@radoncdocgee.bsky.social
RadOnc PhysicianScientist, Clin A/Prof Sydney University. Adjunct Research Scientist @CMRI. Usual disclaimers.
Reposted
Review from our lab out today: "Roles for the 3D Genome In the cell cycle, DNA replication, and double strand break repair." Written by @scientistkate.bsky.social, with her co-supervisor @piptaberlay.bsky.social and collaborator Mat Jones. www.frontiersin.org/journals/cel...
March 4, 2025 at 10:05 PM
Review from our lab out today: "Roles for the 3D Genome In the cell cycle, DNA replication, and double strand break repair." Written by @scientistkate.bsky.social, with her co-supervisor @piptaberlay.bsky.social and collaborator Mat Jones. www.frontiersin.org/journals/cel...
Reposted
My research is finally out!
Huge thanks to @thecesarelab.bsky.social, @radoncdocgee.bsky.social, and everyone involved for their invaluable support along the way.
Briefly, we have demonstrated that cell cycle dependent DSB repair pathways guide death outcomes following lethal genomic damage.
Huge thanks to @thecesarelab.bsky.social, @radoncdocgee.bsky.social, and everyone involved for their invaluable support along the way.
Briefly, we have demonstrated that cell cycle dependent DSB repair pathways guide death outcomes following lethal genomic damage.
1/Delighted to announce the newest paper from our lab, “Homologous recombination promotes non-immunogenic mitotic cell death upon DNA damage”, is out today in @naturecellbiology.bsky.social, www.nature.com/articles/s41....
Homologous recombination promotes non-immunogenic mitotic cell death upon DNA damage - Nature Cell Biology
Szmyd et al. show that DNA repair pathways impact whether cells with DNA lesions arrest in mitosis. The formation of homologous recombination-driven double Holliday junctions elicits mitotic cell deat...
www.nature.com
January 13, 2025 at 10:51 AM
My research is finally out!
Huge thanks to @thecesarelab.bsky.social, @radoncdocgee.bsky.social, and everyone involved for their invaluable support along the way.
Briefly, we have demonstrated that cell cycle dependent DSB repair pathways guide death outcomes following lethal genomic damage.
Huge thanks to @thecesarelab.bsky.social, @radoncdocgee.bsky.social, and everyone involved for their invaluable support along the way.
Briefly, we have demonstrated that cell cycle dependent DSB repair pathways guide death outcomes following lethal genomic damage.
6/ ?translational substudies may be available. love to get the thoughts of SBRT experts like @gerryhanna.bsky.social @drewmoghanaki.bsky.social @mguckenberger.bsky.social
January 14, 2025 at 6:56 AM
6/ ?translational substudies may be available. love to get the thoughts of SBRT experts like @gerryhanna.bsky.social @drewmoghanaki.bsky.social @mguckenberger.bsky.social
5/ Hypothesis - all work in vitro so far so lots of provisos - would be that tumours with HR defects would respond better to the combination of SBRT/SABR and immunotherapy.
January 14, 2025 at 6:51 AM
5/ Hypothesis - all work in vitro so far so lots of provisos - would be that tumours with HR defects would respond better to the combination of SBRT/SABR and immunotherapy.
T brilliant team of scientists who did the work led by Radek, incl Sienna Casolin, Lucy French, @annagmanjon.bsky.social, @drmelaniew.bsky.social , Léa Cavalli, Chris Nelson, Scott Page, Andrew Dhawan, Eric Hau, Hilda Pickett, and of course @thecesarelab.bsky.social - great science and friendship
January 14, 2025 at 6:39 AM
T brilliant team of scientists who did the work led by Radek, incl Sienna Casolin, Lucy French, @annagmanjon.bsky.social, @drmelaniew.bsky.social , Léa Cavalli, Chris Nelson, Scott Page, Andrew Dhawan, Eric Hau, Hilda Pickett, and of course @thecesarelab.bsky.social - great science and friendship
4/ We are grateful for much support. This project was not possible without @cmri.bsky.social, funding from NHMRC and ARC and longstanding support of the Western Sydney
Local Health District Radiation Oncology Network.
Local Health District Radiation Oncology Network.
January 14, 2025 at 6:34 AM
4/ We are grateful for much support. This project was not possible without @cmri.bsky.social, funding from NHMRC and ARC and longstanding support of the Western Sydney
Local Health District Radiation Oncology Network.
Local Health District Radiation Oncology Network.
3/ This opens up new therapeutic opportunities to personalise the combination of SABR/SBRT and immunotherapy and run biomarker driven trials
January 14, 2025 at 6:30 AM
3/ This opens up new therapeutic opportunities to personalise the combination of SABR/SBRT and immunotherapy and run biomarker driven trials
2/ @thecesarelab.bsky.social has a wonderful run through of the science. Key take away for the rad onc community: timing and mode of cell death after ablative radiotherapy is dependent DNA repair pathway, with homologous recombination leading to mitotic 'non-immunogenic' cell death
January 14, 2025 at 6:29 AM
2/ @thecesarelab.bsky.social has a wonderful run through of the science. Key take away for the rad onc community: timing and mode of cell death after ablative radiotherapy is dependent DNA repair pathway, with homologous recombination leading to mitotic 'non-immunogenic' cell death
1/ Thrilled that our paper is out today in @naturecellbiology.bsky.social. A collaboration between WSLHD Radiation Oncology Network and @thecesarelab.bsky.social @cmri.bsky.social, led by our very talented post doc Dr Radoslaw Szmyd
1/Delighted to announce the newest paper from our lab, “Homologous recombination promotes non-immunogenic mitotic cell death upon DNA damage”, is out today in @naturecellbiology.bsky.social, www.nature.com/articles/s41....
Homologous recombination promotes non-immunogenic mitotic cell death upon DNA damage - Nature Cell Biology
Szmyd et al. show that DNA repair pathways impact whether cells with DNA lesions arrest in mitosis. The formation of homologous recombination-driven double Holliday junctions elicits mitotic cell deat...
www.nature.com
January 14, 2025 at 6:27 AM
1/ Thrilled that our paper is out today in @naturecellbiology.bsky.social. A collaboration between WSLHD Radiation Oncology Network and @thecesarelab.bsky.social @cmri.bsky.social, led by our very talented post doc Dr Radoslaw Szmyd