Resat Cinar
@resatcinar.bsky.social
Scientist, Dad, Pharmacologist, Pharmacist, Researching on endocannabinoids, cannabinoid receptors, fibrotic disorders, and pulmonary fibrosis. Fibrosis researcher. Opinions are on my own view
Reposted by Resat Cinar
1/4 New Paper 🧠🐭 #Neuroscience #Dopamine #FearExtinction
#eNeuro
Altered Dopamine Signaling in Extinction-Deficient Mice www.eneuro.org/content/12/1...
#eNeuro
Altered Dopamine Signaling in Extinction-Deficient Mice www.eneuro.org/content/12/1...
Altered Dopamine Signaling in Extinction-Deficient Mice
A central mechanism of exposure-based cognitive behavioral therapy for anxiety and trauma-related disorders is fear extinction. However, the mechanisms underlying fear extinction are deficient in some...
www.eneuro.org
December 5, 2025 at 12:16 AM
1/4 New Paper 🧠🐭 #Neuroscience #Dopamine #FearExtinction
#eNeuro
Altered Dopamine Signaling in Extinction-Deficient Mice www.eneuro.org/content/12/1...
#eNeuro
Altered Dopamine Signaling in Extinction-Deficient Mice www.eneuro.org/content/12/1...
✨Exciting to see clinical efficacy of peripheral #CB1R antagonism with #monlunabant. It will expand armamentarium for #obesity with an oral 💊therapy and a different mechanism than incretins ( #GLP1 #GIP)💉
⚡️Similar efficacies in all tested oral doses encourage testing lower doses to optimize safety.
⚡️Similar efficacies in all tested oral doses encourage testing lower doses to optimize safety.
The implications of this trial, combined with existing evidence, suggest that #monlunabant has potential as a novel treatment option for people with #obesity and #metabolic #syndrome, if a safe and effective therapeutic window can be established www.thelancet.com/journals/lan...
#MedSky #EndoSky
#MedSky #EndoSky
October 9, 2025 at 1:53 AM
✨Exciting to see clinical efficacy of peripheral #CB1R antagonism with #monlunabant. It will expand armamentarium for #obesity with an oral 💊therapy and a different mechanism than incretins ( #GLP1 #GIP)💉
⚡️Similar efficacies in all tested oral doses encourage testing lower doses to optimize safety.
⚡️Similar efficacies in all tested oral doses encourage testing lower doses to optimize safety.
📣Our work @jci-insight.bsky.social highlights the key role of #cannabinoid receptor 1 in #AlveolarMacrophages in promoting #PulmonaryFibrosis. We propose that pulmonary delivery of #zevaquanabant as an effective and safer therapeutic approach. Details in🧵👇https://insight.jci.org/articles/view/187967
July 3, 2025 at 6:20 PM
📣Our work @jci-insight.bsky.social highlights the key role of #cannabinoid receptor 1 in #AlveolarMacrophages in promoting #PulmonaryFibrosis. We propose that pulmonary delivery of #zevaquanabant as an effective and safer therapeutic approach. Details in🧵👇https://insight.jci.org/articles/view/187967
‼️A post-doc position available in my lab at the NIH ‼️
⚡️Fibrosis Biology
⚡️Biomarker Discovery
⚡️Pharmacology
⚡️Therapeutic discovery
⚡️Translational research
See the position details👇
www.training.nih.gov/jobs/pdf-090...
#postdoc #medsky #Fibrosis
Please RT⚠️
⚡️Fibrosis Biology
⚡️Biomarker Discovery
⚡️Pharmacology
⚡️Therapeutic discovery
⚡️Translational research
See the position details👇
www.training.nih.gov/jobs/pdf-090...
#postdoc #medsky #Fibrosis
Please RT⚠️
www.training.nih.gov
July 1, 2025 at 11:30 PM
‼️A post-doc position available in my lab at the NIH ‼️
⚡️Fibrosis Biology
⚡️Biomarker Discovery
⚡️Pharmacology
⚡️Therapeutic discovery
⚡️Translational research
See the position details👇
www.training.nih.gov/jobs/pdf-090...
#postdoc #medsky #Fibrosis
Please RT⚠️
⚡️Fibrosis Biology
⚡️Biomarker Discovery
⚡️Pharmacology
⚡️Therapeutic discovery
⚡️Translational research
See the position details👇
www.training.nih.gov/jobs/pdf-090...
#postdoc #medsky #Fibrosis
Please RT⚠️
Our research shows endocannabinoid anandamide in blood has biomarker functions in Hermansky-Pudlak syndrome. It not only captures early stage fibrosis progression in lung but also informs on therapeutic efficacy for CB1R antagonism.This may help to design effective anti-fibrotic therapy for #HPSPF
Anandamide Is a Potential Blood Biomarker of Hermansky-Pudlak Syndrome Pulmonary Fibrosis
This study suggests that circulating anandamide levels begin to increase with the fibrotic lung process even at subclinical stages
@resatcinar.bsky.social #medsky
🔗 tinyurl.com/2p9nrru7
This study suggests that circulating anandamide levels begin to increase with the fibrotic lung process even at subclinical stages
@resatcinar.bsky.social #medsky
🔗 tinyurl.com/2p9nrru7
June 9, 2025 at 11:06 PM
Our research shows endocannabinoid anandamide in blood has biomarker functions in Hermansky-Pudlak syndrome. It not only captures early stage fibrosis progression in lung but also informs on therapeutic efficacy for CB1R antagonism.This may help to design effective anti-fibrotic therapy for #HPSPF