Sabrina Schmied
sabrinaschmied.bsky.social
Sabrina Schmied
@sabrinaschmied.bsky.social
Ph.D. student in Protein Chemistry @univie.ac.at in the Becker Lab
Reposted by Sabrina Schmied
I am extremely happy to share this new @biorxivpreprint.bsky.social, which after a long wait updates our previous preprint.
Thanks to main drivers @bgless.bsky.social and @benjaminsb.bsky.social as well as all involved colleagues and collaborators!

www.biorxiv.org/content/10.1...
January 31, 2025 at 9:58 AM
Reposted by Sabrina Schmied
I am delighted to share that this paper is now published as an Editor's Choice article in JACS Au @pubs.acs.org

pubs.acs.org/doi/10.1021/...
January 11, 2025 at 7:32 AM
Reposted by Sabrina Schmied
I'm excited to share our latest paper reporting an interesting thioester-to-imide acyl transfer reaction of S-acylcysteine.

It was great working with @sabrinaschmied.bsky.social and @christianaolsen.bsky.social

#chemsky #chembio

pubs.acs.org/doi/10.1021/...
Peptide Backbone Cleavage and Transamidation via Thioester-to-Imide Acyl Transfer
Cysteine thioesters are involved in a myriad of central biological transformations due to their unique reactivity. Despite their well-studied properties, we discovered an unexpected transamidation rea...
pubs.acs.org
January 10, 2025 at 2:29 PM
Reposted by Sabrina Schmied
In a new preprint @chemrxiv.bsky.social, work from @bgless.bsky.social and Sabrina Schmied investigate the mechanism of a rearrangement that can lead to peptide/protein backbone cleavage.

Thanks to #LEOFondet for funding the project that led to this discovery.

chemrxiv.org/engage/chemr...
Peptide Backbone Cleavage and trans-Amidation via Thioester-to-Imide Acyl Transfer
Cysteine thioesters are involved in a myriad of cen-tral biological transformations because of their unique reactivity. Despite their well-studied proper-ties, we discovered an unexpected trans-amidat...
chemrxiv.org
December 6, 2024 at 12:52 PM