Rhys Parry
@rhyshparry.bsky.social
Virologist at the University of Queensland. #virology #virusevolution #rnavirology
New preprint from the Khromykh/ @slonchak.bsky.social /Short lab 👇
In primary human nasal epithelia, #Omicron BA.5 & XBB show enhanced ciliated-cell tropism and a striking cilia-gene shutdown plus apoptosis/inflammation, unlike ancestral virus or BA.1.
Preprint:
www.biorxiv.org/content/10.1...
In primary human nasal epithelia, #Omicron BA.5 & XBB show enhanced ciliated-cell tropism and a striking cilia-gene shutdown plus apoptosis/inflammation, unlike ancestral virus or BA.1.
Preprint:
www.biorxiv.org/content/10.1...
November 21, 2025 at 3:51 AM
New preprint from the Khromykh/ @slonchak.bsky.social /Short lab 👇
In primary human nasal epithelia, #Omicron BA.5 & XBB show enhanced ciliated-cell tropism and a striking cilia-gene shutdown plus apoptosis/inflammation, unlike ancestral virus or BA.1.
Preprint:
www.biorxiv.org/content/10.1...
In primary human nasal epithelia, #Omicron BA.5 & XBB show enhanced ciliated-cell tropism and a striking cilia-gene shutdown plus apoptosis/inflammation, unlike ancestral virus or BA.1.
Preprint:
www.biorxiv.org/content/10.1...
Had a wonderful time at #HCVFLAVI2025 in Singapore presenting our Flavi ncRNA work from the Khromykh lab and was chuffed to pick up a short talk award. Here I am with other awardees demonstrating a normal distribution. Hope to see you again at #HCVFLAVI2026
October 18, 2025 at 6:05 AM
Had a wonderful time at #HCVFLAVI2025 in Singapore presenting our Flavi ncRNA work from the Khromykh lab and was chuffed to pick up a short talk award. Here I am with other awardees demonstrating a normal distribution. Hope to see you again at #HCVFLAVI2026
Final day of #HCFLAVI2025 with a great talk from @maringerlab.bsky.social on 3D models of dengue microvascular dysfunction, using gorgeous liver microvascular spheroids, to unpack #dengue vascular pathology.
October 16, 2025 at 2:07 AM
Final day of #HCFLAVI2025 with a great talk from @maringerlab.bsky.social on 3D models of dengue microvascular dysfunction, using gorgeous liver microvascular spheroids, to unpack #dengue vascular pathology.
Haunted lately by @galaxyproject.bsky.social CO₂e estimates for jobs. This one MEGAHIT assembly: ~450g CO2e. I've run this ~150k times on HPC, ~75 tonnes of CO2e 😬. Perhaps ARC/NHMRC would accept Australian Carbon Credit Units as part of the grant cost for offset? What others are doing in AUS/INT?
October 6, 2025 at 3:55 AM
Haunted lately by @galaxyproject.bsky.social CO₂e estimates for jobs. This one MEGAHIT assembly: ~450g CO2e. I've run this ~150k times on HPC, ~75 tonnes of CO2e 😬. Perhaps ARC/NHMRC would accept Australian Carbon Credit Units as part of the grant cost for offset? What others are doing in AUS/INT?
Congrats to @summabibby.bsky.social @naphakm.bsky.social Daniel Watterson et al. here at SCMB on the first high-res cryo-EM structures of yellow fever virus! Striking vaccine vs virulent particle differences and a single R380 residue shaping antigenicity & neutralisation. doi.org/10.1038/s414...
September 27, 2025 at 3:31 AM
Congrats to @summabibby.bsky.social @naphakm.bsky.social Daniel Watterson et al. here at SCMB on the first high-res cryo-EM structures of yellow fever virus! Striking vaccine vs virulent particle differences and a single R380 residue shaping antigenicity & neutralisation. doi.org/10.1038/s414...
The use of attenuated SC2 JN.1 as a bivalent vaccine vector. Mutate (D130A) in nsp16, delete FCS in spike, delete accessory ORFs, and/or modify transcription regulatory sequences, then add prefusion RSV F. Successfully protects, although modified TRS seem to over-attenuate. doi.org/10.1126/scia...
September 27, 2025 at 3:22 AM
The use of attenuated SC2 JN.1 as a bivalent vaccine vector. Mutate (D130A) in nsp16, delete FCS in spike, delete accessory ORFs, and/or modify transcription regulatory sequences, then add prefusion RSV F. Successfully protects, although modified TRS seem to over-attenuate. doi.org/10.1126/scia...
Establishment of reverse genetics systems for Colorado tick fever virus. Remind me never to complain about monopartite reverse genetics systems.
journals.plos.org/plospathogen...
journals.plos.org/plospathogen...
September 25, 2025 at 6:34 AM
Establishment of reverse genetics systems for Colorado tick fever virus. Remind me never to complain about monopartite reverse genetics systems.
journals.plos.org/plospathogen...
journals.plos.org/plospathogen...
Impressive work on the effect of #Wolbachia in 60! strains of DENV. Like earlier reports, DENV-1,2,4 was strongly inhibited. DENV-3 isolates had more variable & weaker inhibition.
Given the range of genotypes, this is a strong foundation to examine viral genetic determinants of susceptibility.
Given the range of genotypes, this is a strong foundation to examine viral genetic determinants of susceptibility.
September 22, 2025 at 1:43 AM
Impressive work on the effect of #Wolbachia in 60! strains of DENV. Like earlier reports, DENV-1,2,4 was strongly inhibited. DENV-3 isolates had more variable & weaker inhibition.
Given the range of genotypes, this is a strong foundation to examine viral genetic determinants of susceptibility.
Given the range of genotypes, this is a strong foundation to examine viral genetic determinants of susceptibility.
A pleasure to host A. Prof Aaron Irving @batresearch.bsky.social today at the SCMB Infection & Immunity seminar. Wild genetic diversification and antiviral immune adaptations in Chinese horseshoe bats. Great to see large-scale genomics paired with functional in vitro molecular #virology🦇🧬
August 1, 2025 at 4:36 AM
A pleasure to host A. Prof Aaron Irving @batresearch.bsky.social today at the SCMB Infection & Immunity seminar. Wild genetic diversification and antiviral immune adaptations in Chinese horseshoe bats. Great to see large-scale genomics paired with functional in vitro molecular #virology🦇🧬
Great to see Dr @danielrawle.bsky.social back at UQ, now leading the Emerging Viral Diseases Lab. His team is dissecting viral replication and immunopathology to develop antivirals, vaccines, and anti-inflammatories. Exciting work in motion at @qimrb.bsky.social 🦠🧬 #virology
May 28, 2025 at 2:12 AM
Great to see Dr @danielrawle.bsky.social back at UQ, now leading the Emerging Viral Diseases Lab. His team is dissecting viral replication and immunopathology to develop antivirals, vaccines, and anti-inflammatories. Exciting work in motion at @qimrb.bsky.social 🦠🧬 #virology
🦠☀️ 11th European Meeting on Viral Zoonoses ☀️🦠
September 20–23, 2025 · Saint-Raphaël, France
Join for cutting-edge #virology, sunshine, and sea views!
Speakers include Grazia Cusi, Mark Taylor, Martin Beer, Giuseppe Balistreri, Anna Overby & Nolwenn Jouvenet.
More information 🔗 shorturl.at/xmIEm
September 20–23, 2025 · Saint-Raphaël, France
Join for cutting-edge #virology, sunshine, and sea views!
Speakers include Grazia Cusi, Mark Taylor, Martin Beer, Giuseppe Balistreri, Anna Overby & Nolwenn Jouvenet.
More information 🔗 shorturl.at/xmIEm
May 20, 2025 at 6:21 AM
🦠☀️ 11th European Meeting on Viral Zoonoses ☀️🦠
September 20–23, 2025 · Saint-Raphaël, France
Join for cutting-edge #virology, sunshine, and sea views!
Speakers include Grazia Cusi, Mark Taylor, Martin Beer, Giuseppe Balistreri, Anna Overby & Nolwenn Jouvenet.
More information 🔗 shorturl.at/xmIEm
September 20–23, 2025 · Saint-Raphaël, France
Join for cutting-edge #virology, sunshine, and sea views!
Speakers include Grazia Cusi, Mark Taylor, Martin Beer, Giuseppe Balistreri, Anna Overby & Nolwenn Jouvenet.
More information 🔗 shorturl.at/xmIEm
🔬✨ First Keynote presentation at #MiM2025! for @aussocmic.bsky.social
Dr @nataleenewton.bsky.social is presenting work on tick-borne flaviviruses with a chimeric viral platform, revealing high-resolution cryo-EM structures & antigenic insights. 🦠 Great advances in #flavivirus vaccine development.
Dr @nataleenewton.bsky.social is presenting work on tick-borne flaviviruses with a chimeric viral platform, revealing high-resolution cryo-EM structures & antigenic insights. 🦠 Great advances in #flavivirus vaccine development.
February 8, 2025 at 3:46 AM
🔬✨ First Keynote presentation at #MiM2025! for @aussocmic.bsky.social
Dr @nataleenewton.bsky.social is presenting work on tick-borne flaviviruses with a chimeric viral platform, revealing high-resolution cryo-EM structures & antigenic insights. 🦠 Great advances in #flavivirus vaccine development.
Dr @nataleenewton.bsky.social is presenting work on tick-borne flaviviruses with a chimeric viral platform, revealing high-resolution cryo-EM structures & antigenic insights. 🦠 Great advances in #flavivirus vaccine development.
Excited to be at UniSC at the brand new Petrie campus at #MiM2025 for the ASMQ chapter. Kicking off our day is our Chair Johanna Kenyon, Vice Chair Eva Hatje, and engagement officer Martina Jelocnik
@aussocmic.bsky.social
@aussocmic.bsky.social
February 7, 2025 at 11:48 PM
Excited to be at UniSC at the brand new Petrie campus at #MiM2025 for the ASMQ chapter. Kicking off our day is our Chair Johanna Kenyon, Vice Chair Eva Hatje, and engagement officer Martina Jelocnik
@aussocmic.bsky.social
@aussocmic.bsky.social
Here we provide evidence of henipaviruses in North America with the discovery of Camp hill virus in the Northern Short-Tailed Shrew, Alabama. Early release article available from EID
wwwnc.cdc.gov/eid/article/... #virology
wwwnc.cdc.gov/eid/article/... #virology
January 18, 2025 at 11:39 PM
Here we provide evidence of henipaviruses in North America with the discovery of Camp hill virus in the Northern Short-Tailed Shrew, Alabama. Early release article available from EID
wwwnc.cdc.gov/eid/article/... #virology
wwwnc.cdc.gov/eid/article/... #virology
The only Frontiers guest editor invitation I’ve actually earnestly considered.
December 16, 2024 at 12:19 PM
The only Frontiers guest editor invitation I’ve actually earnestly considered.
Live laugh lab. The Khromykh lab at #AVS12 thanks everyone for a phenomenal meeting. See you all in Adelaide in 2026! @ausvirologysoc.bsky.social
December 6, 2024 at 4:13 AM
Live laugh lab. The Khromykh lab at #AVS12 thanks everyone for a phenomenal meeting. See you all in Adelaide in 2026! @ausvirologysoc.bsky.social
Kicking off the Virus-Host interaction session with Jessica Neil at #AVS12 talking about their extensive respiratory tract platform as a model to study coronaviruses.
December 2, 2024 at 11:37 PM
Kicking off the Virus-Host interaction session with Jessica Neil at #AVS12 talking about their extensive respiratory tract platform as a model to study coronaviruses.
Very proud to see the talented Julian Sng from the Short lab presenting his post-acute sequelae (PASC) of COVID-19 at #AVS12 talking about their mouse adapted model and teasing out the phenotype of PASC.
December 2, 2024 at 10:17 PM
Very proud to see the talented Julian Sng from the Short lab presenting his post-acute sequelae (PASC) of COVID-19 at #AVS12 talking about their mouse adapted model and teasing out the phenotype of PASC.
New from the RNA Virology lab: We characterized 2021-2022 vaccine & hybrid immunity cohorts for #SARSCoV2 in QLD AUS and generated an ΔORF3-8 attenuated strain. We validated this virus in neutralization assays with a sera panel and hope for future use in BSL2/PC2.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 13, 2024 at 12:35 AM
New from the RNA Virology lab: We characterized 2021-2022 vaccine & hybrid immunity cohorts for #SARSCoV2 in QLD AUS and generated an ΔORF3-8 attenuated strain. We validated this virus in neutralization assays with a sera panel and hope for future use in BSL2/PC2.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
There is a second clade of tick #flaviviruses, including Ngoye/Mpulungu #flavivirus. We present Xinyang flavivirus from H. flava in China. These unculturable #viruses are likely "tick-only" with high CpG content and a tendency towards virion immaturity.
www.microbiologyresearch.org/content/jour...
www.microbiologyresearch.org/content/jour...
June 2, 2024 at 2:12 AM
There is a second clade of tick #flaviviruses, including Ngoye/Mpulungu #flavivirus. We present Xinyang flavivirus from H. flava in China. These unculturable #viruses are likely "tick-only" with high CpG content and a tendency towards virion immaturity.
www.microbiologyresearch.org/content/jour...
www.microbiologyresearch.org/content/jour...
A paper from this year I wanted to highlight: Luteo-like ssRNA viruses are ubiquitous in mosquitoes, and I assumed were likely insect-only. Wu et al., show Hubei mosquito virus 2 grows productively in mammalian (BHK/Vero) cells. A result worth validating. #virology journals.asm.org/doi/10.1128/...
December 23, 2023 at 2:57 AM
A paper from this year I wanted to highlight: Luteo-like ssRNA viruses are ubiquitous in mosquitoes, and I assumed were likely insect-only. Wu et al., show Hubei mosquito virus 2 grows productively in mammalian (BHK/Vero) cells. A result worth validating. #virology journals.asm.org/doi/10.1128/...
A lack of reliable structural protein predictions has hindered benchmarking structure-based phylogenetic inferences compared to sequence-only models. Here Moi et al., describe FoldTree showing that structure-based trees can outperform sequence-based trees (sometimes).
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
September 25, 2023 at 4:56 PM
A lack of reliable structural protein predictions has hindered benchmarking structure-based phylogenetic inferences compared to sequence-only models. Here Moi et al., describe FoldTree showing that structure-based trees can outperform sequence-based trees (sometimes).
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Something for everyone in this new #virome study looking at three small mammal orders from @eddieholmes.bsky.social and Yong-Zhen Zhang published in Cell. Of note are some exciting henipaviruses that bridge Langya-like and Hendra-like viruses. #virology www.sciencedirect.com/science/arti...
September 21, 2023 at 1:21 AM
Something for everyone in this new #virome study looking at three small mammal orders from @eddieholmes.bsky.social and Yong-Zhen Zhang published in Cell. Of note are some exciting henipaviruses that bridge Langya-like and Hendra-like viruses. #virology www.sciencedirect.com/science/arti...