Bobby Bentham
@rbentham.bsky.social
Senior Bioinformatician @ LifeArc
Pinned
Bobby Bentham
@rbentham.bsky.social
· Feb 18
ImmuneLENS characterizes systemic immune dysregulation in aging and cancer - Nature Genetics
Immune lymphocyte estimation from nucleotide sequencing (ImmuneLENS) infers B cell and T cell fractions from whole-genome sequencing data. Applied to the 100,000 Genomes Project datasets, circulating ...
www.nature.com
🚀 Our paper introducing ImmuneLENS, a new tool that measures T and B cell fractions from WGS data. This builds on our previous method, T cell ExTRECT, that used a signal from V(D)J recombination to measure T cells.
Out today in @naturegenet.bsky.social :
doi.org/10.1038/s41588-025-02086-5
🧵👇
Out today in @naturegenet.bsky.social :
doi.org/10.1038/s41588-025-02086-5
🧵👇
Reposted by Bobby Bentham
Using whole genome sequencing to derive circulating T cell fraction, an immune system metric that has prognostic importance for cancer. And B cell fraction for risk of cancer.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
February 18, 2025 at 2:59 PM
Using whole genome sequencing to derive circulating T cell fraction, an immune system metric that has prognostic importance for cancer. And B cell fraction for risk of cancer.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
🚀 Our paper introducing ImmuneLENS, a new tool that measures T and B cell fractions from WGS data. This builds on our previous method, T cell ExTRECT, that used a signal from V(D)J recombination to measure T cells.
Out today in @naturegenet.bsky.social :
doi.org/10.1038/s41588-025-02086-5
🧵👇
Out today in @naturegenet.bsky.social :
doi.org/10.1038/s41588-025-02086-5
🧵👇
ImmuneLENS characterizes systemic immune dysregulation in aging and cancer - Nature Genetics
Immune lymphocyte estimation from nucleotide sequencing (ImmuneLENS) infers B cell and T cell fractions from whole-genome sequencing data. Applied to the 100,000 Genomes Project datasets, circulating ...
www.nature.com
February 18, 2025 at 3:24 PM
🚀 Our paper introducing ImmuneLENS, a new tool that measures T and B cell fractions from WGS data. This builds on our previous method, T cell ExTRECT, that used a signal from V(D)J recombination to measure T cells.
Out today in @naturegenet.bsky.social :
doi.org/10.1038/s41588-025-02086-5
🧵👇
Out today in @naturegenet.bsky.social :
doi.org/10.1038/s41588-025-02086-5
🧵👇