Rolleig
@rolleig.bsky.social
Reposted by Rolleig
Beta-blocker use after myocardial infarction reduces the risk of death in patients with a reduced ejection fraction, but its benefit is less clear in patients without a reduced ejection fraction. Research findings from the REBOOT trial are summarized in a new Quick Take video. nej.md/47Az6rE
November 15, 2025 at 8:00 PM
Beta-blocker use after myocardial infarction reduces the risk of death in patients with a reduced ejection fraction, but its benefit is less clear in patients without a reduced ejection fraction. Research findings from the REBOOT trial are summarized in a new Quick Take video. nej.md/47Az6rE
I'm really tired of shady #GLP1 studies that are nothing but marketing
Single centre retroactive observational study can never establish a nexus of causality, esp with such a wide coinfection interval. Confounded and very weak.
www.tandfonline.com/doi/full/10....
Single centre retroactive observational study can never establish a nexus of causality, esp with such a wide coinfection interval. Confounded and very weak.
www.tandfonline.com/doi/full/10....
The Influence of GLP-1 Receptor Agonists on Five-Year Mortality in Colon Cancer Patients
Colorectal cancer is a leading cause of morbidity and mortality worldwide. This study investigates the association between GLP-1 receptor agonists (GLP-1 RAs) and five-year mortality in patients wi...
www.tandfonline.com
November 15, 2025 at 1:23 PM
I'm really tired of shady #GLP1 studies that are nothing but marketing
Single centre retroactive observational study can never establish a nexus of causality, esp with such a wide coinfection interval. Confounded and very weak.
www.tandfonline.com/doi/full/10....
Single centre retroactive observational study can never establish a nexus of causality, esp with such a wide coinfection interval. Confounded and very weak.
www.tandfonline.com/doi/full/10....
Another PSA screening failure (and study shenanigans). After 23 years follow-up no difference in all cause mortality.
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
October 30, 2025 at 3:13 PM
Another PSA screening failure (and study shenanigans). After 23 years follow-up no difference in all cause mortality.
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
It's said that more 90% of clinical trials are underpowered. #SURPASSCVOT is the latest example.
0.55 to 0.94) and all-cause mortality hazard ratio: 0.61; 95.0% CI: 0.45 to 0.82
These are rather wide CI. A sign of underpower or lousy selection. Looks like pure marketing to me.
0.55 to 0.94) and all-cause mortality hazard ratio: 0.61; 95.0% CI: 0.45 to 0.82
These are rather wide CI. A sign of underpower or lousy selection. Looks like pure marketing to me.
August 1, 2025 at 10:38 AM
It's said that more 90% of clinical trials are underpowered. #SURPASSCVOT is the latest example.
0.55 to 0.94) and all-cause mortality hazard ratio: 0.61; 95.0% CI: 0.45 to 0.82
These are rather wide CI. A sign of underpower or lousy selection. Looks like pure marketing to me.
0.55 to 0.94) and all-cause mortality hazard ratio: 0.61; 95.0% CI: 0.45 to 0.82
These are rather wide CI. A sign of underpower or lousy selection. Looks like pure marketing to me.
Invesrigación necesita formación , tiempo y dinero. Vale la pena el tiempo y dinero invertido? Claro que no.
🔬 Un editorial en la revista 'Atención Primaria' denuncia la falta de incentivos, reconocimiento y apoyo estructural a quienes investigan desde el primer nivel asistencial.
📝 Lee el artículo completo aquí:
www.semfyc.es/actualidad/u...
📝 Lee el artículo completo aquí:
www.semfyc.es/actualidad/u...
July 29, 2025 at 2:00 PM
Invesrigación necesita formación , tiempo y dinero. Vale la pena el tiempo y dinero invertido? Claro que no.
Listening to Peter Thiel intelectual karaoke . Pretentious jargon that the interviewer doesn't dare to question. When you are Peter Theil, it is difficult to have someone call you out on your bullshit.
www.nytimes.com/2025/06/26/o...
www.nytimes.com/2025/06/26/o...
Opinion | Peter Thiel and the Antichrist
www.nytimes.com
July 19, 2025 at 2:50 PM
Listening to Peter Thiel intelectual karaoke . Pretentious jargon that the interviewer doesn't dare to question. When you are Peter Theil, it is difficult to have someone call you out on your bullshit.
www.nytimes.com/2025/06/26/o...
www.nytimes.com/2025/06/26/o...
#SOLOISTWHF is an example of sheermarketing. Enlist a highly diverse cohort of 79% HFrEF and 21% #HfrEF then market the results as positive for HfpEF. A closer look at the CI reveals an imprecise underpowered & completely useless trial. Pure marketing.
July 18, 2025 at 1:29 PM
#SOLOISTWHF is an example of sheermarketing. Enlist a highly diverse cohort of 79% HFrEF and 21% #HfrEF then market the results as positive for HfpEF. A closer look at the CI reveals an imprecise underpowered & completely useless trial. Pure marketing.
Lo de #TorrePacheco tiene un nombre: #pogrom
July 15, 2025 at 5:59 PM
Lo de #TorrePacheco tiene un nombre: #pogrom
Trump is disappointed because Putin is not giving his bluff the attention it deserves.
July 15, 2025 at 5:29 AM
Trump is disappointed because Putin is not giving his bluff the attention it deserves.
This is a good conversation on the attention economy, or better to think of it as the economy of bullshit.
www.nytimes.com/2025/07/08/o...
www.nytimes.com/2025/07/08/o...
Opinion | How the Attention Economy Is Devouring Gen Z — and the Rest of Us
www.nytimes.com
July 10, 2025 at 3:48 PM
This is a good conversation on the attention economy, or better to think of it as the economy of bullshit.
www.nytimes.com/2025/07/08/o...
www.nytimes.com/2025/07/08/o...
Reposted by Rolleig
VKA are safer than DOACs in frail patients. ?Questionable study. DOAC dosis are not reported and Apixaban (most widely used) is only 17% of patients. A real study should be VKA vs Apixaban 2.5mg BID.
www.ahajournals.org/doi/full/10....
www.ahajournals.org/doi/full/10....
Safety of Switching From a Vitamin K Antagonist to a Non–Vitamin K Antagonist Oral Anticoagulant in Frail Older Patients With Atrial Fibrillation: Results of the FRAIL-AF Randomized Controlled Trial |...
BACKGROUND: There is ambiguity whether frail patients with atrial fibrillation managed with vitamin
K antagonists (VKAs) should be switched to a non–vitamin K oral anticoagulant (NOAC). METHODS: We ...
www.ahajournals.org
June 8, 2025 at 11:23 AM
VKA are safer than DOACs in frail patients. ?Questionable study. DOAC dosis are not reported and Apixaban (most widely used) is only 17% of patients. A real study should be VKA vs Apixaban 2.5mg BID.
www.ahajournals.org/doi/full/10....
www.ahajournals.org/doi/full/10....
Does anybody find the Trump-Musk fallout surprising?
June 5, 2025 at 7:47 PM
Does anybody find the Trump-Musk fallout surprising?
Come on America. Trump, Musk and now this guy? Is this is kind of thought you are able to produce lately? Is this the end of American civilization?
www.newyorker.com/magazine/202...
www.newyorker.com/magazine/202...
Curtis Yarvin’s Plot Against America
The reactionary blogger’s call for a monarch to rule the country once seemed like a joke. Now the right is ready to bend the knee.
www.newyorker.com
June 4, 2025 at 11:41 AM
Come on America. Trump, Musk and now this guy? Is this is kind of thought you are able to produce lately? Is this the end of American civilization?
www.newyorker.com/magazine/202...
www.newyorker.com/magazine/202...
"There will be no inflation in 2025" Elon Musk in summer 2024.
May 29, 2025 at 4:53 AM
"There will be no inflation in 2025" Elon Musk in summer 2024.
Reposted by Rolleig
Opinion: What began with a chainsaw is ending in a whimper. Elon Musk’s looming exit from Washington brings the oddest chapter of Donald Trump’s presidency to an early close. By his own metrics, Musk’s so-called Department of Government Efficiency has failed. www.ft.com/content/0c6e...
May 6, 2025 at 12:51 PM
Opinion: What began with a chainsaw is ending in a whimper. Elon Musk’s looming exit from Washington brings the oddest chapter of Donald Trump’s presidency to an early close. By his own metrics, Musk’s so-called Department of Government Efficiency has failed. www.ft.com/content/0c6e...
Cada vez veo más Urbason IM para lumbagos. No sé dónde encontrar este protocolo 🤔
April 15, 2025 at 1:40 PM
Cada vez veo más Urbason IM para lumbagos. No sé dónde encontrar este protocolo 🤔
You can't pretend be a brilliant negotiator when everybody knows you're bluffing.
April 11, 2025 at 2:54 PM
You can't pretend be a brilliant negotiator when everybody knows you're bluffing.
"the tariffs are a gun on the negotiating table — ideally not to be used. For him, the ultimate goal is the devaluation of the dollar. “
UnHerd US
[...]Read More...
unherd.com
April 7, 2025 at 11:12 AM
"the tariffs are a gun on the negotiating table — ideally not to be used. For him, the ultimate goal is the devaluation of the dollar. “
2025 Canada election model
Monitor our forecast to see who is ahead in the race
www.economist.com
April 4, 2025 at 12:04 PM