Saba Valadkhan
@saba-valadkhan.bsky.social
RNA scientist @CWRU- transcriptomics, long non-coding RNAs, HIV, breast cancer
Pinned
Excited to share our new manuscript in @NatureMicrobiol
uncovering a novel mechanism by which viruses orchestrate their survival in the host. We show that #HIV inherently induces the formation of a latent reservoir of viruses, guaranteeing its long-term survival in the host 🧵 #HIVresearch
uncovering a novel mechanism by which viruses orchestrate their survival in the host. We show that #HIV inherently induces the formation of a latent reservoir of viruses, guaranteeing its long-term survival in the host 🧵 #HIVresearch
Excited to share our new manuscript in @NatureMicrobiol
uncovering a novel mechanism by which viruses orchestrate their survival in the host. We show that #HIV inherently induces the formation of a latent reservoir of viruses, guaranteeing its long-term survival in the host 🧵 #HIVresearch
uncovering a novel mechanism by which viruses orchestrate their survival in the host. We show that #HIV inherently induces the formation of a latent reservoir of viruses, guaranteeing its long-term survival in the host 🧵 #HIVresearch
October 21, 2025 at 7:40 PM
Excited to share our new manuscript in @NatureMicrobiol
uncovering a novel mechanism by which viruses orchestrate their survival in the host. We show that #HIV inherently induces the formation of a latent reservoir of viruses, guaranteeing its long-term survival in the host 🧵 #HIVresearch
uncovering a novel mechanism by which viruses orchestrate their survival in the host. We show that #HIV inherently induces the formation of a latent reservoir of viruses, guaranteeing its long-term survival in the host 🧵 #HIVresearch
Reposted by Saba Valadkhan
HIV Reprograms CD4+ T Cells for Latency
In a landmark study published in Nature Microbiology, researchers have unveiled a revolutionary insight into the enigmatic interplay between HIV and the immune system's CD4+ T cells. The team led by Plasek Hegde and colleagues has elucidated a novel…
In a landmark study published in Nature Microbiology, researchers have unveiled a revolutionary insight into the enigmatic interplay between HIV and the immune system's CD4+ T cells. The team led by Plasek Hegde and colleagues has elucidated a novel…
HIV Reprograms CD4+ T Cells for Latency
In a landmark study published in Nature Microbiology, researchers have unveiled a revolutionary insight into the enigmatic interplay between HIV and the immune system's CD4+ T cells. The team led by Plasek Hegde and colleagues has elucidated a novel mechanism by which HIV commandeers the cellular machinery of these critical immune cells, reprogramming them into a state of profound quiescence and facilitating their entry into proviral latency.
scienmag.com
September 26, 2025 at 11:15 AM
HIV Reprograms CD4+ T Cells for Latency
In a landmark study published in Nature Microbiology, researchers have unveiled a revolutionary insight into the enigmatic interplay between HIV and the immune system's CD4+ T cells. The team led by Plasek Hegde and colleagues has elucidated a novel…
In a landmark study published in Nature Microbiology, researchers have unveiled a revolutionary insight into the enigmatic interplay between HIV and the immune system's CD4+ T cells. The team led by Plasek Hegde and colleagues has elucidated a novel…
Reposted by Saba Valadkhan
#HIV infection reprogrammes CD4+ T cells for quiescence and entry into proviral latency www.nature.com/articles/s41... (open access) @natmicrobiol.nature.com
HIV infection reprogrammes CD4+ T cells for quiescence and entry into proviral latency - Nature Microbiology
HIV infection triggers transcriptomic remodelling and a quiescence programme via KLF2 and the p53 pathway leading to proviral silencing.
www.nature.com
September 29, 2025 at 12:38 PM
#HIV infection reprogrammes CD4+ T cells for quiescence and entry into proviral latency www.nature.com/articles/s41... (open access) @natmicrobiol.nature.com
Reposted by Saba Valadkhan
Our lncRNA-in-brain review is out in @natrevneuro.nature.com
✨ The emerging roles of long noncoding RNAs in the brain
We discuss 🧬 lncRNA roles in brain development, synaptic function, learning, & behavior
💡 Therapeutic potential and future directions.
@unswrna.bsky.social @unswbabs.bsky.social
✨ The emerging roles of long noncoding RNAs in the brain
We discuss 🧬 lncRNA roles in brain development, synaptic function, learning, & behavior
💡 Therapeutic potential and future directions.
@unswrna.bsky.social @unswbabs.bsky.social
September 5, 2025 at 11:41 PM
Our lncRNA-in-brain review is out in @natrevneuro.nature.com
✨ The emerging roles of long noncoding RNAs in the brain
We discuss 🧬 lncRNA roles in brain development, synaptic function, learning, & behavior
💡 Therapeutic potential and future directions.
@unswrna.bsky.social @unswbabs.bsky.social
✨ The emerging roles of long noncoding RNAs in the brain
We discuss 🧬 lncRNA roles in brain development, synaptic function, learning, & behavior
💡 Therapeutic potential and future directions.
@unswrna.bsky.social @unswbabs.bsky.social
Reposted by Saba Valadkhan
#NewResearch
HIV infection triggers transcriptomic remodelling and a quiescence programme via KLF2 and the p53 pathway leading to proviral silencing.
#MicroSky 🦠
www.nature.com/articles/s41...
HIV infection triggers transcriptomic remodelling and a quiescence programme via KLF2 and the p53 pathway leading to proviral silencing.
#MicroSky 🦠
www.nature.com/articles/s41...
HIV infection reprogrammes CD4+ T cells for quiescence and entry into proviral latency - Nature Microbiology
HIV infection triggers transcriptomic remodelling and a quiescence programme via KLF2 and the p53 pathway leading to proviral silencing.
www.nature.com
October 1, 2025 at 5:41 PM
#NewResearch
HIV infection triggers transcriptomic remodelling and a quiescence programme via KLF2 and the p53 pathway leading to proviral silencing.
#MicroSky 🦠
www.nature.com/articles/s41...
HIV infection triggers transcriptomic remodelling and a quiescence programme via KLF2 and the p53 pathway leading to proviral silencing.
#MicroSky 🦠
www.nature.com/articles/s41...
Reposted by Saba Valadkhan
HIV infection of CD4 T cells drives KLF2 and p53 signaling, which downregulate MYC and proliferation pathways, resulting in proviral transcriptional silencing to enhance latent reservoir formation @natmicrobiol.nature.com @saba-valadkhan.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
September 26, 2025 at 4:43 PM
HIV infection of CD4 T cells drives KLF2 and p53 signaling, which downregulate MYC and proliferation pathways, resulting in proviral transcriptional silencing to enhance latent reservoir formation @natmicrobiol.nature.com @saba-valadkhan.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...