Roelfes Group
@roelfesgroup.bsky.social
Interdisciplinary group at the University of Groningen @rug.nl working on Artificial Enzymes, Bioorthogonal Catalysis and Chemistry in Living Cells. Posts by group members.
https://sites.google.com/rug.nl/roelfesgroup/
https://sites.google.com/rug.nl/roelfesgroup/
Please also check posters 007 and 257 to find out more about radical biocatalysis and leveraging epistasis efficiently in artificial enzymes, respectively.
@stratinghinst.bsky.social
@stratinghinst.bsky.social
July 1, 2025 at 10:39 AM
Please also check posters 007 and 257 to find out more about radical biocatalysis and leveraging epistasis efficiently in artificial enzymes, respectively.
@stratinghinst.bsky.social
@stratinghinst.bsky.social
Tanja presented her work on metallaphotoredox catalysis in designer photoenzymes.
Congrats to both of you!
@stratinghinst.bsky.social @unigroningen.bsky.social
Congrats to both of you!
@stratinghinst.bsky.social @unigroningen.bsky.social
March 11, 2025 at 7:01 PM
Tanja presented her work on metallaphotoredox catalysis in designer photoenzymes.
Congrats to both of you!
@stratinghinst.bsky.social @unigroningen.bsky.social
Congrats to both of you!
@stratinghinst.bsky.social @unigroningen.bsky.social
This accomplishment would not have been possible without the tireless work of Ru Jiang and @fabricas.bsky.social and the expertise of Andy-Mark Thunnissen in solving the holoenzyme structure.
Great work everyone! 🏆
Great work everyone! 🏆
February 14, 2025 at 2:10 PM
This accomplishment would not have been possible without the tireless work of Ru Jiang and @fabricas.bsky.social and the expertise of Andy-Mark Thunnissen in solving the holoenzyme structure.
Great work everyone! 🏆
Great work everyone! 🏆
Check it out here: onlinelibrary.wiley.com/doi/10.1002/...
An artificial copper‐Michaelase featuring a genetically encoded bipyridine ligand for asymmetric additions to nitroalkenes
Artificial metalloenzymes (ArMs) are an attractive approach to achieving “new to nature” biocatalytic transformations. In this work, a novel copper-dependent artificial Michaelase (Cu_Michaelase) com...
onlinelibrary.wiley.com
February 14, 2025 at 2:10 PM
Check it out here: onlinelibrary.wiley.com/doi/10.1002/...
The excellent properties of the evolved artificial metalloenzyme enabled its application in preparative-scale synthesis, yielding valuable synthons for the production of pharmaceutical compounds.
February 14, 2025 at 2:10 PM
The excellent properties of the evolved artificial metalloenzyme enabled its application in preparative-scale synthesis, yielding valuable synthons for the production of pharmaceutical compounds.
Using a magnetic bead-based assay, we successfully evolved this newly-generated biocatalyst, achieving perfect enantioselectivity and high yields in the asymmetric new-to-nature addition to nitroalkenes.
February 14, 2025 at 2:10 PM
Using a magnetic bead-based assay, we successfully evolved this newly-generated biocatalyst, achieving perfect enantioselectivity and high yields in the asymmetric new-to-nature addition to nitroalkenes.