Extremely interesting research and thread!
⚡️Mitochondria make ATP, the energy that powers life. But in neurons, with axons up to a meter long, how do these tiny power plants stay functional in the right places? We went looking. 1/n www.biorxiv.org/content/10.6...
Self-renewal of neuronal mitochondria through asymmetric division
Mitochondrial ATP production is essential for life. Mitochondrial function depends on the spatio-temporal coordination of nuclear and mitochondrial genome expression, yet how this coordination occurs ...
www.biorxiv.org
December 19, 2025 at 12:49 PM
Extremely interesting research and thread!
Reposted by Ramon Trullas
New paper - MAPL strikes again! Interested in mitochondrial signalling, inflammation, lysosome biology, pyroptosis, and Parkinson's disease? Have a look, there's something for everyone! Feeling grateful! @mitocollier.bsky.social Funded by #CIHR, @asapresearch.parkinsonsroadmap.org.
rdcu.be/eKKz1 🇨🇦
rdcu.be/eKKz1 🇨🇦
October 14, 2025 at 11:50 AM
New paper - MAPL strikes again! Interested in mitochondrial signalling, inflammation, lysosome biology, pyroptosis, and Parkinson's disease? Have a look, there's something for everyone! Feeling grateful! @mitocollier.bsky.social Funded by #CIHR, @asapresearch.parkinsonsroadmap.org.
rdcu.be/eKKz1 🇨🇦
rdcu.be/eKKz1 🇨🇦
A lovely stay @bric-ucph.bsky.social featuring exceptional and exciting research, with highly experienced colleagues from whom I learned a great deal.
October 1, 2025 at 3:09 PM
A lovely stay @bric-ucph.bsky.social featuring exceptional and exciting research, with highly experienced colleagues from whom I learned a great deal.
Impressive lesson from @pgonzalezrodriguez.bsky.social @MitoNed.bsky.social at #cursonacionalneurociencia in Carmona about her findings that changed textbooks on metabolic flexibility of dopaminergic neurons in neurodegenerative that underlies Parkinson's disease.
June 10, 2025 at 9:31 AM
Impressive lesson from @pgonzalezrodriguez.bsky.social @MitoNed.bsky.social at #cursonacionalneurociencia in Carmona about her findings that changed textbooks on metabolic flexibility of dopaminergic neurons in neurodegenerative that underlies Parkinson's disease.
Very proud of the presentation given by Dr. Margalida Puigròs and Elia Ivars of our work on mitochondrial DNA in Parkinson's disease funded by @mjfoxfoundation.bsky.social at the Annual ciberned @isciiisalud.bsky.social international meeting in Ciudad Real.
May 30, 2025 at 10:38 AM
Very proud of the presentation given by Dr. Margalida Puigròs and Elia Ivars of our work on mitochondrial DNA in Parkinson's disease funded by @mjfoxfoundation.bsky.social at the Annual ciberned @isciiisalud.bsky.social international meeting in Ciudad Real.
Walking from Tavernoles to Folgueroles through the Guilleries mountains along the paths and poems of Mossen Cinto Verdaguer with CET Terrassa @monterrassa.bsky.social @diarideterrassa.bsky.social @cec-cat.bsky.social
May 4, 2025 at 7:02 PM
Walking from Tavernoles to Folgueroles through the Guilleries mountains along the paths and poems of Mossen Cinto Verdaguer with CET Terrassa @monterrassa.bsky.social @diarideterrassa.bsky.social @cec-cat.bsky.social
Wonderful walk among flowers and green wheat fields in Segarra (Lleida) Florejacs Castle with Centre Excursionista de Terrassa @monterrassa.bsky.social
April 26, 2025 at 7:20 PM
Wonderful walk among flowers and green wheat fields in Segarra (Lleida) Florejacs Castle with Centre Excursionista de Terrassa @monterrassa.bsky.social
Reposted by Ramon Trullas
My father-in-law, Jack Strominger, and I wrote a letter to the @wsj.com editor about the current threats to science due to Trump's funding freeze. Please repost! www.wsj.com/opinion/scie...
Opinion | Science Suffers With Trump’s Funding Freeze
America’s scientific enterprise demands reliable stewardship, not destabilizing political intervention.
www.wsj.com
April 21, 2025 at 6:21 PM
My father-in-law, Jack Strominger, and I wrote a letter to the @wsj.com editor about the current threats to science due to Trump's funding freeze. Please repost! www.wsj.com/opinion/scie...
“The future of biology won’t be siloed—it will be collaborative, interdisciplinary, and deeply creative.” Jennifer Doudna on her profile about Demis Hassabis Alpha Fold in TIME magazine @ageinves.bsky.social
April 19, 2025 at 5:01 PM
“The future of biology won’t be siloed—it will be collaborative, interdisciplinary, and deeply creative.” Jennifer Doudna on her profile about Demis Hassabis Alpha Fold in TIME magazine @ageinves.bsky.social
El optimismo informado procedente de lo único que nos lo puede proporcionar: aferrarnos a la Investigación Científica. Gracias José Antonio. 🙏😍
#WorldParkinsonsDay2025
#WorldParkinsonDay
“En el momento en que entendí que mi párkinson era la única cosa que no iba a cambiar, empecé a mirar las cosas que sí podía cambiar, como la forma en que se financia la investigación”.
M. J. Fox.
theconversation.com/parkinson-en...
#WorldParkinsonDay
“En el momento en que entendí que mi párkinson era la única cosa que no iba a cambiar, empecé a mirar las cosas que sí podía cambiar, como la forma en que se financia la investigación”.
M. J. Fox.
theconversation.com/parkinson-en...
Párkinson: en busca de la ‘llave’ que arregle el motor
El número de enfermos podría triplicarse en los próximos 30 años debido al envejecimiento de la población, con el agravante de que se diagnostica tarde y no existen terapias que puedan prevenir, ralen...
theconversation.com
April 11, 2025 at 9:00 PM
El optimismo informado procedente de lo único que nos lo puede proporcionar: aferrarnos a la Investigación Científica. Gracias José Antonio. 🙏😍
Impressive! A small molecule allosteric activator of Polgamma, which increases mtDNA synthesis and restores pathogenic mutations. Wonderful work! Congratulations 😍🤗
New paper out from the Falkenberg and Gustafsson labs. Thanks to Pretzel for a successful collaboration.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Small molecules restore mutant mitochondrial DNA polymerase activity - Nature
An activator of DNA polymerase γ restores function to disease-causing mutant variants and demonstrates a potential route to treatments for inherited mitochondrial disorders involving POLG mutations.
www.nature.com
April 10, 2025 at 4:29 PM
Impressive! A small molecule allosteric activator of Polgamma, which increases mtDNA synthesis and restores pathogenic mutations. Wonderful work! Congratulations 😍🤗
Congratulations!!! It is certainly a leap forward 👏👏👏
Huge congrats to Pavel Nash on publishing his PhD work! 🎉 We showcase a safer mtDNA gene therapy using a novel mtZFN architecture compatible with a single AAV. Thanks to the entire team! @mrc-mbu.bsky.social
@mbu-postdocs.bsky.social #MitochondrialDisease #mtDNA
www.embopress.org/doi/full/10....
@mbu-postdocs.bsky.social #MitochondrialDisease #mtDNA
www.embopress.org/doi/full/10....
Clinically translatable mitochondrial gene therapy in muscle using tandem mtZFN architecture | EMBO Molecular Medicine
imageimageEfficient mitochondrial gene therapy is achieved with a novel tandem zinc finger nuclease (mtZFN) architecture delivered via adeno-associated viral (AAV) vectors, significantly reducing mutation loads in muscle tissue and rescuing ...
www.embopress.org
April 10, 2025 at 3:48 PM
Congratulations!!! It is certainly a leap forward 👏👏👏
Very proud of this Public Basic-Clinical translational effort and of its growing impact in Health Research: Unique Alzheimer’s research hub reaches a pivotal moment @a-turp.bsky.social @isciiisalud.bsky.social @csic.bsky.social
www.nature.com/articles/d42...
www.nature.com/articles/d42...
Madrid’s unique Alzheimer’s research hub reaches a pivotal moment
By narrowing the gap between clinical care and post-mortem analysis, researchers in Madrid are cultivating a unique bank of data to advance the diagnosis and treatment of dementia.
www.nature.com
March 25, 2025 at 7:59 PM
Very proud of this Public Basic-Clinical translational effort and of its growing impact in Health Research: Unique Alzheimer’s research hub reaches a pivotal moment @a-turp.bsky.social @isciiisalud.bsky.social @csic.bsky.social
www.nature.com/articles/d42...
www.nature.com/articles/d42...
Impressed by the graffiti before arriving at a meeting at the Department of Computer Science and the Faculty of Mathematics in Pisa “Life cannot be reduced to Calculus and Statistics”
March 21, 2025 at 10:44 PM
Impressed by the graffiti before arriving at a meeting at the Department of Computer Science and the Faculty of Mathematics in Pisa “Life cannot be reduced to Calculus and Statistics”
I enjoyed the privilege of attending a meeting by sparksns.org to translate advances in biomedical research on Parkinson's disease to the patients. I anticipate the SParks NS approach will have a huge impact on developing new therapies to prevent neurodegeneration
March 21, 2025 at 10:20 PM
I enjoyed the privilege of attending a meeting by sparksns.org to translate advances in biomedical research on Parkinson's disease to the patients. I anticipate the SParks NS approach will have a huge impact on developing new therapies to prevent neurodegeneration
Muy importante e imprescindible sinergia en investigación biomédica, especialmente ante el nuevo escenario global que se presenta 😍
➡️ La presidenta del #CSIC, @eloisadelpino.bsky.social, ha visitado el @isciiisalud.bsky.social y ha mantenido una reunión con su directora, Marina Pollán
🔬El objetivo del encuentro ha sido consolidar el trabajo conjunto, como Organismos Públicos de Investigación, en ciencia y salud
🔬El objetivo del encuentro ha sido consolidar el trabajo conjunto, como Organismos Públicos de Investigación, en ciencia y salud
March 19, 2025 at 6:23 PM
Muy importante e imprescindible sinergia en investigación biomédica, especialmente ante el nuevo escenario global que se presenta 😍
The punishment of vampires..questioning extreme aging research
www.nytimes.com/2025/01/20/o...
www.nytimes.com/2025/01/20/o...
Opinion | Sorry, No Secret to Life Is Going to Make You Live to 110
Some of the claims behind the longest-lived people are simply improbable.
www.nytimes.com
February 11, 2025 at 8:16 AM
The punishment of vampires..questioning extreme aging research
www.nytimes.com/2025/01/20/o...
www.nytimes.com/2025/01/20/o...
Proud of the exciting and clear talk by Margalida Puigròs presenting her work on mtDNA deletions in prodromal Parkinson’s Disease at @mitoned.bsky.social published in @ebiomedicine.bsky.social thanks to @mjfoxfoundation.bsky.social
January 10, 2025 at 12:44 PM
Proud of the exciting and clear talk by Margalida Puigròs presenting her work on mtDNA deletions in prodromal Parkinson’s Disease at @mitoned.bsky.social published in @ebiomedicine.bsky.social thanks to @mjfoxfoundation.bsky.social
Very proud of Elia Ivars talk on mtDNA in serum as a biomarker o Parkinson’s Disease @mitoned.bsky.social meeting in Sevilla at IBIS thanks to @mjfoxfoundation.bsky.social
January 9, 2025 at 5:44 PM
Very proud of Elia Ivars talk on mtDNA in serum as a biomarker o Parkinson’s Disease @mitoned.bsky.social meeting in Sevilla at IBIS thanks to @mjfoxfoundation.bsky.social
Great presentarion of Aurora Gomez-Duran on hypoxia regulation of mtDNA heteroplasmy. @auroradevea.bsky.social @mitoned.bsky.social meeting
January 9, 2025 at 3:52 PM
Great presentarion of Aurora Gomez-Duran on hypoxia regulation of mtDNA heteroplasmy. @auroradevea.bsky.social @mitoned.bsky.social meeting
stephen Tait reveals that mitochondrial outer membrane integrity regulates a ubiquitin-dependent inflammatory response via RNF123…an impressive tour of force work @MitoNed meeting @mitosrus.bsky.social
January 9, 2025 at 3:46 PM
stephen Tait reveals that mitochondrial outer membrane integrity regulates a ubiquitin-dependent inflammatory response via RNF123…an impressive tour of force work @MitoNed meeting @mitosrus.bsky.social
Reposted by Ramon Trullas
🚨 Exciting news! Our review has been published in Antioxidants 🎉 And it has been elected as the cover story of the latest issue! 🧬 ✨ Don’t miss it: www.mdpi.com/2076-3921/13...
#Mitochondria #Neurodegeneration #Neuroinflammation #OxidativeStress #BrainHealth
#Mitochondria #Neurodegeneration #Neuroinflammation #OxidativeStress #BrainHealth
December 18, 2024 at 8:56 AM
🚨 Exciting news! Our review has been published in Antioxidants 🎉 And it has been elected as the cover story of the latest issue! 🧬 ✨ Don’t miss it: www.mdpi.com/2076-3921/13...
#Mitochondria #Neurodegeneration #Neuroinflammation #OxidativeStress #BrainHealth
#Mitochondria #Neurodegeneration #Neuroinflammation #OxidativeStress #BrainHealth
Very proud of @neurodegenlab.bsky.social attendig the meeting for the 10th Anniversary of CIBER colaborative research network and spreading the word on the role of mtDNA in neurodegeneration & mitophagy
November 28, 2024 at 3:54 PM
Very proud of @neurodegenlab.bsky.social attendig the meeting for the 10th Anniversary of CIBER colaborative research network and spreading the word on the role of mtDNA in neurodegeneration & mitophagy
Reposted by Ramon Trullas
Tissue-specific responses to TFAM and mtDNA copy number manipulation in prematurely ageing mice https://www.biorxiv.org/content/10.1101/2024.11.14.623694v1
Tissue-specific responses to TFAM and mtDNA copy number manipulation in prematurely ageing mice https://www.biorxiv.org/content/10.1101/2024.11.14.623694v1
Somatic mitochondrial DNA (mtDNA) mutations are heavily implicated as important drivers of ageing an
www.biorxiv.org
November 18, 2024 at 2:33 PM
Tissue-specific responses to TFAM and mtDNA copy number manipulation in prematurely ageing mice https://www.biorxiv.org/content/10.1101/2024.11.14.623694v1
November 25, 2024 at 2:48 PM