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rosscloney.bsky.social
ross
@rosscloney.bsky.social
350 followers 50 following 120 posts
Chief Editor for Biotechnology at Nature Communications. This is gonna be mostly science, sometimes other stuff. All views my own. he/him
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rosscloney.bsky.social
Sucrose-driven carbon redox rebalancing eliminates the Crabtree effect and boosts energy metabolism in yeast

www.nature.com/articles/s41...
Sucrose-driven carbon redox rebalancing eliminates the Crabtree effect and boosts energy metabolism in yeast - Nature Communications
The Crabtree effect affects yeast-based bioproduction. Here, the authors report the development of a Crabtree-negative yeast through introducing the sucrose phosphorolysis pathway, deletion of the pho...
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June 27, 2025 at 9:10 AM
rosscloney.bsky.social
Spatially blocked split CRISPR-Cas12a system for ultra-sensitive and versatile small molecule activation and detection

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Spatially blocked split CRISPR-Cas12a system for ultra-sensitive and versatile small molecule activation and detection - Nature Communications
Detecting small molecules is pivotal across many fields. Here, authors leverage a split crRNA mode to construct spatially blocked split CRISPR-Cas12a system. This approach establishes a low-background...
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June 27, 2025 at 9:10 AM
rosscloney.bsky.social
Precision multiplexed base editing in human cells using Cas12a-derived base editors

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Precision multiplexed base editing in human cells using Cas12a-derived base editors - Nature Communications
Current base editors cannot simultaneously edit multiple loci with base-pair level precision, hindering complex genotype generation. Here the authors describe optimized Cas12a gRNA array designs, enab...
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June 27, 2025 at 9:10 AM
rosscloney.bsky.social
Circular RNA-mediated inverse prime editing in human cells

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Circular RNA-mediated inverse prime editing in human cells - Nature Communications
Prime editors are restricted to performing precise edits downstream of cleavage sites. Here, authors develop helicase-assisted circular RNA-mediated inverse PEs (ciPEs) to increase editing efficiencie...
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June 27, 2025 at 9:10 AM
rosscloney.bsky.social
Feedback-responsive cell factories for dynamic modulation of the unfolded protein response

www.nature.com/articles/s41...
Feedback-responsive cell factories for dynamic modulation of the unfolded protein response - Nature Communications
Engineering cell factories that support the production of large quantities of protein therapeutics remains a significant biomanufacturing challenge. Here the authors engineered cells to sense an early...
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May 30, 2025 at 12:53 PM
rosscloney.bsky.social
Generative and predictive neural networks for the design of functional RNA molecules

www.nature.com/articles/s41...
Generative and predictive neural networks for the design of functional RNA molecules - Nature Communications
Designing high performance RNA molecules is a unifying challenge across many areas of biotechnology research. Here, authors develop GARDN and SANDSTORM, a data-efficient generative AI framework for de...
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May 30, 2025 at 12:53 PM
rosscloney.bsky.social
A chimeric viral platform for directed evolution in mammalian cells

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A chimeric viral platform for directed evolution in mammalian cells - Nature Communications
Directed evolution is a process of mutation and artificial selection to breed biomolecules with new or improved activity. Here the authors develop a directed evolution platform (PROTein Evolution Usin...
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May 30, 2025 at 12:53 PM
rosscloney.bsky.social
Designer artificial environments for membrane protein synthesis

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Designer artificial environments for membrane protein synthesis - Nature Communications
Membrane proteins are notoriously difficult to synthesize. Here, authors introduce MEMPLEX, a high-throughput experimentation platform guided by machine learning that designs artificial cell-free envi...
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May 30, 2025 at 12:53 PM
rosscloney.bsky.social
A generalizable approach for programming protease-responsive conformationally inhibited artificial transcriptional factors

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A generalizable approach for programming protease-responsive conformationally inhibited artificial transcriptional factors - Nature Communications
Artificial transcription factors (ATFs) are core elements of customized circuits responsible for signal output and event transformation. Here, the authors report the design of a protease-responsive co...
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May 30, 2025 at 12:53 PM
rosscloney.bsky.social
Directed evolution of aminoacyl-tRNA synthetases through in vivo hypermutation

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Directed evolution of aminoacyl-tRNA synthetases through in vivo hypermutation - Nature Communications
Genetic code expansion (GCE) enables the incorporation of new amino acids into proteins. Here, authors demonstrate the rapid OrthoRep-driven evolution of aminoacyl-tRNA synthetases for GCE, increasing...
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May 30, 2025 at 12:53 PM
rosscloney.bsky.social
Expanded ribosomal synthesis of non-standard cyclic backbones in vitro

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Expanded ribosomal synthesis of non-standard cyclic backbones in vitro - Nature Communications
The ribosome has evolved to link standard amino acids into proteins via peptide bonds. Here, authors expand its chemistry to directly synthesize novel 5- and 6- membered cyclic backbones from noncanon...
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May 30, 2025 at 12:53 PM
rosscloney.bsky.social
Construction of multi-targeted CRISPR libraries in tomato to overcome functional redundancy at genome-scale level

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Construction of multi-targeted CRISPR libraries in tomato to overcome functional redundancy at genome-scale level - Nature Communications
Genetic variance is vital for breeding programs and mutant screening, yet traditional mutagenesis methods wrestle with genetic redundancy and a lack of specificity in gene targeting. Here the authors ...
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May 30, 2025 at 12:53 PM
rosscloney.bsky.social
Dual inhibition of DNA-PK and Polϴ boosts precision of diverse prime editing systems

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Dual inhibition of DNA-PK and Polϴ boosts precision of diverse prime editing systems - Nature Communications
Prime editing can generate undesired editing outcomes. Here, authors describe a method for reducing both on-target and off-target imprecise editing outcomes of diverse prime editing modalities in diff...
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May 30, 2025 at 12:53 PM
rosscloney.bsky.social
A CRISPR/Cas9-based enhancement of high-throughput single-cell transcriptomics

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A CRISPR/Cas9-based enhancement of high-throughput single-cell transcriptomics - Nature Communications
Single-cell RNAseq can struggle to capture cellular heterogeneity due to the relatively low expression of biologically meaningful transcripts. Here the authors present an approach called scCLEAN, whic...
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May 30, 2025 at 12:53 PM
rosscloney.bsky.social
Elucidating the genetic mechanisms governing cytosine base editing outcomes through CRISPRi screens

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Elucidating the genetic mechanisms governing cytosine base editing outcomes through CRISPRi screens - Nature Communications
Cytosine base editors use an uracil-containing intermediate to introduce C•G to T•A and C•G to G•C point mutations. Here, the authors couple gene knockdown with reporters of these two cytosine base ed...
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May 30, 2025 at 12:53 PM
rosscloney.bsky.social
Genetically encoded fluorescent reporter for polyamines

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Genetically encoded fluorescent reporter for polyamines - Nature Communications
Polyamines are essential metabolites linked to aging, cancer, and Parkinson’s disease. Here, authors develop a live-cell polyamine reporter and use a genome-wide CRISPR screen to uncover a link betwee...
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May 30, 2025 at 12:53 PM
rosscloney.bsky.social
Design of diverse, functional mitochondrial targeting sequences across eukaryotic organisms using variational autoencoder

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Design of diverse, functional mitochondrial targeting sequences across eukaryotic organisms using variational autoencoder - Nature Communications
Mitochondria play a key role in cellular metabolism. Here, authors develop a Variational Autoencoder to design novel mitochondrial targeting sequences, validating them across several eukaryotic organi...
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May 30, 2025 at 12:53 PM
rosscloney.bsky.social
Cost-effective urine recycling enabled by a synthetic osteoyeast platform for production of hydroxyapatite

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Cost-effective urine recycling enabled by a synthetic osteoyeast platform for production of hydroxyapatite - Nature Communications
Upcycling urine in wastewater for nitrogen and phosphorus production has gained attention, but their low market values hamper the application. Here, the authors develop a yeast platform that mimics os...
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May 30, 2025 at 12:53 PM
rosscloney.bsky.social
A megatransposon drives the adaptation of Thermoanaerobacter kivui to carbon monoxide

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A megatransposon drives the adaptation of Thermoanaerobacter kivui to carbon monoxide - Nature Communications
Carbon monoxide (CO) present in syngas severely inhibits growth of many acetogens. Here, the authors adapt, characterize, and engineer utilization of CO as sole carbon and energy source by the thermop...
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May 30, 2025 at 12:53 PM
rosscloney.bsky.social
Regulating triacylglycerol cycling for high-efficiency production of polyunsaturated fatty acids and derivatives

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Regulating triacylglycerol cycling for high-efficiency production of polyunsaturated fatty acids and derivatives - Nature Communications
The authors demonstrate the role and mechanism of triacylglycerol (TAG) cycling in polyunsaturated fatty acid biosynthesis and develop a strategy of decoupling the TAG biosynthesis and degradation to ...
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May 30, 2025 at 12:53 PM
rosscloney.bsky.social
Microbial synthesis of branched-chain β,γ-diols from amino acid metabolism

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Microbial synthesis of branched-chain β,γ-diols from amino acid metabolism - Nature Communications
The position of hydroxyl groups, the carbon number of the alkyl chain, and the modification of the side chain are key factors determining the function of diols. Here, the authors report a biosynthetic...
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May 30, 2025 at 12:53 PM
rosscloney.bsky.social
Modular deregulation of central carbon metabolism for efficient xylose utilization in Saccharomyces cerevisiae

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Modular deregulation of central carbon metabolism for efficient xylose utilization in Saccharomyces cerevisiae - Nature Communications
Here, the authors show that a modular deregulation strategy in Saccharomyces cerevisiae boosts xylose conversion to 3-HP by engineering central carbon metabolism with five strategies, achieving a 4.7-...
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May 30, 2025 at 12:53 PM
rosscloney.bsky.social
Designing pathways for bioproducing complex chemicals by combining tools for pathway extraction and ranking

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Designing pathways for bioproducing complex chemicals by combining tools for pathway extraction and ranking - Nature Communications
Synthesis of complex molecules requires reactions from multiple pathways operating in balanced subnetworks. Here, the authors report a computational algorithm that combines the strength of constraint-...
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May 30, 2025 at 12:53 PM
rosscloney.bsky.social
Economic and sustainable revolution to facilitate one-carbon biomanufacturing

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Engineered microbial platform confers resistance against heavy metals via phosphomelanin biosynthesis - Nature Communications
Heavy metals and plastics are two major environmental pollutants. Here, the authors engineer microbial platforms capable of endogenously biosynthesizing phosphomelanin for simultaneously heavy metals ...
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May 30, 2025 at 12:53 PM