4/
⏱️ We find that speckle localization correlates with splicing kinetics.
Stronger localization → Faster splicing

3/
🧬 Disease-associated single nucleotide variants (SNVs) reduce the localization of isolated exons, hinting at a potential mechanism for splicing-related pathologies.

2/
🔍 Nuclear speckles are membraneless organelles involved in RNA processing.
But what determines which RNAs localize to speckles?
We found that pre-mRNA-like sequences—even in unspliceable transcripts—drive localization.