Robert Tan
@robertt4n.bsky.social
3D genome, chromatin regulation, multi-omic TechDev @ New York Genome Center 🗽, via WEHI 🇦🇺
Reposted by Robert Tan
New work from my lab with the Brown lab on how genome folding changes during motor neuron maturation, and how this process goes awry in ALS motor neurons. Led by Dr. Ozgun Uyan.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Dynamic changes in chromosome and nuclear architecture during maturation of normal and ALS C9orf72 motor neurons
We have investigated changes in chromosome conformation, nuclear organization, and transcription during differentiation and maturation of control and mutant motor neurons harboring hexanucleotide expa...
www.biorxiv.org
September 23, 2025 at 9:13 PM
New work from my lab with the Brown lab on how genome folding changes during motor neuron maturation, and how this process goes awry in ALS motor neurons. Led by Dr. Ozgun Uyan.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Robert Tan
The projected rise in global cancer deaths
1990 —5.9 million
2023—10.4 million
2050—18.8 million
is yet another reason we need to get primary prevention into high gear, which is now possible but not getting done
www.thelancet.com/journals/lan...
1990 —5.9 million
2023—10.4 million
2050—18.8 million
is yet another reason we need to get primary prevention into high gear, which is now possible but not getting done
www.thelancet.com/journals/lan...
September 24, 2025 at 10:38 PM
The projected rise in global cancer deaths
1990 —5.9 million
2023—10.4 million
2050—18.8 million
is yet another reason we need to get primary prevention into high gear, which is now possible but not getting done
www.thelancet.com/journals/lan...
1990 —5.9 million
2023—10.4 million
2050—18.8 million
is yet another reason we need to get primary prevention into high gear, which is now possible but not getting done
www.thelancet.com/journals/lan...
Reposted by Robert Tan
The latest Annual Review of Genomics and Human Genetics is now online 🧬 Most read article so far is "Mechanisms of Enhancer-Mediated Gene Activation in the Context of the 3D Genome" @akispapantonis.bsky.social @mariekeoudelaar.bsky.social Check it out arevie.ws/47BZEJp
Full TOC: arevie.ws/4plCaPe
Full TOC: arevie.ws/4plCaPe
September 9, 2025 at 10:57 PM
The latest Annual Review of Genomics and Human Genetics is now online 🧬 Most read article so far is "Mechanisms of Enhancer-Mediated Gene Activation in the Context of the 3D Genome" @akispapantonis.bsky.social @mariekeoudelaar.bsky.social Check it out arevie.ws/47BZEJp
Full TOC: arevie.ws/4plCaPe
Full TOC: arevie.ws/4plCaPe
Reposted by Robert Tan
Excited to share another new preprint from our lab in which we developed a cluster-based phasing strategy using long read nano-NOMe-seq data to link distinct CTCF binding states—captured at the single molecule level—to the transcriptional status of genes: biorxiv.org/content/10.1...
September 9, 2025 at 5:44 PM
Excited to share another new preprint from our lab in which we developed a cluster-based phasing strategy using long read nano-NOMe-seq data to link distinct CTCF binding states—captured at the single molecule level—to the transcriptional status of genes: biorxiv.org/content/10.1...
Reposted by Robert Tan
EPIGENETIC HULK READY TO SMASH AGAIN! GET IN LOSERS!
June 13, 2025 at 4:30 AM
EPIGENETIC HULK READY TO SMASH AGAIN! GET IN LOSERS!