Thang Le, PharmD, MBA, BCPS, RPh
@rxthangle.bsky.social
Exploring rheumatology, bridging research & practice. Unraveling autoimmune mysteries. ☕ & pun lover 🥸, advocating patient care. Views are my own.
Gout goes beyond joints.
Dr. Jasvinder Singh presents data linking gout to higher risks of myocardial infarction, vascular events, and atrial fibrillation, even when accounting for common comorbidities.
Emerging evidence reinforces gout as a systemic disease impacting cardiovascular health. #ACR25
Dr. Jasvinder Singh presents data linking gout to higher risks of myocardial infarction, vascular events, and atrial fibrillation, even when accounting for common comorbidities.
Emerging evidence reinforces gout as a systemic disease impacting cardiovascular health. #ACR25
October 27, 2025 at 2:00 PM
Gout goes beyond joints.
Dr. Jasvinder Singh presents data linking gout to higher risks of myocardial infarction, vascular events, and atrial fibrillation, even when accounting for common comorbidities.
Emerging evidence reinforces gout as a systemic disease impacting cardiovascular health. #ACR25
Dr. Jasvinder Singh presents data linking gout to higher risks of myocardial infarction, vascular events, and atrial fibrillation, even when accounting for common comorbidities.
Emerging evidence reinforces gout as a systemic disease impacting cardiovascular health. #ACR25
@natalie-mccor.bsky.social summarized that over half of people with gout also have metabolic syndrome, with insulin resistance driving hyperuricemia through reduced renal excretion. Lifestyle changes like weight loss and lower fructose intake can improve both gout and metabolic outcomes. #ACR25
October 27, 2025 at 1:39 PM
@natalie-mccor.bsky.social summarized that over half of people with gout also have metabolic syndrome, with insulin resistance driving hyperuricemia through reduced renal excretion. Lifestyle changes like weight loss and lower fructose intake can improve both gout and metabolic outcomes. #ACR25
Dr. Natalie McCormick adds how insulin resistance drives gout via decreased renal urate clearance. Elevated insulin enhances urate reabsorption through URAT1 and other transporters, linking metabolic dysfunction to hyperuricemia and gout risk. #ACR25
October 27, 2025 at 1:31 PM
Dr. Natalie McCormick adds how insulin resistance drives gout via decreased renal urate clearance. Elevated insulin enhances urate reabsorption through URAT1 and other transporters, linking metabolic dysfunction to hyperuricemia and gout risk. #ACR25
Dr. Natalie McCormick discusses how insulin resistance drives gout through both urate overproduction and underexcretion. Fructose intake plays a key role, rapidly increasing uric acid synthesis and gout risk with higher dietary consumption. #Gout #MetabolicSyndrome #ACR25
October 27, 2025 at 1:27 PM
Dr. Natalie McCormick discusses how insulin resistance drives gout through both urate overproduction and underexcretion. Fructose intake plays a key role, rapidly increasing uric acid synthesis and gout risk with higher dietary consumption. #Gout #MetabolicSyndrome #ACR25
Dr. Natalie McCormick highlights that serum urate levels are strongly linked to metabolic syndrome burden. Hyperuricemia may serve as a surrogate marker of metabolic risk, suggesting urate could be considered a 6th MetS criterion. #ACR25
October 27, 2025 at 1:18 PM
Dr. Natalie McCormick highlights that serum urate levels are strongly linked to metabolic syndrome burden. Hyperuricemia may serve as a surrogate marker of metabolic risk, suggesting urate could be considered a 6th MetS criterion. #ACR25
Live from #ACR25- Dr. Natalie McCormick is discussing the link between metabolic syndrome and gout, highlighting how insulin resistance and inflammation contribute to disease burden and outcomes.
October 27, 2025 at 1:12 PM
Live from #ACR25- Dr. Natalie McCormick is discussing the link between metabolic syndrome and gout, highlighting how insulin resistance and inflammation contribute to disease burden and outcomes.
Dr. Angelo Gaffo emphasized that gout diagnosis relies on clinical presentation, serum urate, and imaging when available. Crystal confirmation is ideal but not always required. Context and tools matter. #ACR25 #gout #rheumatology
October 25, 2025 at 4:36 PM
Dr. Angelo Gaffo emphasized that gout diagnosis relies on clinical presentation, serum urate, and imaging when available. Crystal confirmation is ideal but not always required. Context and tools matter. #ACR25 #gout #rheumatology
At #ACR25, Dr. Angelo Gaffo emphasized that serum urate can guide gout diagnosis, but timing matters. Levels often decrease during acute flares, underscoring the need for clinical context in interpreting sUA. #Gout #Rheumatology
October 25, 2025 at 4:30 PM
At #ACR25, Dr. Angelo Gaffo emphasized that serum urate can guide gout diagnosis, but timing matters. Levels often decrease during acute flares, underscoring the need for clinical context in interpreting sUA. #Gout #Rheumatology
Dr. Tim Kwok emphasized that “difficult-to-treat gout” goes beyond urate levels, involving persistent inflammation, reduced function, and higher healthcare use. A holistic approach addressing clinical, patient, and system factors is key. #2025GCAN #Gout #Rheumatology
October 22, 2025 at 9:47 PM
Dr. Tim Kwok emphasized that “difficult-to-treat gout” goes beyond urate levels, involving persistent inflammation, reduced function, and higher healthcare use. A holistic approach addressing clinical, patient, and system factors is key. #2025GCAN #Gout #Rheumatology
Reposted by Thang Le, PharmD, MBA, BCPS, RPh
Tim Kwok @uoftrheum.bsky.social on D2T gout, focusing on equity and who needs to get uricase based therapies
The D2T concept started with RA, has taken hold of axSpA and PsA, and now gout enters the chat
#GCAN2025 #ACR25
The D2T concept started with RA, has taken hold of axSpA and PsA, and now gout enters the chat
#GCAN2025 #ACR25
October 22, 2025 at 9:28 PM
Tim Kwok @uoftrheum.bsky.social on D2T gout, focusing on equity and who needs to get uricase based therapies
The D2T concept started with RA, has taken hold of axSpA and PsA, and now gout enters the chat
#GCAN2025 #ACR25
The D2T concept started with RA, has taken hold of axSpA and PsA, and now gout enters the chat
#GCAN2025 #ACR25
Dr. Michael Pillinger: Colchicine continues to show potential CV benefits in gout. Cipolletta et al. found lower short-term MI/stroke risk with colchicine during ULT initiation (HR 0.72). Yokose et al. showed colchicine safer than NSAIDs, though not vs placebo.
#2025GCAN #Gout #Cardiology
#2025GCAN #Gout #Cardiology
October 22, 2025 at 6:38 PM
Dr. Michael Pillinger: Colchicine continues to show potential CV benefits in gout. Cipolletta et al. found lower short-term MI/stroke risk with colchicine during ULT initiation (HR 0.72). Yokose et al. showed colchicine safer than NSAIDs, though not vs placebo.
#2025GCAN #Gout #Cardiology
#2025GCAN #Gout #Cardiology
Reposted by Thang Le, PharmD, MBA, BCPS, RPh
In the STOP Gout trial, 77% of pts achieved SU <6 mg/dL at or below the EasyAllo2-predicted allopurinol dose. Younger age, lower eGFR, and higher SU required higher doses, supporting EasyAllo2 for guided dose escalation.
Dr. Brian Coburn #2025GCAN #Gout #Rheumatology
Dr. Brian Coburn #2025GCAN #Gout #Rheumatology
October 22, 2025 at 4:19 PM
In the STOP Gout trial, 77% of pts achieved SU <6 mg/dL at or below the EasyAllo2-predicted allopurinol dose. Younger age, lower eGFR, and higher SU required higher doses, supporting EasyAllo2 for guided dose escalation.
Dr. Brian Coburn #2025GCAN #Gout #Rheumatology
Dr. Brian Coburn #2025GCAN #Gout #Rheumatology
Dr. Hyon Choi presents new data supporting treat-to-target urate lowering in gout.
In a 10-year cohort (n=3,613), 95% of flares occurred with SU ≥6 mg/dL and 98% with SU ≥5 mg/dL. Flare rates rose sharply as SU increased, reinforcing the <6 mg/dL goal.
#2025GCAN #Gout #Rheumatology
In a 10-year cohort (n=3,613), 95% of flares occurred with SU ≥6 mg/dL and 98% with SU ≥5 mg/dL. Flare rates rose sharply as SU increased, reinforcing the <6 mg/dL goal.
#2025GCAN #Gout #Rheumatology
October 22, 2025 at 3:05 PM
Dr. Hyon Choi presents new data supporting treat-to-target urate lowering in gout.
In a 10-year cohort (n=3,613), 95% of flares occurred with SU ≥6 mg/dL and 98% with SU ≥5 mg/dL. Flare rates rose sharply as SU increased, reinforcing the <6 mg/dL goal.
#2025GCAN #Gout #Rheumatology
In a 10-year cohort (n=3,613), 95% of flares occurred with SU ≥6 mg/dL and 98% with SU ≥5 mg/dL. Flare rates rose sharply as SU increased, reinforcing the <6 mg/dL goal.
#2025GCAN #Gout #Rheumatology
AI is advancing crystal disease diagnosis.
Deep learning models can now detect CPPD on hand radiographs, and machine learning of Raman spectra enables point-of-care identification of gout and CPPD.
Dr. Geraldine McCarthy #2025GCAN #Rheumatology #AIinMedicine
Deep learning models can now detect CPPD on hand radiographs, and machine learning of Raman spectra enables point-of-care identification of gout and CPPD.
Dr. Geraldine McCarthy #2025GCAN #Rheumatology #AIinMedicine
October 22, 2025 at 2:56 PM
AI is advancing crystal disease diagnosis.
Deep learning models can now detect CPPD on hand radiographs, and machine learning of Raman spectra enables point-of-care identification of gout and CPPD.
Dr. Geraldine McCarthy #2025GCAN #Rheumatology #AIinMedicine
Deep learning models can now detect CPPD on hand radiographs, and machine learning of Raman spectra enables point-of-care identification of gout and CPPD.
Dr. Geraldine McCarthy #2025GCAN #Rheumatology #AIinMedicine
In a national VA cohort (18,761 CPPD pts, 75,043 controls), nephrolithiasis prevalence was higher in CPPD (8.6% vs 5.1%). Adjusted OR 1.65 supports CPPD as an independent risk factor for kidney stones and a systemic mineralization disorder.
Dr. Geraldine McCarthy #2025GCAN #Rheumatology
Dr. Geraldine McCarthy #2025GCAN #Rheumatology
October 22, 2025 at 2:50 PM
In a national VA cohort (18,761 CPPD pts, 75,043 controls), nephrolithiasis prevalence was higher in CPPD (8.6% vs 5.1%). Adjusted OR 1.65 supports CPPD as an independent risk factor for kidney stones and a systemic mineralization disorder.
Dr. Geraldine McCarthy #2025GCAN #Rheumatology
Dr. Geraldine McCarthy #2025GCAN #Rheumatology
In >20,000 matched patients aged ≥60, CPPD was linked to a 29% higher risk of any fracture across spine and limb sites over 85,000 patient-years. Risk was consistent in both men and women, supporting bone health screening in CPPD.
Dr. Geraldine McCarthy #2025GCAN #Rheumatology
Dr. Geraldine McCarthy #2025GCAN #Rheumatology
October 22, 2025 at 2:49 PM
In >20,000 matched patients aged ≥60, CPPD was linked to a 29% higher risk of any fracture across spine and limb sites over 85,000 patient-years. Risk was consistent in both men and women, supporting bone health screening in CPPD.
Dr. Geraldine McCarthy #2025GCAN #Rheumatology
Dr. Geraldine McCarthy #2025GCAN #Rheumatology
In a Mass General Brigham cohort (1991–2022), 756 CPPD patients had higher 10-year ASCVD risk scores vs matched controls, despite similar CAC burden. Findings suggest factors beyond CAC contribute to elevated CV risk in CPPD.
Dr. Geraldine McCarthy #2025GCAN #Rheumatology
Dr. Geraldine McCarthy #2025GCAN #Rheumatology
October 22, 2025 at 2:47 PM
In a Mass General Brigham cohort (1991–2022), 756 CPPD patients had higher 10-year ASCVD risk scores vs matched controls, despite similar CAC burden. Findings suggest factors beyond CAC contribute to elevated CV risk in CPPD.
Dr. Geraldine McCarthy #2025GCAN #Rheumatology
Dr. Geraldine McCarthy #2025GCAN #Rheumatology
From 20-year and 7-year cohort data, chondrocalcinosis was present in 5% at baseline and linked to higher odds of incident knee OA (OR 1.75). No consistent association with knee pain. CC may represent a distinct OA subtype.
Dr. Geraldine McCarthy #2025GCAN #Rheumatology
Dr. Geraldine McCarthy #2025GCAN #Rheumatology
October 22, 2025 at 2:45 PM
From 20-year and 7-year cohort data, chondrocalcinosis was present in 5% at baseline and linked to higher odds of incident knee OA (OR 1.75). No consistent association with knee pain. CC may represent a distinct OA subtype.
Dr. Geraldine McCarthy #2025GCAN #Rheumatology
Dr. Geraldine McCarthy #2025GCAN #Rheumatology
In 51 patients with OA, ultrasound outperformed radiography for detecting CPPD (accuracy 0.78 vs 0.73). Combining both modalities added value only in select cases. US alone was more reliable for CPPD identification.
Dr. Geraldine McCarthy #2025GCAN #Rheumatology
Dr. Geraldine McCarthy #2025GCAN #Rheumatology
October 22, 2025 at 2:43 PM
In 51 patients with OA, ultrasound outperformed radiography for detecting CPPD (accuracy 0.78 vs 0.73). Combining both modalities added value only in select cases. US alone was more reliable for CPPD identification.
Dr. Geraldine McCarthy #2025GCAN #Rheumatology
Dr. Geraldine McCarthy #2025GCAN #Rheumatology