This is known issue with Orbitraps. We experienced it during my PhD. This is more prominent when you push the quads closer to unit isolation. Thermo performs a software gimmick to compensate for the lose during quad isolation. Good that they discuss it here in detail

They always do this. Why would anyone use 3700 resolution?. Not a useful option IMHO

I thought so. Trapping before ToF pulsing seem to be the way to improve duty cycle in ToF

Is the AIP similar to the one in Astral. Trapping to increase the duty cycle?

I feel every mass spec vendor want to resurrect IMS since the success of TIMS. I am curious about how PAMAF from Mobilion and its use in Proteomics

Atleast from what j saw and heard at HUPO this year there are minute differences between the Nanomics NP’s and SEER NP’s. One has conjugated peptides to its NP’s and the other not. There could be still a patent infringement

ProAlanase and TrypN works good in our hands

We are! … or will be, we just had a hiccup with the xodus. Last year when we ditched spaces due to Musk, we went back to OG clubhouse. This time we (@ucdproteomics.bsky.social @leannewg.bsky.social) had to chat about it again, hence the delay. Expect announcements here and likely a Dec 4 POTRH.