Reuven Gordon
@reuven-gordon.bsky.social
Professor. Fellow Optica, SPIE, IEEE. Deputy Editor Optics Express. Nanoaperture Optical Tweezers. Single Molecule Biophysics.
The charge of a single protein gives an additional weak repulsion or attraction in a nanoaperture optical tweezer that can be used to measure the charge on single proteins.
iopscience.iop.org/article/10.1...
iopscience.iop.org/article/10.1...
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iopscience.iop.org
November 19, 2025 at 5:35 AM
The charge of a single protein gives an additional weak repulsion or attraction in a nanoaperture optical tweezer that can be used to measure the charge on single proteins.
iopscience.iop.org/article/10.1...
iopscience.iop.org/article/10.1...
Deep learning for accurate classification of extracellular vesicles from cancer and healthy cells. Delighted to have this successful New Frontiers Research Fund project published today: www.nature.com/articles/s44...
Accurate label free classification of cancerous extracellular vesicles using nanoaperture optical tweezers and deep learning - npj Biosensing
npj Biosensing - Accurate label free classification of cancerous extracellular vesicles using nanoaperture optical tweezers and deep learning
www.nature.com
October 6, 2025 at 2:34 PM
Deep learning for accurate classification of extracellular vesicles from cancer and healthy cells. Delighted to have this successful New Frontiers Research Fund project published today: www.nature.com/articles/s44...
Inaugural Gordon Research Conference on Label-Free Single Molecule Sensing
June 18, 2025 at 12:26 PM
Inaugural Gordon Research Conference on Label-Free Single Molecule Sensing
Label free dynamics of single proteins -- demo video. I love seeing the actual experiment demonstrating how straightforward this approach is (albeit Cuifeng and Mohsen's microfluidics is way more advanced than anything we have attempted).
app.jove.com/v/68093/moni...
app.jove.com/v/68093/moni...
Monitoring Conformational Dynamics of Single Unmodified Proteins using Plasmonic Nanotweezers
Current single-molecule techniques to characterize proteins typically require labels, tethers, or the use of non-native solution conditions. Such changes ...
app.jove.com
June 6, 2025 at 3:45 PM
Label free dynamics of single proteins -- demo video. I love seeing the actual experiment demonstrating how straightforward this approach is (albeit Cuifeng and Mohsen's microfluidics is way more advanced than anything we have attempted).
app.jove.com/v/68093/moni...
app.jove.com/v/68093/moni...
Several Optica journals are seeking to fill Editor-in-Chief positions for 2026 for 3 years: opg.optica.org/info/awoc202...
Announcement to the world-wide optics and photonics communityExpand this Topic
opg.optica.org
May 29, 2025 at 9:37 PM
Several Optica journals are seeking to fill Editor-in-Chief positions for 2026 for 3 years: opg.optica.org/info/awoc202...
The energy landscape of a single disordered protein (tau) and the impact of PTMs is resolved. An important step to understanding the function and dysfunction of disordered proteins from their conformational ensemble. Not yet peer reviewed. www.biorxiv.org/content/10.1...
Direct observation of conformational dynamics of intrinsically disordered proteins at the single-molecule level
Intrinsically disordered proteins (IDPs) and proteins with intrinsically disordered regions (IDRs) are integral to many biological processes, including neurotransmitter regulation, microtubule regulat...
www.biorxiv.org
May 28, 2025 at 6:56 PM
The energy landscape of a single disordered protein (tau) and the impact of PTMs is resolved. An important step to understanding the function and dysfunction of disordered proteins from their conformational ensemble. Not yet peer reviewed. www.biorxiv.org/content/10.1...
Looking forward to talking at LMU Center for Nanoscience www.cens.de/calendar/sum... tomorrow. Check it out in person or online!
CeNS: Gordon
www.cens.de
May 15, 2025 at 6:49 AM
Looking forward to talking at LMU Center for Nanoscience www.cens.de/calendar/sum... tomorrow. Check it out in person or online!
Just had an editorially invited manuscript editorially rejected.
April 9, 2025 at 2:57 PM
Just had an editorially invited manuscript editorially rejected.
How do you watch the conformational dynamics of single molecules without using labels? Here is an excellent tutorial: bsky.app/profile/reuv... #singlemolecule #labelfree #biophysics
bsky.app
March 30, 2025 at 1:29 AM
How do you watch the conformational dynamics of single molecules without using labels? Here is an excellent tutorial: bsky.app/profile/reuv... #singlemolecule #labelfree #biophysics
Reposted by Reuven Gordon
The modified announcements say that up to 15% of doctoral, and 20% of postdoctoral, awards can be held by international scholars.
Hey! Are you an American considering a PhD or a postdoc, and the funding / academic situation just went absolutely bonkers?
Canada's federal funding awards just added eligibility for international applicants if at Cdn institutions.
www.nserc-crsng.gc.ca/NewsDetail-D...
Canada's federal funding awards just added eligibility for international applicants if at Cdn institutions.
www.nserc-crsng.gc.ca/NewsDetail-D...
NSERC - Latest News - Launch of the new Harmonized Tri-agency Scholarship and Fellowship programs
As announced in Budget 2024, the scholarship and fellowship programs administered by the three federal research funding agencies – the Canadian Institutes of Health Research (CIHR), the Natural Sciences and Engineering Research Council (NSERC), and the Social Sciences and Humanities Research Council (SSHRC) – have been streamlined into a new harmonized talent program called the Canada Research Training Awards Suite (CRTAS) that will open for applications in summer 2025.
www.nserc-crsng.gc.ca
March 16, 2025 at 7:16 AM
The modified announcements say that up to 15% of doctoral, and 20% of postdoctoral, awards can be held by international scholars.
Label-free Single Molecule Sensing -- the first conference in this Gordon Research Conference series. Outstanding distinguished invited speaker program just announced: www.grc.org/label-free-s...
Submit your applications early!
#singlemolecule #labelfree
Submit your applications early!
#singlemolecule #labelfree
2025 Label-Free Single Molecule Sensing Conference GRC
The 2025 Gordon Research Conference on Label-Free Single Molecule Sensing will be held in Easton, Massachusetts. Apply today to reserve your spot.
www.grc.org
March 10, 2025 at 3:48 PM
Label-free Single Molecule Sensing -- the first conference in this Gordon Research Conference series. Outstanding distinguished invited speaker program just announced: www.grc.org/label-free-s...
Submit your applications early!
#singlemolecule #labelfree
Submit your applications early!
#singlemolecule #labelfree
Stability maximum of protein conformations observed on a single molecule using real-time label-free approach. #biophysics #singlemolecule
#NOTs
pubs.acs.org/doi/10.1021/...
#NOTs
pubs.acs.org/doi/10.1021/...
Conformational Stability at Low Temperatures Using Single Protein Nanoaperture Optical Tweezers
Nanoaperture optical tweezers allow for trapping single proteins and detecting their conformational changes without modifying the protein, i.e., being free from labels or tethers. While past works have used laser heating as a way to vary the local temperature, this does not allow for probing of lower temperature values. Here we investigate the lower temperature dynamics of individual Bovine Serum Albumin (BSA) proteins with the help of a custom Peltier cooling stage. The BSA transitions between the normal (N) and fast (F) states. The normal form of BSA has a maximum occupancy at 21 ± 1 °C, which is interpreted as its maximum stability point for the compact N form with respect to the F form. In this way, it is possible to find the relative thermodynamic parameters of single proteins without requiring any modifications to the intrinsic structure.
pubs.acs.org
February 20, 2025 at 2:41 PM
Stability maximum of protein conformations observed on a single molecule using real-time label-free approach. #biophysics #singlemolecule
#NOTs
pubs.acs.org/doi/10.1021/...
#NOTs
pubs.acs.org/doi/10.1021/...
Reposted by Reuven Gordon
After lunch, we kicked off the afternoon session with Reuven Gordon from the University of Victoria. He delivered an enlightening presentation on 'Nanoaperture Optical Tweezers for Single Unmodified Protein Dynamics
#SMPS4
#SMPS4
January 21, 2025 at 12:40 PM
After lunch, we kicked off the afternoon session with Reuven Gordon from the University of Victoria. He delivered an enlightening presentation on 'Nanoaperture Optical Tweezers for Single Unmodified Protein Dynamics
#SMPS4
#SMPS4
rdcu.be/d6qG4 Single molecule label-free small molecule interactions for drug discovery. SMAPs. Outstanding work by Annie, Maria and co-authors. #singlemolecule #labelfree #drugdiscovery
Direct observation of small molecule activator binding to single PR65 protein
npj Biosensing - Direct observation of small molecule activator binding to single PR65 protein
rdcu.be
January 16, 2025 at 12:29 PM
rdcu.be/d6qG4 Single molecule label-free small molecule interactions for drug discovery. SMAPs. Outstanding work by Annie, Maria and co-authors. #singlemolecule #labelfree #drugdiscovery
rdcu.be/d6qG4 Single molecule label-free small molecule interactions for drug discovery. SMAPs. Outstanding work by Annie, Maria and co-authors. #singlemolecule #labelfree #drugdiscovery
Direct observation of small molecule activator binding to single PR65 protein
npj Biosensing - Direct observation of small molecule activator binding to single PR65 protein
rdcu.be
January 16, 2025 at 12:28 PM
rdcu.be/d6qG4 Single molecule label-free small molecule interactions for drug discovery. SMAPs. Outstanding work by Annie, Maria and co-authors. #singlemolecule #labelfree #drugdiscovery
Great visit Down Under. NFO17 and Qubic.
December 13, 2024 at 3:31 PM
Great visit Down Under. NFO17 and Qubic.
Another great NFO - Brno in 2026. Thanks @sile-nicchormaic.bsky.social for pic!
December 7, 2024 at 10:21 AM
Another great NFO - Brno in 2026. Thanks @sile-nicchormaic.bsky.social for pic!