Reto
@rts1997.bsky.social
Currently doing one more experiment :)
PhD student @ETH in the group of Barbara Treutlein (D-BSSE) 🧠
Former MSc student @Biozentrum in the group of @RichardNeher 🦠
PhD student @ETH in the group of Barbara Treutlein (D-BSSE) 🧠
Former MSc student @Biozentrum in the group of @RichardNeher 🦠
Reposted by Reto
🧬🔍How can enhancers achieve tissue-specific activity?
We use MPRAs of synthetic enhancers to derive interpretable rules on TFBS arrangement 🚦 and discover that negative synergies drive specificity in hematopoiesis 🩸. Shoutout to @Robert Frömel & @larsplus.bsky.social for leading this work 🦹🦸.
We use MPRAs of synthetic enhancers to derive interpretable rules on TFBS arrangement 🚦 and discover that negative synergies drive specificity in hematopoiesis 🩸. Shoutout to @Robert Frömel & @larsplus.bsky.social for leading this work 🦹🦸.
Out in Cell @cp-cell.bsky.social: Design principles of cell-state-specific enhancers in hematopoiesis
🧬🩸 screen of fully synthetic enhancers in blood progenitors
🤖 AI that creates new cell state specific enhancers
🔍 negative synergies between TFs lead to specificity!
www.cell.com/cell/fulltex...
🧵
🧬🩸 screen of fully synthetic enhancers in blood progenitors
🤖 AI that creates new cell state specific enhancers
🔍 negative synergies between TFs lead to specificity!
www.cell.com/cell/fulltex...
🧵
Design principles of cell-state-specific enhancers in hematopoiesis
Screen of minimalistic enhancers in blood progenitor cells demonstrates widespread
dual activator-repressor function of transcription factors (TFs) and enables the model-guided
design of cell-state-sp...
www.cell.com
May 9, 2025 at 6:39 AM
🧬🔍How can enhancers achieve tissue-specific activity?
We use MPRAs of synthetic enhancers to derive interpretable rules on TFBS arrangement 🚦 and discover that negative synergies drive specificity in hematopoiesis 🩸. Shoutout to @Robert Frömel & @larsplus.bsky.social for leading this work 🦹🦸.
We use MPRAs of synthetic enhancers to derive interpretable rules on TFBS arrangement 🚦 and discover that negative synergies drive specificity in hematopoiesis 🩸. Shoutout to @Robert Frömel & @larsplus.bsky.social for leading this work 🦹🦸.
Reposted by Reto
Happy to share our resource for blood vessel organoids!
@zhisonghe.bsky.social, Makiko Seimiya, Gustav Jonsson, Wuji Cao, Ryo Okuda, Reiner Wimmer, Ryoko Okamoto
Barbara Treutlein, @graycamplab.bsky.social, @penningerlab.bsky.social
@zhisonghe.bsky.social, Makiko Seimiya, Gustav Jonsson, Wuji Cao, Ryo Okuda, Reiner Wimmer, Ryoko Okamoto
Barbara Treutlein, @graycamplab.bsky.social, @penningerlab.bsky.social
Now online! Fate and state transitions during human blood vessel organoid development
Fate and state transitions during human blood vessel organoid development
Single-cell multiomic reconstruction of the human blood vessel organoid system allows for classifying and modeling disease and cell-type-specific states, demonstrating its potential for translational research.
dlvr.it
April 21, 2025 at 6:39 PM
Happy to share our resource for blood vessel organoids!
@zhisonghe.bsky.social, Makiko Seimiya, Gustav Jonsson, Wuji Cao, Ryo Okuda, Reiner Wimmer, Ryoko Okamoto
Barbara Treutlein, @graycamplab.bsky.social, @penningerlab.bsky.social
@zhisonghe.bsky.social, Makiko Seimiya, Gustav Jonsson, Wuji Cao, Ryo Okuda, Reiner Wimmer, Ryoko Okamoto
Barbara Treutlein, @graycamplab.bsky.social, @penningerlab.bsky.social
Reposted by Reto
Thrilled to announce that our work (w. with fantastic @neher.io and Liam Shaw) has been published on Molecular Biology and Evolution! 🎉
academic.oup.com/mbe/advance-...
Are you curious about how fast the genome of E.coli evolves structurally (gains, rearrangements...) ? 🧬
A summary thread [1/N]🧵
academic.oup.com/mbe/advance-...
Are you curious about how fast the genome of E.coli evolves structurally (gains, rearrangements...) ? 🧬
A summary thread [1/N]🧵
Quantifying the evolutionary dynamics of structure and content in closely-related E. coli genomes
Abstract. Bacterial genomes primarily diversify via gain, loss, and rearrangement of genetic material in their flexible accessory genome. Yet the dynamics
academic.oup.com
January 6, 2025 at 5:12 PM
Thrilled to announce that our work (w. with fantastic @neher.io and Liam Shaw) has been published on Molecular Biology and Evolution! 🎉
academic.oup.com/mbe/advance-...
Are you curious about how fast the genome of E.coli evolves structurally (gains, rearrangements...) ? 🧬
A summary thread [1/N]🧵
academic.oup.com/mbe/advance-...
Are you curious about how fast the genome of E.coli evolves structurally (gains, rearrangements...) ? 🧬
A summary thread [1/N]🧵