Richard Sainson
@rcasainson.bsky.social
Excited about science, immunology, tumour microenvironment and new therapies.🇫🇷🇬🇧🇪🇺 ❤️🔬
Who needs CART in IAI? Impressive BiSp data. BCMA T-Cell Engager Therapy in Patients with Refractory Autoimmune Disease | New England Journal of Medicine www.nejm.org/doi/10.1056/...
BCMA T-Cell Engager Therapy in Patients with Refractory Autoimmune Disease | NEJM
Teclistamab, a T-cell engager targeting B-cell maturation antigen, showed promise
as a rescue therapy in 10 patients with refractory autoimmune diseases and led to
clinical and serologic improvemen...
www.nejm.org
November 7, 2025 at 2:10 PM
Who needs CART in IAI? Impressive BiSp data. BCMA T-Cell Engager Therapy in Patients with Refractory Autoimmune Disease | New England Journal of Medicine www.nejm.org/doi/10.1056/...
This report makes some fair points, but it’s not all doom and gloom. Still loads of great science happening in the UK. Sure, before Brexit, the UK attracted more international researchers, which boosted the creative mix, but innovation hasn’t stopped.
www.science.org/content/arti...
www.science.org/content/arti...
U.K. science sector is ‘bleeding to death,’ lawmakers say in report
House of Lords committee urges government to stem exodus of science and technology companies
www.science.org
November 6, 2025 at 8:42 AM
This report makes some fair points, but it’s not all doom and gloom. Still loads of great science happening in the UK. Sure, before Brexit, the UK attracted more international researchers, which boosted the creative mix, but innovation hasn’t stopped.
www.science.org/content/arti...
www.science.org/content/arti...
Keep calm and regulate on!
Some of us tried to kill them. Some of us tried to boost them.
Turns out, Tregs do whatever they can to frustrate us.
Congrats to the Nobel winners for reminding us who’s really in charge, the TReg cell!
Some of us tried to kill them. Some of us tried to boost them.
Turns out, Tregs do whatever they can to frustrate us.
Congrats to the Nobel winners for reminding us who’s really in charge, the TReg cell!
October 6, 2025 at 11:38 AM
Keep calm and regulate on!
Some of us tried to kill them. Some of us tried to boost them.
Turns out, Tregs do whatever they can to frustrate us.
Congrats to the Nobel winners for reminding us who’s really in charge, the TReg cell!
Some of us tried to kill them. Some of us tried to boost them.
Turns out, Tregs do whatever they can to frustrate us.
Congrats to the Nobel winners for reminding us who’s really in charge, the TReg cell!
Nice read about the story of Henri Termeer who changed research of rare disease for good. #Biotech #RareDiseases
October 5, 2025 at 12:11 PM
Nice read about the story of Henri Termeer who changed research of rare disease for good. #Biotech #RareDiseases
Clonal hematopoiesis (CH) is the age-related expansion of mutated blood stem cell clones that increases the risk of blood cancer. A recent publication shows that #IL1RAP isn’t just a marker of CH, it appears to drive it.
lnkd.in/eaCzJUwM
#ClonalHematopoiesis #AML #DrugTarget #CancerPrevention
lnkd.in/eaCzJUwM
#ClonalHematopoiesis #AML #DrugTarget #CancerPrevention
lnkd.in
October 3, 2025 at 2:07 PM
Clonal hematopoiesis (CH) is the age-related expansion of mutated blood stem cell clones that increases the risk of blood cancer. A recent publication shows that #IL1RAP isn’t just a marker of CH, it appears to drive it.
lnkd.in/eaCzJUwM
#ClonalHematopoiesis #AML #DrugTarget #CancerPrevention
lnkd.in/eaCzJUwM
#ClonalHematopoiesis #AML #DrugTarget #CancerPrevention
💊 Paracetamol is safe & effective in approved tablet or liquid forms!
✅ Trust health authorities not rumours.
#HealthFacts #EMA
www.ema.europa.eu/en/news/use-...
✅ Trust health authorities not rumours.
#HealthFacts #EMA
www.ema.europa.eu/en/news/use-...
Use of paracetamol during pregnancy unchanged in the EU | European Medicines Agency (EMA)
Paracetamol medicines can be used in pregnancy, in accordance with official recommendations
www.ema.europa.eu
September 25, 2025 at 5:33 AM
💊 Paracetamol is safe & effective in approved tablet or liquid forms!
✅ Trust health authorities not rumours.
#HealthFacts #EMA
www.ema.europa.eu/en/news/use-...
✅ Trust health authorities not rumours.
#HealthFacts #EMA
www.ema.europa.eu/en/news/use-...
Reposted by Richard Sainson
In our Forest of Biologists we fund the restoration and preservation of ancient woodland and dedicate these trees to our peer reviewers.
There are now over 10,000 trees for peer reviews!
Thank you to all our peer reviewers. Find out more:
forest.biologists.com
#PRW2025 @peerreviewweek.bsky.social
There are now over 10,000 trees for peer reviews!
Thank you to all our peer reviewers. Find out more:
forest.biologists.com
#PRW2025 @peerreviewweek.bsky.social
September 19, 2025 at 10:58 AM
In our Forest of Biologists we fund the restoration and preservation of ancient woodland and dedicate these trees to our peer reviewers.
There are now over 10,000 trees for peer reviews!
Thank you to all our peer reviewers. Find out more:
forest.biologists.com
#PRW2025 @peerreviewweek.bsky.social
There are now over 10,000 trees for peer reviews!
Thank you to all our peer reviewers. Find out more:
forest.biologists.com
#PRW2025 @peerreviewweek.bsky.social
Slides on HARMONi Phase III trial on ivonescimab + platinum-doublet chemotherapy in patients with EGFR-mutated advanced NSCLC... The story continues! www.smmttx.com/wp-content/u...
September 15, 2025 at 4:00 PM
Slides on HARMONi Phase III trial on ivonescimab + platinum-doublet chemotherapy in patients with EGFR-mutated advanced NSCLC... The story continues! www.smmttx.com/wp-content/u...
Source: BioSpace
Nice story emerging from new data for B7H3 ADC in SCLC
Nice story emerging from new data for B7H3 ADC in SCLC
September 8, 2025 at 8:17 PM
Source: BioSpace
Nice story emerging from new data for B7H3 ADC in SCLC
Nice story emerging from new data for B7H3 ADC in SCLC
That was a disturbing read!!!
August 14, 2025 at 8:02 AM
That was a disturbing read!!!
That's sounds interesting... www.nature.com/articles/s41...
Multimodal profiling reveals tissue-directed signatures of human immune cells altered with age - Nature Immunology
Wells et al. profile RNA and surface protein expression to describe dominant tissue-specific effects on immune cell composition and function across lineages in the human tissues across age.
www.nature.com
August 13, 2025 at 10:10 AM
That's sounds interesting... www.nature.com/articles/s41...
Reposted by Richard Sainson
Save the date for next year’s KI Symposium on Thursday, June 18, 2026! Our theme will be diet & metabolism in cancer. If you were unable to attend this year's symposium or would like to revisit our program, you can now view the videos on YouTube:
mit-ki.org/44f6cM3
mit-ki.org/44f6cM3
July 8, 2025 at 4:07 PM
Save the date for next year’s KI Symposium on Thursday, June 18, 2026! Our theme will be diet & metabolism in cancer. If you were unable to attend this year's symposium or would like to revisit our program, you can now view the videos on YouTube:
mit-ki.org/44f6cM3
mit-ki.org/44f6cM3
Next-gen #ADCs sound simple: target, deliver, destroy...
Behind the scenes? It’s cutting-edge chemistry and evolving toxicology. With #AI, a new era of bispecifics will be emerging driven by smarter target pairings (Tumor + TME) and optimized payload combos!
jarlencapital.com/journal/the-...
Behind the scenes? It’s cutting-edge chemistry and evolving toxicology. With #AI, a new era of bispecifics will be emerging driven by smarter target pairings (Tumor + TME) and optimized payload combos!
jarlencapital.com/journal/the-...
The Evolving Frontier of Antibody-Drug Conjugates - My Framer Site
We help innovative companies reach their full operational potential through strategic investment and hands-on support. Our goal is to drive growth, improve efficiency, and increase sales for long term...
jarlencapital.com
July 21, 2025 at 9:44 AM
Next-gen #ADCs sound simple: target, deliver, destroy...
Behind the scenes? It’s cutting-edge chemistry and evolving toxicology. With #AI, a new era of bispecifics will be emerging driven by smarter target pairings (Tumor + TME) and optimized payload combos!
jarlencapital.com/journal/the-...
Behind the scenes? It’s cutting-edge chemistry and evolving toxicology. With #AI, a new era of bispecifics will be emerging driven by smarter target pairings (Tumor + TME) and optimized payload combos!
jarlencapital.com/journal/the-...
💥 IO × Angiogenesis is (continuing) having its moment.
📈 Big bets are being made.
Exciting times ahead in #ImmunoOncology #Angiogeneis ftp.mass-west.com/biotech/sino...
📈 Big bets are being made.
Exciting times ahead in #ImmunoOncology #Angiogeneis ftp.mass-west.com/biotech/sino...
Sino Biopharm buys Merck's PD-1xVEGF bispecific partner LaNova for up to $951M
The PD-1xVEGF dealmaking wave that has captivated Western pharma companies is now surging within China. | Sino Biopharm said it will pay up to $951 million to acquire LaNova Medicines, which has ongoi...
ftp.mass-west.com
July 21, 2025 at 8:35 AM
💥 IO × Angiogenesis is (continuing) having its moment.
📈 Big bets are being made.
Exciting times ahead in #ImmunoOncology #Angiogeneis ftp.mass-west.com/biotech/sino...
📈 Big bets are being made.
Exciting times ahead in #ImmunoOncology #Angiogeneis ftp.mass-west.com/biotech/sino...
2025 Koch Institute Annual Symposium: Peter Senter
YouTube video by KochInstituteMIT
m.youtube.com
July 10, 2025 at 1:37 PM
Exercise ‘better than drugs’ to stop cancer returning after treatment…https://www.theguardian.com/society/2025/jun/01/exercise-better-than-drugs-after-cancer-treatment-international-trial-finds?CMP=Share_iOSApp_Other
June 1, 2025 at 3:40 PM
Exercise ‘better than drugs’ to stop cancer returning after treatment…https://www.theguardian.com/society/2025/jun/01/exercise-better-than-drugs-after-cancer-treatment-international-trial-finds?CMP=Share_iOSApp_Other
The UK secures £500M in EU Horizon #Europe grants, marking a major post #Brexit win for #science. A clear sign of the #EU value in driving global research and innovation.
www.theguardian.com/science/2025...
www.theguardian.com/science/2025...
UK wins £500m in science grants from EU Horizon scheme after Brexit lockout — The Guardian
Exclusive: British scientists ‘over the moon’ with re-entry to funding scheme after losing out for three years
stocks.apple.com
May 5, 2025 at 5:42 AM
The UK secures £500M in EU Horizon #Europe grants, marking a major post #Brexit win for #science. A clear sign of the #EU value in driving global research and innovation.
www.theguardian.com/science/2025...
www.theguardian.com/science/2025...
Anti PD-L1 + anti-TIGIT in NSCLC…. Not convincing….?
May 1, 2025 at 4:44 AM
Anti PD-L1 + anti-TIGIT in NSCLC…. Not convincing….?
Perfect podcast for a Christmas digestive walk…🎄🎁
"Les découvertes scientifiques qui ont changé le monde: Pénicilline, la moisissure bienfaitrice"
www.radiofrance.fr/francecultur...
"Les découvertes scientifiques qui ont changé le monde: Pénicilline, la moisissure bienfaitrice"
www.radiofrance.fr/francecultur...
Pénicilline, la moisissure bienfaitrice : épisode 9/10 du podcast Les découvertes scientifiques qui ont changé le monde
AUDIO • Les découvertes scientifiques qui ont changé le monde, épisode 9/10 : Pénicilline, la moisissure bienfaitrice. Une série inédite proposée par France Culture. Écoutez Ils ont changé le monde, e...
www.radiofrance.fr
December 25, 2024 at 1:36 PM
Perfect podcast for a Christmas digestive walk…🎄🎁
"Les découvertes scientifiques qui ont changé le monde: Pénicilline, la moisissure bienfaitrice"
www.radiofrance.fr/francecultur...
"Les découvertes scientifiques qui ont changé le monde: Pénicilline, la moisissure bienfaitrice"
www.radiofrance.fr/francecultur...
From the group that previously unveiled large-scale changes in the phenotype and genetic profile of AML LSCs, they are now demonstrating that #IL1RAP is consistently maintained during disease progression.-> 🎯 #CCTx001 🎯 #ADV101
www.biorxiv.org/content/10.1...
#AML #ADC #CellTherapy
www.biorxiv.org/content/10.1...
#AML #ADC #CellTherapy
Targeting IL-1/IRAK1/4 signaling in Acute Myeloid Leukemia Stem Cells Following Treatment and Relapse
Therapies for acute myeloid leukemia (AML) face formidable challenges due to relapse, often driven by leukemia stem cells (LSCs). Strategies targeting LSCs hold promise for enhancing outcomes, yet pai...
www.biorxiv.org
November 29, 2024 at 5:57 AM
From the group that previously unveiled large-scale changes in the phenotype and genetic profile of AML LSCs, they are now demonstrating that #IL1RAP is consistently maintained during disease progression.-> 🎯 #CCTx001 🎯 #ADV101
www.biorxiv.org/content/10.1...
#AML #ADC #CellTherapy
www.biorxiv.org/content/10.1...
#AML #ADC #CellTherapy
Reposted by Richard Sainson
CD45-antibody-drug conjugate clears tissue resident myeloid cells from their niches enabling therapeutic adoptive cell transfer https://www.biorxiv.org/content/10.1101/2023.09.05.556397v1
CD45-antibody-drug conjugate clears tissue resident myeloid cells from their niches enabling therapeutic adoptive cell transfer https://www.biorxiv.org/content/10.1101/2023.09.05.556397v1
Tissue resident myeloid cells (TRM) in adults have highly variable lifespans and may be derived from
www.biorxiv.org
September 7, 2023 at 4:16 PM
CD45-antibody-drug conjugate clears tissue resident myeloid cells from their niches enabling therapeutic adoptive cell transfer https://www.biorxiv.org/content/10.1101/2023.09.05.556397v1