Qiwei Yu
@qiweiyu.bsky.social
PhD candidate & Harold W. Dodds Fellow @Princeton | statistical mechanics & theoretical biophysics | previously @IBMResearch @Peking University @Rice University
https://qiweiyuu.github.io/
https://qiweiyuu.github.io/
This session is co-organized with @davidhathcock.bsky.social. The session will also feature invited talks from Victor Sourjik (Max Planck Institute) and Pieter Rein ten Wolde (AMOLF). Look forward to seeing you there!
September 23, 2025 at 3:20 PM
This session is co-organized with @davidhathcock.bsky.social. The session will also feature invited talks from Victor Sourjik (Max Planck Institute) and Pieter Rein ten Wolde (AMOLF). Look forward to seeing you there!
Check out our paper in eLife to see details of the model and more amazing experiments by Alex!
elifesciences.org/articles/104...
elifesciences.org/articles/104...
Nonequilibrium polysome dynamics promote chromosome segregation and its coupling to cell growth in Escherichia coli
Polysome formation within the nucleoid and repulsion between these major cytoplasmic components provide a self-organizing mechanism for chromosome segregation and modulation of its timing across growt...
elifesciences.org
July 7, 2025 at 2:03 PM
Check out our paper in eLife to see details of the model and more amazing experiments by Alex!
elifesciences.org/articles/104...
elifesciences.org/articles/104...
The paper provides comprehensive evidence in support of this mechanism, but here is one of my favs: as a consequence, ectopic polysome accumulations, caused by redirecting gene expression away from the chromosome and toward plasmids, are sufficient to drive aberrant nucleoid dynamics
July 7, 2025 at 2:03 PM
The paper provides comprehensive evidence in support of this mechanism, but here is one of my favs: as a consequence, ectopic polysome accumulations, caused by redirecting gene expression away from the chromosome and toward plasmids, are sufficient to drive aberrant nucleoid dynamics
Not only does our model capture the dynamics of polysome and nucleoid during segregation (kymograph below), but it also explains a linear relation between segregation time and growth rate, with a single (!) fitting parameter (figure below).
July 7, 2025 at 2:03 PM
Not only does our model capture the dynamics of polysome and nucleoid during segregation (kymograph below), but it also explains a linear relation between segregation time and growth rate, with a single (!) fitting parameter (figure below).
With a minimal theoretical model, we show that the segregation dynamics can be explained by considering two ingredients: steric repulsion between polysome and nucleoid, and nonequilibrium production and degradation dynamics of polysomes.
July 7, 2025 at 2:03 PM
With a minimal theoretical model, we show that the segregation dynamics can be explained by considering two ingredients: steric repulsion between polysome and nucleoid, and nonequilibrium production and degradation dynamics of polysomes.
In this paper, we studied how patterns emerge from a combination of the phase separation of lipids and the elastic deformation of the membrane. In a ternary membrane system, we determined how pattern size and morphology depend on lipid composition, surface tension, etc, in agreement with experiments
May 9, 2025 at 12:32 AM
In this paper, we studied how patterns emerge from a combination of the phase separation of lipids and the elastic deformation of the membrane. In a ternary membrane system, we determined how pattern size and morphology depend on lipid composition, surface tension, etc, in agreement with experiments