🔍 For the thesis internal layout, we used zoomed-in areas of the drawing to illustrate the beginning of each chapter, so that the detail could be appreciated.

Can't wait to hold the physical copy in my hands!
#PhDthesis #Anatomy #Lungs #Proefschrift #ThesisLayout

✏️ I've immersed myself in the intricate patterns of the bronchial tree, and using dots to bring volume and depth to the illustration. It was a beautiful (and intense) experience!

🔄 2. A graphical abstract on the transmission pathways.

🔗Check out the paper
@microbiologysociety.org: www.microbiologyresearch.org/content/jour...

#Ebola #GraphicalAbstract #Microbiology #SciArt

The landscape is inspired by Davide's passion for travelling to mountains and remote places.

Can't wait to see the printed book! 📘

📩 Do you want a personalised #PhDcover reflecting your unique journey? Get in touch!

#PhDthesis #CoverIllustration #SciArt

💧 #Neurovascular dysfunction is represented by rivers flowing between brain ridges, sprouting capillary beds as trees, with capCAA deposits along the banks.
🔥 #Neuroinflammation appears as swollen brain regions, erupting lipid mediators and pro-inflammatory factors.

3️⃣ After (many) iterations, we landed on the final cover. A symbolic landscape with many layers.
✨ Stars illuminate exciting discoveries happening below, forming constellations shaped like key research elements (SnaiI gene, #microglia, #DNA repair).

2️⃣ Once I find the right visual metaphor, I start sketching ✏️

#WIP #Brain #SciArt

1️⃣ I like to start with a mind map 🧠 What are the key concepts? How can I visually represent them?

#MindMap #Brain #NeuroInflammation #Alzheimers #BBB

🔚 That’s a wrap! What caught your attention in May’s brain barrier research? 🧠✨
#Neuroimmunology #BrainBarriers #Tcells #CNS #Neuroscience #SciComm (11/11)

🔗 By @leonsmyth.bsky.social & @jonykipnis.bsky.social at Nature Reviews Immunology: www.nature.com/articles/s41...
(10/11)

3️⃣ 𝙍𝙚𝙙𝙚𝙛𝙞𝙣𝙞𝙣𝙜 𝘾𝙉𝙎 𝙞𝙢𝙢𝙪𝙣𝙚 𝙥𝙧𝙞𝙫𝙞𝙡𝙚𝙜𝙚
• This review walks us through the historical concept of immune privilege and its modern redefinition.
• There’s a continuous conversation between immune system and brain, especially at the borders: meninges, ChP, vasculature and CNS-associated bone marrow.
(9/11)

• These T cells are primed by the gut microbiome and influenced by the gut and fat, from which they migrate to the brain.
🔗 By Tomomi Yoshida et al in @nature.com:‬ www.nature.com/articles/s41...
(8/11)

• Researchers found that T cells reside in the subfornical organ of healthy mouse and human brains, and they are distinct from those in the meninges.
(7/11)

2️⃣ 𝘽𝙧𝙖𝙞𝙣 𝙧𝙚𝙨𝙞𝙙𝙚𝙣𝙩 𝙏 𝙘𝙚𝙡𝙡𝙨: 𝙜𝙪𝙩-𝙥𝙧𝙞𝙢𝙚𝙙 𝙏 𝙘𝙚𝙡𝙡𝙨 𝙧𝙚𝙡𝙤𝙘𝙖𝙩𝙚 𝙩𝙤 𝙩𝙝𝙚 𝙘𝙚𝙣𝙩𝙧𝙚 𝙤𝙛 𝙩𝙝𝙚 𝙗𝙧𝙖𝙞𝙣
• This study is actually about a brain region that 𝗹𝗮𝗰𝗸𝘀 a BBB (a circumventricular organ) called the subfornical organ.
#BBB #Immunology (6/11)

🔗 By J. Pareja et al in Acta Neuropathologica Communications: actaneurocomms.biomedcentral.com/articles/10....
(5/11)

• This suggests that JAM-B facilitates CD8 T cell migration across the glia limitans.
• Therapeutically targeting JAM-B in neuroinflammation could help preserve immune surveillance at the brain borders.
#Neuroinflammation (4/11)

• Although JAM-B is expressed at BBB, it wasn’t required for T cell migration across it. Instead, CD8 T cells got stuck in the perivascular space in JAM-B-deficient mice.
• JAM-B also found in other CNS borders: meningeal fibroblasts, choroid plexus epithelium, Bergman glia, and astrocytes. (3/11)

1️⃣ 𝙏𝙧𝙖𝙥𝙥𝙚𝙙 𝙖𝙩 𝙩𝙝𝙚 𝙗𝙤𝙧𝙙𝙚𝙧𝙨: 𝙬𝙞𝙩𝙝𝙤𝙪𝙩 𝙅𝘼𝙈-𝘽, 𝙏 𝙘𝙚𝙡𝙡𝙨 𝙘𝙖𝙣’𝙩 𝙘𝙧𝙤𝙨𝙨 𝙩𝙝𝙚 𝙜𝙡𝙞𝙖 𝙡𝙞𝙢𝙞𝙩𝙖𝙣𝙨
• Loss of JAM-B reduced CD8 T cell infiltration into the CNS parenchyma and led to milder autoimmune neuroinflammation.
#Tcells #Glia (2/11)