🫶🫶🫶

Okay, only if you bring me a bracelet!

But is this an open invite? 😹

Can I have one?!

Tim Kwok @uoftrheum.bsky.social on D2T gout, focusing on equity and who needs to get uricase based therapies

The D2T concept started with RA, has taken hold of axSpA and PsA, and now gout enters the chat

#GCAN2025 #ACR25

BUT CLOAK, a colchicine in knee OA RCT was negative.

Are we asking the wrong Q? Do we need a long duration on colchicine to detect tx benefit?

LoDoCo2 posthoc: colchicine reduced risk of jt replacement

#GCAN2025 #ACR25

OA & gout: both related to chronic low level inflammation thru IL-1b

Urate levels have been a/w OA progression & higher synovial fluid IL-1b levels in OA knees

Is there benefit of colchicine in knee OA?

#GCAN2025 #ACR25

⭐Ben Hemming - UAB

More on gout & CVD: recurrent MSU crystal injection induces macrophage protective tolerance. Studied in vivo (mice) and in vitro.

#GCAN2025 #ACR25

⭐Daniel Ward Phillips - UAB

Focus on gout & CVD: how does inflammation from MSU crystals cause ASCVD?

Studied in mice: fed a Western diet and injected with MSU crystals

Unique inflam response from EMP1+ macrophage-like monocytes

#GCAN2025 #ACR25

Dr. Jason Yang: In STOP Gout, achieving SU < 6 mg/dL was linked to flares with lower pain intensity and shorter duration (esp. in pts w/o tophi). Flare characteristics may serve as early indicators of ULT efficacy beyond flare counts.
#2025GCAN #Gout #Rheumatology