@regevlab.bsky.social
5/
🧠 Altogether, we propose a model:
RNA speckle localization = a marker of early spliceosome assembly, helping ensure efficient and accurate splicing.
🔗 [https://doi.org/10.1101/2025.05.28.656493]
This project was led by Li Wen (@UChicago) and Mauricio A. Arias (@NYU_Courant).
🧠 Altogether, we propose a model:
RNA speckle localization = a marker of early spliceosome assembly, helping ensure efficient and accurate splicing.
🔗 [https://doi.org/10.1101/2025.05.28.656493]
This project was led by Li Wen (@UChicago) and Mauricio A. Arias (@NYU_Courant).
May 29, 2025 at 6:53 PM
5/
🧠 Altogether, we propose a model:
RNA speckle localization = a marker of early spliceosome assembly, helping ensure efficient and accurate splicing.
🔗 [https://doi.org/10.1101/2025.05.28.656493]
This project was led by Li Wen (@UChicago) and Mauricio A. Arias (@NYU_Courant).
🧠 Altogether, we propose a model:
RNA speckle localization = a marker of early spliceosome assembly, helping ensure efficient and accurate splicing.
🔗 [https://doi.org/10.1101/2025.05.28.656493]
This project was led by Li Wen (@UChicago) and Mauricio A. Arias (@NYU_Courant).
4/
⏱️ We find that speckle localization correlates with splicing kinetics.
Stronger localization → Faster splicing
⏱️ We find that speckle localization correlates with splicing kinetics.
Stronger localization → Faster splicing
May 29, 2025 at 6:51 PM
4/
⏱️ We find that speckle localization correlates with splicing kinetics.
Stronger localization → Faster splicing
⏱️ We find that speckle localization correlates with splicing kinetics.
Stronger localization → Faster splicing
3/
🧬 Disease-associated single nucleotide variants (SNVs) reduce the localization of isolated exons, hinting at a potential mechanism for splicing-related pathologies.
🧬 Disease-associated single nucleotide variants (SNVs) reduce the localization of isolated exons, hinting at a potential mechanism for splicing-related pathologies.
May 29, 2025 at 6:51 PM
3/
🧬 Disease-associated single nucleotide variants (SNVs) reduce the localization of isolated exons, hinting at a potential mechanism for splicing-related pathologies.
🧬 Disease-associated single nucleotide variants (SNVs) reduce the localization of isolated exons, hinting at a potential mechanism for splicing-related pathologies.
2/
🔍 Nuclear speckles are membraneless organelles involved in RNA processing.
But what determines which RNAs localize to speckles?
We found that pre-mRNA-like sequences—even in unspliceable transcripts—drive localization.
🔍 Nuclear speckles are membraneless organelles involved in RNA processing.
But what determines which RNAs localize to speckles?
We found that pre-mRNA-like sequences—even in unspliceable transcripts—drive localization.
May 29, 2025 at 6:50 PM
2/
🔍 Nuclear speckles are membraneless organelles involved in RNA processing.
But what determines which RNAs localize to speckles?
We found that pre-mRNA-like sequences—even in unspliceable transcripts—drive localization.
🔍 Nuclear speckles are membraneless organelles involved in RNA processing.
But what determines which RNAs localize to speckles?
We found that pre-mRNA-like sequences—even in unspliceable transcripts—drive localization.