Renkawitz Lab
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renkawitzteam.bsky.social
Renkawitz Lab
@renkawitzteam.bsky.social
Our lab unravels the mechanobiology and cellbiology of immune cells, their migration & cytoskeleton, their organelles, and their cell-matrix interplay using #imaging, #screening, and #bioengineering

@bmc-lmu.bsky.social
www.renkawitz-lab.com
If you are interested in #OrganelleDamage #Mechanics #Microtubules #Cytosk.Forces or #Migration

This zoom-in shows the rapid dynamics of the breakage of the #centrosome - a membrane-less organelle
www.science.org/doi/10.1126/...

Imaged by #separation of the #centriole-pair (black dots; red arrows)
May 15, 2025 at 11:31 AM
Excited to share our discovery www.science.org/doi/10.1126/...

that the #centrosome is prone to breakage!

Using #motile cells, we identify centrosome breakage during #pathfinding, caused by #actin #forces, & prevented by #Dyrk3

Kudos to 1st author Madeleine & thanks to all collaborators!

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April 28, 2025 at 11:51 AM
Happy to transition to this platform to discuss science and share our fascination.

The movie below shows a dendritic cell, highlighting the remarkable ability of immune cells to navigate their cell body and to organise their intracellular cargo (nucleus in cyan).

(Kroll et al, EMBO J 2023)
November 12, 2024 at 7:27 AM