Renkawitz Lab
@renkawitzteam.bsky.social
Our lab unravels the mechanobiology and cellbiology of immune cells, their migration & cytoskeleton, their organelles, and their cell-matrix interplay using #imaging, #screening, and #bioengineering
@bmc-lmu.bsky.social
www.renkawitz-lab.com
@bmc-lmu.bsky.social
www.renkawitz-lab.com
If you are interested in #OrganelleDamage #Mechanics #Microtubules #Cytosk.Forces or #Migration
This zoom-in shows the rapid dynamics of the breakage of the #centrosome - a membrane-less organelle
www.science.org/doi/10.1126/...
Imaged by #separation of the #centriole-pair (black dots; red arrows)
This zoom-in shows the rapid dynamics of the breakage of the #centrosome - a membrane-less organelle
www.science.org/doi/10.1126/...
Imaged by #separation of the #centriole-pair (black dots; red arrows)
May 15, 2025 at 11:31 AM
If you are interested in #OrganelleDamage #Mechanics #Microtubules #Cytosk.Forces or #Migration
This zoom-in shows the rapid dynamics of the breakage of the #centrosome - a membrane-less organelle
www.science.org/doi/10.1126/...
Imaged by #separation of the #centriole-pair (black dots; red arrows)
This zoom-in shows the rapid dynamics of the breakage of the #centrosome - a membrane-less organelle
www.science.org/doi/10.1126/...
Imaged by #separation of the #centriole-pair (black dots; red arrows)
Surprisingly, broken centrosome parts form more than one microtubule-organising centre #MTOC within a single cell
These functional MTOCs #compete during path decisions, thereby delaying pathfinding, and thus causing #entanglement of cells with broken centrosomes in the extracellular #matrix
(4/6)
These functional MTOCs #compete during path decisions, thereby delaying pathfinding, and thus causing #entanglement of cells with broken centrosomes in the extracellular #matrix
(4/6)
April 28, 2025 at 9:58 PM
Surprisingly, broken centrosome parts form more than one microtubule-organising centre #MTOC within a single cell
These functional MTOCs #compete during path decisions, thereby delaying pathfinding, and thus causing #entanglement of cells with broken centrosomes in the extracellular #matrix
(4/6)
These functional MTOCs #compete during path decisions, thereby delaying pathfinding, and thus causing #entanglement of cells with broken centrosomes in the extracellular #matrix
(4/6)
We discover the kinase #Dyrk3 and the known centriole linker #cNAP1 as critical components to prevent centrosome breakage during these deformations
& identify #forces from the actin cytoskeleton as causative forces leading to rapid #fracturing of the centriolar pair at the centrosomal core.
(3/6)
& identify #forces from the actin cytoskeleton as causative forces leading to rapid #fracturing of the centriolar pair at the centrosomal core.
(3/6)
April 28, 2025 at 3:57 PM
We discover the kinase #Dyrk3 and the known centriole linker #cNAP1 as critical components to prevent centrosome breakage during these deformations
& identify #forces from the actin cytoskeleton as causative forces leading to rapid #fracturing of the centriolar pair at the centrosomal core.
(3/6)
& identify #forces from the actin cytoskeleton as causative forces leading to rapid #fracturing of the centriolar pair at the centrosomal core.
(3/6)
Using highly #migratory #immune cells like dendritic cells (DCs) and T cells but also fibroblasts as a model for non-immune cells,
we discover that the centrosome experiences shape #deformations while cells explore their migration path with competing #protrusions
(2/6)
we discover that the centrosome experiences shape #deformations while cells explore their migration path with competing #protrusions
(2/6)
April 28, 2025 at 12:35 PM
Using highly #migratory #immune cells like dendritic cells (DCs) and T cells but also fibroblasts as a model for non-immune cells,
we discover that the centrosome experiences shape #deformations while cells explore their migration path with competing #protrusions
(2/6)
we discover that the centrosome experiences shape #deformations while cells explore their migration path with competing #protrusions
(2/6)
Excited to share our discovery www.science.org/doi/10.1126/...
that the #centrosome is prone to breakage!
Using #motile cells, we identify centrosome breakage during #pathfinding, caused by #actin #forces, & prevented by #Dyrk3
Kudos to 1st author Madeleine & thanks to all collaborators!
(1/6)
that the #centrosome is prone to breakage!
Using #motile cells, we identify centrosome breakage during #pathfinding, caused by #actin #forces, & prevented by #Dyrk3
Kudos to 1st author Madeleine & thanks to all collaborators!
(1/6)
April 28, 2025 at 11:51 AM
Excited to share our discovery www.science.org/doi/10.1126/...
that the #centrosome is prone to breakage!
Using #motile cells, we identify centrosome breakage during #pathfinding, caused by #actin #forces, & prevented by #Dyrk3
Kudos to 1st author Madeleine & thanks to all collaborators!
(1/6)
that the #centrosome is prone to breakage!
Using #motile cells, we identify centrosome breakage during #pathfinding, caused by #actin #forces, & prevented by #Dyrk3
Kudos to 1st author Madeleine & thanks to all collaborators!
(1/6)
We just returned from an imaging session, observing migrating immune cells
I am always excited to see the microtubule network architecture, forming a single aster from the centrosome in dendritic cells
(1st image: microtubules in black, pair of centrioles in red; 2nd: microtubules in fire-colour)
I am always excited to see the microtubule network architecture, forming a single aster from the centrosome in dendritic cells
(1st image: microtubules in black, pair of centrioles in red; 2nd: microtubules in fire-colour)
November 14, 2024 at 2:38 PM
We just returned from an imaging session, observing migrating immune cells
I am always excited to see the microtubule network architecture, forming a single aster from the centrosome in dendritic cells
(1st image: microtubules in black, pair of centrioles in red; 2nd: microtubules in fire-colour)
I am always excited to see the microtubule network architecture, forming a single aster from the centrosome in dendritic cells
(1st image: microtubules in black, pair of centrioles in red; 2nd: microtubules in fire-colour)
Happy to transition to this platform to discuss science and share our fascination.
The movie below shows a dendritic cell, highlighting the remarkable ability of immune cells to navigate their cell body and to organise their intracellular cargo (nucleus in cyan).
(Kroll et al, EMBO J 2023)
The movie below shows a dendritic cell, highlighting the remarkable ability of immune cells to navigate their cell body and to organise their intracellular cargo (nucleus in cyan).
(Kroll et al, EMBO J 2023)
November 12, 2024 at 7:27 AM
Happy to transition to this platform to discuss science and share our fascination.
The movie below shows a dendritic cell, highlighting the remarkable ability of immune cells to navigate their cell body and to organise their intracellular cargo (nucleus in cyan).
(Kroll et al, EMBO J 2023)
The movie below shows a dendritic cell, highlighting the remarkable ability of immune cells to navigate their cell body and to organise their intracellular cargo (nucleus in cyan).
(Kroll et al, EMBO J 2023)