Many thanks to @danmucida.bsky.social and all our co-authors for their contributions to this work!

We believe these findings provide important insights into how T cells adapt across organs and how tissue cues shape both their function and clonal expansion. We also hope that TRACK mice will be a valuable tool for the scientific community studying T cell dynamics in health and disease.

Interestingly, early clonal segregation during infection evolved into greater inter-organ sharing, leading to clonal equilibrium over time, likely driven by retrograde migration previously reported in CD8 T cells. Additionally, TCR specificity converged on a few viral proteins at the memory stage.

During viral infection, different tissues, including secondary lymphoid organs, not only shape the transcriptional profile of CD4 T cells but also control the expansion of specific clones, likely driven by TCR specificity and each tissue’s unique antigen landscape.

The novel TRACK mice we developed allow us to carefully follow recently activated, antigen-agnostic polyclonal CD4 T cells during perturbations (controlled by tamoxifen) and determine how they are clonally selected and transcriptionally defined across organs.

ICQ !!!

One project is to determine how T cells adapts to various tissue environments and how long this information is stored within the cell. The second project is to develop novel tools to track T cell migration across organs.

Please spread the word! #postdoc #STEMjobs #sciencejobs #czbiohub

Congrats Justin! Amazing work

Here is the commentary published in Cell regarding this topic!

www.cell.com/cell/abstrac...

And as a bonus—the position is based in the heart of New York City! Beyond the exciting scientific opportunities, you’ll have access to the vibrant, culturally rich, and inspiring environment that makes New York such an extraordinary place to live and work.

CZ Biohub NY is affiliated with three powerhouse institutions—The Rockefeller University, Columbia University, and Yale University. This provides opportunities to engage with leading scientists, attend world-class lectures, and access cutting-edge technologies across these institutions.