. The resource is already being used by experimentalists and theoreticians to further our unde...
www.nature.com
October 2, 2024 at 7:08 PM
Hard to overstate how pleased I am that the FlyWire consortium converted our FAFB ("Full Adult Fly Brain") EM volume into a connectome, and that the resulting science has been (and will be) so impactful. Thanks to everyone involved. #neuroscience www.nature.com/immersive/d4...
Reposted by Sandeep Kumar
The dataset includes ~160,000 cells, segmented nuclei and mitochondria, synapses and neurotransmitter predictions, and annotations linking the CNS to peripheral sensory, motor, and visceral systems.
Info: banc.community
Data: codex.flywire.ai?dataset=banc
Viewer: ng.banc.community/view
Info: banc.community
Data: codex.flywire.ai?dataset=banc
Viewer: ng.banc.community/view
August 3, 2025 at 3:16 PM
The dataset includes ~160,000 cells, segmented nuclei and mitochondria, synapses and neurotransmitter predictions, and annotations linking the CNS to peripheral sensory, motor, and visceral systems.
Info: banc.community
Data: codex.flywire.ai?dataset=banc
Viewer: ng.banc.community/view
Info: banc.community
Data: codex.flywire.ai?dataset=banc
Viewer: ng.banc.community/view
Reposted by Sandeep Kumar
The BANC is the first connectome that explicitly links the brain to the nerve cord, & through it, to the body. It offers a new “embodied” perspective for connectomes, one that changes how we think about neural networks for control, behavior, & even artificial intelligence.
bsky.app/profile/mott...
bsky.app/profile/mott...
I think the "embodiment" of this connectome is going to be such a hit: For instance take the interactive "body part" maps on Codex, where you can simply click on your favorite external or visceral part and it will show you all of the neurons associated it! codex.flywire.ai/app/body_par...
August 3, 2025 at 3:16 PM
The BANC is the first connectome that explicitly links the brain to the nerve cord, & through it, to the body. It offers a new “embodied” perspective for connectomes, one that changes how we think about neural networks for control, behavior, & even artificial intelligence.
bsky.app/profile/mott...
bsky.app/profile/mott...
Reposted by Sandeep Kumar
How is the nervous system organized to coordinate behavior? To approach this massive question, a team led by @asbates.bsky.social, @jasper-tms.bsky.social, @mindyisminsu.bsky.social, & Helen Yang present the BANC: a Brain and Nerve Cord connectome.
Preprint: doi.org/10.1101/2025...
🧪#Neuroskyence
Preprint: doi.org/10.1101/2025...
🧪#Neuroskyence
August 3, 2025 at 3:16 PM
How is the nervous system organized to coordinate behavior? To approach this massive question, a team led by @asbates.bsky.social, @jasper-tms.bsky.social, @mindyisminsu.bsky.social, & Helen Yang present the BANC: a Brain and Nerve Cord connectome.
Preprint: doi.org/10.1101/2025...
🧪#Neuroskyence
Preprint: doi.org/10.1101/2025...
🧪#Neuroskyence
Reposted by Sandeep Kumar
I think the "embodiment" of this connectome is going to be such a hit: For instance take the interactive "body part" maps on Codex, where you can simply click on your favorite external or visceral part and it will show you all of the neurons associated it! codex.flywire.ai/app/body_par...
August 1, 2025 at 10:41 PM
I think the "embodiment" of this connectome is going to be such a hit: For instance take the interactive "body part" maps on Codex, where you can simply click on your favorite external or visceral part and it will show you all of the neurons associated it! codex.flywire.ai/app/body_par...
Reposted by Sandeep Kumar
The first full central nervous system connectome dataset of an adult fly, with the most comprehensive annotation of sensory and motor neurons to date.
A heroic effort with contributions from many groups, a product of the collaborative spirit of the Drosophila neuroscience community.
A heroic effort with contributions from many groups, a product of the collaborative spirit of the Drosophila neuroscience community.
Happy Friday! The female adult fly brain-and-nerve-cord (BANC) connectome is now LIVE!
Explore the data here: codex.flywire.ai?dataset=banc
Check out the preprint here: doi.org/10.1101/2025...
Explore the data here: codex.flywire.ai?dataset=banc
Check out the preprint here: doi.org/10.1101/2025...
a man with a mustache in a blue suit says tiny celebration in front of a group of people
ALT: a man with a mustache in a blue suit says tiny celebration in front of a group of people
media.tenor.com
August 1, 2025 at 11:14 PM
The first full central nervous system connectome dataset of an adult fly, with the most comprehensive annotation of sensory and motor neurons to date.
A heroic effort with contributions from many groups, a product of the collaborative spirit of the Drosophila neuroscience community.
A heroic effort with contributions from many groups, a product of the collaborative spirit of the Drosophila neuroscience community.
Reposted by Sandeep Kumar
Happy Friday! The female adult fly brain-and-nerve-cord (BANC) connectome is now LIVE!
Explore the data here: codex.flywire.ai?dataset=banc
Check out the preprint here: doi.org/10.1101/2025...
Explore the data here: codex.flywire.ai?dataset=banc
Check out the preprint here: doi.org/10.1101/2025...
a man with a mustache in a blue suit says tiny celebration in front of a group of people
ALT: a man with a mustache in a blue suit says tiny celebration in front of a group of people
media.tenor.com
August 1, 2025 at 10:22 PM
Happy Friday! The female adult fly brain-and-nerve-cord (BANC) connectome is now LIVE!
Explore the data here: codex.flywire.ai?dataset=banc
Check out the preprint here: doi.org/10.1101/2025...
Explore the data here: codex.flywire.ai?dataset=banc
Check out the preprint here: doi.org/10.1101/2025...
Reposted by Sandeep Kumar
Public access to the first fly connectome that spans the whole CNS - BANC!: codex.flywire.ai?dataset=banc
Different from prior connectomes - it is brain + cord (think spinal cord)
We use it to ‘embody’ the system and find it resembles ‘subsumption architecture’ doi.org/10.1101/2025...
Different from prior connectomes - it is brain + cord (think spinal cord)
We use it to ‘embody’ the system and find it resembles ‘subsumption architecture’ doi.org/10.1101/2025...
August 2, 2025 at 2:30 PM
Public access to the first fly connectome that spans the whole CNS - BANC!: codex.flywire.ai?dataset=banc
Different from prior connectomes - it is brain + cord (think spinal cord)
We use it to ‘embody’ the system and find it resembles ‘subsumption architecture’ doi.org/10.1101/2025...
Different from prior connectomes - it is brain + cord (think spinal cord)
We use it to ‘embody’ the system and find it resembles ‘subsumption architecture’ doi.org/10.1101/2025...
Reposted by Sandeep Kumar
How does our brain predict the future? Our review of predictive processing + research program is now on arXiv arxiv.org/abs/2504.09614
50+ neuroscientists distributed across the world worked together to create this unique community project.
50+ neuroscientists distributed across the world worked together to create this unique community project.
April 15, 2025 at 6:58 AM
How does our brain predict the future? Our review of predictive processing + research program is now on arXiv arxiv.org/abs/2504.09614
50+ neuroscientists distributed across the world worked together to create this unique community project.
50+ neuroscientists distributed across the world worked together to create this unique community project.