Robin Hofmeister
@rjhfmstr.bsky.social
Postdoc with Z.Kutalik | research fellow with Lili Milani | Statistical modelling of haplotypes - parent of origin | skier, climber, windsurfer
Curious about the technical details of the parental haplotype reconstruction that powers this assortative mating study? 🧬
Check out our recent @nature.com
paper: www.nature.com/articles/s41...
Check out our recent @nature.com
paper: www.nature.com/articles/s41...
September 26, 2025 at 5:10 PM
Curious about the technical details of the parental haplotype reconstruction that powers this assortative mating study? 🧬
Check out our recent @nature.com
paper: www.nature.com/articles/s41...
Check out our recent @nature.com
paper: www.nature.com/articles/s41...
Big thanks to the amazing team behind this work and funders 🙏
This project was collaborative across Switzerland 🇨🇭, Estonia 🇪🇪, Italy 🇮🇹, and supervised by @zkutalik.bsky.social !
@snsf.ch @unil.bsky.social @fbm-unil.bsky.social
This project was collaborative across Switzerland 🇨🇭, Estonia 🇪🇪, Italy 🇮🇹, and supervised by @zkutalik.bsky.social !
@snsf.ch @unil.bsky.social @fbm-unil.bsky.social
September 26, 2025 at 5:10 PM
Big thanks to the amazing team behind this work and funders 🙏
This project was collaborative across Switzerland 🇨🇭, Estonia 🇪🇪, Italy 🇮🇹, and supervised by @zkutalik.bsky.social !
@snsf.ch @unil.bsky.social @fbm-unil.bsky.social
This project was collaborative across Switzerland 🇨🇭, Estonia 🇪🇪, Italy 🇮🇹, and supervised by @zkutalik.bsky.social !
@snsf.ch @unil.bsky.social @fbm-unil.bsky.social
The big picture: assortative mating has intensified in recent generations.
Especially for height and education.
This means biases in GWAS & downstream analyses are likely stronger in younger cohorts.
Especially for height and education.
This means biases in GWAS & downstream analyses are likely stronger in younger cohorts.
September 26, 2025 at 5:10 PM
The big picture: assortative mating has intensified in recent generations.
Especially for height and education.
This means biases in GWAS & downstream analyses are likely stronger in younger cohorts.
Especially for height and education.
This means biases in GWAS & downstream analyses are likely stronger in younger cohorts.
Most approaches need genotyped couples (rare in biobanks) or rely on long-term signals.
Our haplotype-based method uses our recent inter-chromosomal phasing method to separate maternal & paternal haplotypes, then correlates partial parental polygenic scores to measure assortment.
Our haplotype-based method uses our recent inter-chromosomal phasing method to separate maternal & paternal haplotypes, then correlates partial parental polygenic scores to measure assortment.
September 26, 2025 at 5:10 PM
Most approaches need genotyped couples (rare in biobanks) or rely on long-term signals.
Our haplotype-based method uses our recent inter-chromosomal phasing method to separate maternal & paternal haplotypes, then correlates partial parental polygenic scores to measure assortment.
Our haplotype-based method uses our recent inter-chromosomal phasing method to separate maternal & paternal haplotypes, then correlates partial parental polygenic scores to measure assortment.
Reposted by Robin Hofmeister
Reposted by Robin Hofmeister
Dirigée par @zkutalik.bsky.social et @rjhfmstr.bsky.social à la @fbm-unil.bsky.social, au @sib.swiss et à #unisanté, une nouvelle étude publiée dans @nature.com présente une méthode computationnelle innovante pour étudier ces effets liés à l’origine parentale.
🔗 www.nature.com/articles/s41...
🔗 www.nature.com/articles/s41...
Parent-of-origin effects on complex traits in up to 236,781 individuals - Nature
A novel multistep strategy reveals how parent-of-origin effects shape complex traits in large-scale biobanks.
www.nature.com
August 7, 2025 at 9:42 AM
Dirigée par @zkutalik.bsky.social et @rjhfmstr.bsky.social à la @fbm-unil.bsky.social, au @sib.swiss et à #unisanté, une nouvelle étude publiée dans @nature.com présente une méthode computationnelle innovante pour étudier ces effets liés à l’origine parentale.
🔗 www.nature.com/articles/s41...
🔗 www.nature.com/articles/s41...
Thrilled to see this project come to life — a huge team effort with collaborators in 🇨🇭 🇪🇪 🇳🇴! Huge thanks to all co-authors and funders!
@zkutalik.bsky.social @lilimilani.bsky.social @srubinacci.bsky.social @adriaan-vd-graaf.bsky.social @unil.bsky.social @estbiobank.bsky.social and many more !
@zkutalik.bsky.social @lilimilani.bsky.social @srubinacci.bsky.social @adriaan-vd-graaf.bsky.social @unil.bsky.social @estbiobank.bsky.social and many more !
August 6, 2025 at 6:27 PM
Thrilled to see this project come to life — a huge team effort with collaborators in 🇨🇭 🇪🇪 🇳🇴! Huge thanks to all co-authors and funders!
@zkutalik.bsky.social @lilimilani.bsky.social @srubinacci.bsky.social @adriaan-vd-graaf.bsky.social @unil.bsky.social @estbiobank.bsky.social and many more !
@zkutalik.bsky.social @lilimilani.bsky.social @srubinacci.bsky.social @adriaan-vd-graaf.bsky.social @unil.bsky.social @estbiobank.bsky.social and many more !
The paper comes with:
A Nature Research Briefing 🔗 www.nature.com/articles/d41...
Press releases from our local press:
🔗 www.unil.ch/news/fr/1754...
🔗 www.sib.swiss/fr/news/limp...
Open data & tools for the community :
🔗 rjhfmstr.github.io/THORIN/
A Nature Research Briefing 🔗 www.nature.com/articles/d41...
Press releases from our local press:
🔗 www.unil.ch/news/fr/1754...
🔗 www.sib.swiss/fr/news/limp...
Open data & tools for the community :
🔗 rjhfmstr.github.io/THORIN/
August 6, 2025 at 6:27 PM
The paper comes with:
A Nature Research Briefing 🔗 www.nature.com/articles/d41...
Press releases from our local press:
🔗 www.unil.ch/news/fr/1754...
🔗 www.sib.swiss/fr/news/limp...
Open data & tools for the community :
🔗 rjhfmstr.github.io/THORIN/
A Nature Research Briefing 🔗 www.nature.com/articles/d41...
Press releases from our local press:
🔗 www.unil.ch/news/fr/1754...
🔗 www.sib.swiss/fr/news/limp...
Open data & tools for the community :
🔗 rjhfmstr.github.io/THORIN/
All bi-polar effects involve growth & metabolism, giving one of the strongest evidence yet for the genetic conflict hypothesis ⚔️
This evolutionary “tug-of-war”:
Dad’s genes → push growth
Mom’s genes → limit growth to save resources
This evolutionary “tug-of-war”:
Dad’s genes → push growth
Mom’s genes → limit growth to save resources
August 6, 2025 at 6:27 PM
All bi-polar effects involve growth & metabolism, giving one of the strongest evidence yet for the genetic conflict hypothesis ⚔️
This evolutionary “tug-of-war”:
Dad’s genes → push growth
Mom’s genes → limit growth to save resources
This evolutionary “tug-of-war”:
Dad’s genes → push growth
Mom’s genes → limit growth to save resources
By separating maternal and paternal genomes, we discovered >30 parent-of-origin effects, including bi-polar effects:
➡️ Allele from one parent ↑ trait
➡️ Allele from the other parent ↓ trait
These findings expose a hiding pattern of genetic effect in biobank data.
➡️ Allele from one parent ↑ trait
➡️ Allele from the other parent ↓ trait
These findings expose a hiding pattern of genetic effect in biobank data.
August 6, 2025 at 6:27 PM
By separating maternal and paternal genomes, we discovered >30 parent-of-origin effects, including bi-polar effects:
➡️ Allele from one parent ↑ trait
➡️ Allele from the other parent ↓ trait
These findings expose a hiding pattern of genetic effect in biobank data.
➡️ Allele from one parent ↑ trait
➡️ Allele from the other parent ↓ trait
These findings expose a hiding pattern of genetic effect in biobank data.