Rachael Kretsch
@rachael-kretsch.bsky.social
Biophysics PhD Student with DasLab & ChiuLab.
Pairing RNA structure & cryoEM to better understand both!
King's College, Science & Security '19
Harvey Mudd '18
Pairing RNA structure & cryoEM to better understand both!
King's College, Science & Security '19
Harvey Mudd '18
Reposted by Rachael Kretsch
Registration to the next RNA BENASQUE meeting July 05-17 2026 is open.
benasque.org/2026rna/
Yes, Benasque is my profile pic. This #RNA meeting puts together for 2 weeks researchers in computational methods for structural RNA. 9th edition already! #RNAsky
benasque.org/2026rna/
Yes, Benasque is my profile pic. This #RNA meeting puts together for 2 weeks researchers in computational methods for structural RNA. 9th edition already! #RNAsky
Computational Approaches to RNA Structure and Function
benasque.org
November 1, 2025 at 1:03 AM
Registration to the next RNA BENASQUE meeting July 05-17 2026 is open.
benasque.org/2026rna/
Yes, Benasque is my profile pic. This #RNA meeting puts together for 2 weeks researchers in computational methods for structural RNA. 9th edition already! #RNAsky
benasque.org/2026rna/
Yes, Benasque is my profile pic. This #RNA meeting puts together for 2 weeks researchers in computational methods for structural RNA. 9th edition already! #RNAsky
Indeed this seminar will be given by none other than the amazing George Ghanim @automnenine.bsky.social , come learn about how human retrotranposons work and interact with their target DNA
Hey thats me.
We have restarted our global Nucleic Acid Strcuture webinar series to bring the expiremental and computational communities together to discuss new developments in the field. Join us this Thursday for the next webinar. Sign up to our mailing list here: groups.google.com/g/casp-rna-sig
September 2, 2025 at 6:34 PM
Indeed this seminar will be given by none other than the amazing George Ghanim @automnenine.bsky.social , come learn about how human retrotranposons work and interact with their target DNA
We have restarted our global Nucleic Acid Strcuture webinar series to bring the expiremental and computational communities together to discuss new developments in the field. Join us this Thursday for the next webinar. Sign up to our mailing list here: groups.google.com/g/casp-rna-sig
September 2, 2025 at 5:50 PM
We have restarted our global Nucleic Acid Strcuture webinar series to bring the expiremental and computational communities together to discuss new developments in the field. Join us this Thursday for the next webinar. Sign up to our mailing list here: groups.google.com/g/casp-rna-sig
When I determed OLE's structure, a transmembrane RNP was staring at me. Took a little bravery to propose this in our manuscript, so I am stoked to see the experts elaborate further. Past data does not rule out OLE RNA spanning the membrane, but data is still needed. Excited for future OLE studies!
🤯 Implications for OLE RNA as a natural integral membrane RNA from Ron Breaker's lab rnajournal.cshlp.org/content/earl...
June 4, 2025 at 8:25 PM
When I determed OLE's structure, a transmembrane RNP was staring at me. Took a little bravery to propose this in our manuscript, so I am stoked to see the experts elaborate further. Past data does not rule out OLE RNA spanning the membrane, but data is still needed. Excited for future OLE studies!
Nucleic acid structural biologists expose that many CASP16 predictions, even ones obtaining high scores by CASP metrics, are inaccurate in the most functionally relevant regions! Read more insights on functionally relevant features by the expert structure determiners (doi.org/10.1101/2025...).
Functional relevance of CASP16 nucleic acid predictions as evaluated by structure providers
Accurate biomolecular structure prediction enables the prediction of mutational effects, the speculation of function based on predicted structural homology, the analysis of ligand binding modes, exper...
doi.org
May 20, 2025 at 10:15 PM
Nucleic acid structural biologists expose that many CASP16 predictions, even ones obtaining high scores by CASP metrics, are inaccurate in the most functionally relevant regions! Read more insights on functionally relevant features by the expert structure determiners (doi.org/10.1101/2025...).
What is the status of nucleic acid structure prediction? Our analysis of CASP16 (doi.org/10.1101/2025...) reveals human expertise is still necessary for the most accurate prediction, but accuracy still heavily relies on templates; having seen a similar structure already.
Assessment of nucleic acid structure prediction in CASP16
Consistently accurate 3D nucleic acid structure prediction would facilitate studies of the diverse RNA and DNA molecules underlying life. In CASP16, blind predictions for 42 targets canvassing a full ...
doi.org
May 20, 2025 at 9:01 PM
What is the status of nucleic acid structure prediction? Our analysis of CASP16 (doi.org/10.1101/2025...) reveals human expertise is still necessary for the most accurate prediction, but accuracy still heavily relies on templates; having seen a similar structure already.
With the CASP16 season over (and a defense behind me), I am very excited to say we will be restarting the nucleic acid SIG webinar + discussion series!
We are actively recruited speakers and co-organizers, get in touch!
Read our short piece about the impact of SIG here: doi.org/10.1002/prot...
We are actively recruited speakers and co-organizers, get in touch!
Read our short piece about the impact of SIG here: doi.org/10.1002/prot...
Engaging the Community: CASP Special Interest Groups
The Critical Assessment of Structure Prediction (CASP) brings together a diverse group of scientists, from deep learning experts to NMR specialists, all aimed at developing accurate prediction algori...
doi.org
May 6, 2025 at 1:00 AM
With the CASP16 season over (and a defense behind me), I am very excited to say we will be restarting the nucleic acid SIG webinar + discussion series!
We are actively recruited speakers and co-organizers, get in touch!
Read our short piece about the impact of SIG here: doi.org/10.1002/prot...
We are actively recruited speakers and co-organizers, get in touch!
Read our short piece about the impact of SIG here: doi.org/10.1002/prot...
Reposted by Rachael Kretsch
The next #CryoEM Current Practices Webinar speaker will be Rachael Kretsch from Stanford speaking on "RNA cryo-EM: unveiling the wonders of RNA biology" 2/27/25 at 12PM ET/9AM PT.
Register today: us02web.zoom.us/webinar/regi...
Learn more about the NIH sponsored cryoEM resources: cryoemcenters.org
Register today: us02web.zoom.us/webinar/regi...
Learn more about the NIH sponsored cryoEM resources: cryoemcenters.org
February 22, 2025 at 10:53 PM
The next #CryoEM Current Practices Webinar speaker will be Rachael Kretsch from Stanford speaking on "RNA cryo-EM: unveiling the wonders of RNA biology" 2/27/25 at 12PM ET/9AM PT.
Register today: us02web.zoom.us/webinar/regi...
Learn more about the NIH sponsored cryoEM resources: cryoemcenters.org
Register today: us02web.zoom.us/webinar/regi...
Learn more about the NIH sponsored cryoEM resources: cryoemcenters.org
Curious about how ensembles have shaped our fundamental understanding of enzyme mechanisms? Check out this amazing work led by Siyuan Du, now published! Congrats all!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
February 14, 2025 at 11:50 PM
Curious about how ensembles have shaped our fundamental understanding of enzyme mechanisms? Check out this amazing work led by Siyuan Du, now published! Congrats all!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Check out preprint: www.biorxiv.org/content/10.1...
January 26, 2025 at 1:40 PM
Check out preprint: www.biorxiv.org/content/10.1...
Check out our new study on water networks in high resolution cryo-EM RNA data!
@ Chiu Lab @ Das Lab
@ Chiu Lab @ Das Lab
January 25, 2025 at 8:01 PM
Check out our new study on water networks in high resolution cryo-EM RNA data!
@ Chiu Lab @ Das Lab
@ Chiu Lab @ Das Lab
We discovered 3 RNA families that form homo-oligomeric RNA-only complexes! Studying nature continues to expand my wildest imagination. Read about it: doi.org/10.1101/2024...
Vivian Wu, Svetlana Shabalina, Hyunbin Lee, Grace Nye, Eugene Koonin, Alex Gao, Rhiju Das, Wah Chiu
Vivian Wu, Svetlana Shabalina, Hyunbin Lee, Grace Nye, Eugene Koonin, Alex Gao, Rhiju Das, Wah Chiu
December 13, 2024 at 12:42 AM
We discovered 3 RNA families that form homo-oligomeric RNA-only complexes! Studying nature continues to expand my wildest imagination. Read about it: doi.org/10.1101/2024...
Vivian Wu, Svetlana Shabalina, Hyunbin Lee, Grace Nye, Eugene Koonin, Alex Gao, Rhiju Das, Wah Chiu
Vivian Wu, Svetlana Shabalina, Hyunbin Lee, Grace Nye, Eugene Koonin, Alex Gao, Rhiju Das, Wah Chiu