Quantitative Biosciences Institute, UCSF
@qbi-ucsf.bsky.social
Transforming our understanding of biology and disease through collaborative, quantitative research.
APOE4, the strongest genetic risk for Alzheimer’s, disrupts the recycling centers of nerve cells, laying the foundation for toxic protein accumulation. A new study led by Einar Krogsaeter & Danielle Swaney sheds light on early cellular stress in AD.
Read more: www.tandfonline.com/doi/full/10....
Read more: www.tandfonline.com/doi/full/10....
Lysosomal proteomics reveals mechanisms of neuronal APOE4-associated lysosomal dysfunction
APOE4 is the primary risk factor for Alzheimer disease (AD). Early AD pathological events first affect the neuronal endolysosomal system, which in turn causes neuronal protein aggregation and cell ...
www.tandfonline.com
November 10, 2025 at 7:36 PM
APOE4, the strongest genetic risk for Alzheimer’s, disrupts the recycling centers of nerve cells, laying the foundation for toxic protein accumulation. A new study led by Einar Krogsaeter & Danielle Swaney sheds light on early cellular stress in AD.
Read more: www.tandfonline.com/doi/full/10....
Read more: www.tandfonline.com/doi/full/10....
What happens when a chromosome breaks & how do cells put it back together? Jim Haber @brandeisuniversity.bsky.social will be at UCSF next week to share how scientists learned to watch DNA repair in real time & what that reveals about how cells maintain genetic stability. qbi.ucsf.edu/seminar-haber
November 7, 2025 at 5:51 PM
What happens when a chromosome breaks & how do cells put it back together? Jim Haber @brandeisuniversity.bsky.social will be at UCSF next week to share how scientists learned to watch DNA repair in real time & what that reveals about how cells maintain genetic stability. qbi.ucsf.edu/seminar-haber
Join us on November 13 for a seminar with Dr. Rafael Couñago of UNC on leveraging AI models to accelerate chemical probe discovery for Target 2035!
Learn more & register for his talk: qbi.ucsf.edu/seminar-coun...
Learn more & register for his talk: qbi.ucsf.edu/seminar-coun...
November 6, 2025 at 7:31 PM
Join us on November 13 for a seminar with Dr. Rafael Couñago of UNC on leveraging AI models to accelerate chemical probe discovery for Target 2035!
Learn more & register for his talk: qbi.ucsf.edu/seminar-coun...
Learn more & register for his talk: qbi.ucsf.edu/seminar-coun...
How does AI meet molecular structure to reveal the roots of health & disease?
Join us for a QBI seminar with Dr. Arun Prasad Pandurangan of University of Cambridge on November 12 at UCSF Mission Bay!
Learn more & register: qbi.ucsf.edu/seminar-pand...
Join us for a QBI seminar with Dr. Arun Prasad Pandurangan of University of Cambridge on November 12 at UCSF Mission Bay!
Learn more & register: qbi.ucsf.edu/seminar-pand...
November 5, 2025 at 9:23 PM
How does AI meet molecular structure to reveal the roots of health & disease?
Join us for a QBI seminar with Dr. Arun Prasad Pandurangan of University of Cambridge on November 12 at UCSF Mission Bay!
Learn more & register: qbi.ucsf.edu/seminar-pand...
Join us for a QBI seminar with Dr. Arun Prasad Pandurangan of University of Cambridge on November 12 at UCSF Mission Bay!
Learn more & register: qbi.ucsf.edu/seminar-pand...
How do cells control what enters and exits the nucleus?
A study maps the nuclear pore complex in unprecedented detail, solving a decades-old mystery and offering insights into cancer, Alzheimer’s, and ALS: www.pnas.org/doi/10.1073/...
A study maps the nuclear pore complex in unprecedented detail, solving a decades-old mystery and offering insights into cancer, Alzheimer’s, and ALS: www.pnas.org/doi/10.1073/...
October 28, 2025 at 1:08 AM
How do cells control what enters and exits the nucleus?
A study maps the nuclear pore complex in unprecedented detail, solving a decades-old mystery and offering insights into cancer, Alzheimer’s, and ALS: www.pnas.org/doi/10.1073/...
A study maps the nuclear pore complex in unprecedented detail, solving a decades-old mystery and offering insights into cancer, Alzheimer’s, and ALS: www.pnas.org/doi/10.1073/...
We look forward to welcoming Dr. @andykilianski.bsky.social, Program Manager at ARPA-H for a seminar hosted by James Fraser.
Learn about how ARPA-H is investing in bold, transformative research to shape the future of health in the United States: qbi.ucsf.edu/seminar-kili...
Learn about how ARPA-H is investing in bold, transformative research to shape the future of health in the United States: qbi.ucsf.edu/seminar-kili...
October 24, 2025 at 5:34 PM
We look forward to welcoming Dr. @andykilianski.bsky.social, Program Manager at ARPA-H for a seminar hosted by James Fraser.
Learn about how ARPA-H is investing in bold, transformative research to shape the future of health in the United States: qbi.ucsf.edu/seminar-kili...
Learn about how ARPA-H is investing in bold, transformative research to shape the future of health in the United States: qbi.ucsf.edu/seminar-kili...
AI is powering new frontiers in drug discovery, but success still depends on good data and biological insight.
This @cenmag.bsky.social piece features our director, Nevan Krogan, among voices exploring the real promise and pitfalls of AI in biomedicine.
cen.acs.org/physical-che...
This @cenmag.bsky.social piece features our director, Nevan Krogan, among voices exploring the real promise and pitfalls of AI in biomedicine.
cen.acs.org/physical-che...
October 20, 2025 at 7:53 PM
AI is powering new frontiers in drug discovery, but success still depends on good data and biological insight.
This @cenmag.bsky.social piece features our director, Nevan Krogan, among voices exploring the real promise and pitfalls of AI in biomedicine.
cen.acs.org/physical-che...
This @cenmag.bsky.social piece features our director, Nevan Krogan, among voices exploring the real promise and pitfalls of AI in biomedicine.
cen.acs.org/physical-che...
Join us for the next Infectious Diseases & Human Health Mini-Symposium by @gladstoneinst.bsky.social and QBI: “Viral Landscapes: How to Comprehensively Monitor Evolutionary Trajectories" on 9/23.
Learn more & register: qbi.ucsf.edu/givi-mini-sy...
Learn more & register: qbi.ucsf.edu/givi-mini-sy...
September 19, 2025 at 6:58 PM
Join us for the next Infectious Diseases & Human Health Mini-Symposium by @gladstoneinst.bsky.social and QBI: “Viral Landscapes: How to Comprehensively Monitor Evolutionary Trajectories" on 9/23.
Learn more & register: qbi.ucsf.edu/givi-mini-sy...
Learn more & register: qbi.ucsf.edu/givi-mini-sy...
New QCRG-AViDD study: SARS-CoV protein Orf9b shape-shifts to block our immune defenses by binding to mitochondria’s Tom70. Lipids & mutations tweak how efficiently it works -revealing new insights into coronavirus immune evasion. Learn more: doi.org/10.7554/eLif...
Coupled equilibria of dimerization and lipid binding modulate SARS Cov 2 Orf9b interactions and interferon response
Lipid binding stabilizes the SARS-CoV-2 Orf9b homodimer, slowing its conversion to the Tom70-binding monomeric form and modulating interferon suppression.
doi.org
September 19, 2025 at 6:00 PM
New QCRG-AViDD study: SARS-CoV protein Orf9b shape-shifts to block our immune defenses by binding to mitochondria’s Tom70. Lipids & mutations tweak how efficiently it works -revealing new insights into coronavirus immune evasion. Learn more: doi.org/10.7554/eLif...
The HARC Center supports scientists through Mentored Scientist and Collaborative Developmental Awards, fostering HIV research and training opportunities.
Check out this year’s awardees and the projects they’re working on! 🔬✨https://bit.ly/HARCawards2025
Check out this year’s awardees and the projects they’re working on! 🔬✨https://bit.ly/HARCawards2025
September 11, 2025 at 8:33 PM
The HARC Center supports scientists through Mentored Scientist and Collaborative Developmental Awards, fostering HIV research and training opportunities.
Check out this year’s awardees and the projects they’re working on! 🔬✨https://bit.ly/HARCawards2025
Check out this year’s awardees and the projects they’re working on! 🔬✨https://bit.ly/HARCawards2025
In this QBI TV Fireside Chat, Amber Smith sits down with Zelda Love to share insights from her team’s new cryo-EM structure of the HIV-1 Rev/RRE/CRM1/Ran complex.
Watch the episode & read the study: qbi.ucsf.edu/Smith-Love-Q...
Watch the episode & read the study: qbi.ucsf.edu/Smith-Love-Q...
September 8, 2025 at 10:28 PM
In this QBI TV Fireside Chat, Amber Smith sits down with Zelda Love to share insights from her team’s new cryo-EM structure of the HIV-1 Rev/RRE/CRM1/Ran complex.
Watch the episode & read the study: qbi.ucsf.edu/Smith-Love-Q...
Watch the episode & read the study: qbi.ucsf.edu/Smith-Love-Q...
Speaker lineup announced & registration now open!
Join us for a chance to connect, celebrate, and support the next generation of researchers at the QBI Internship Symposium on 8/19.
qbi.ucsf.edu/qbi-intern-s...
Join us for a chance to connect, celebrate, and support the next generation of researchers at the QBI Internship Symposium on 8/19.
qbi.ucsf.edu/qbi-intern-s...
August 14, 2025 at 8:38 PM
Speaker lineup announced & registration now open!
Join us for a chance to connect, celebrate, and support the next generation of researchers at the QBI Internship Symposium on 8/19.
qbi.ucsf.edu/qbi-intern-s...
Join us for a chance to connect, celebrate, and support the next generation of researchers at the QBI Internship Symposium on 8/19.
qbi.ucsf.edu/qbi-intern-s...
We look forward to hosting Dr. Ludovic Deriano of Institut Pasteur @pasteur.fr next week at UCSF on August 5!
He’ll share how BRCA1/2-deficient cells adapt to DNA damage and how CRISPR screens reveal new targets for cancer therapy.
Learn more & save your spot: qbi.ucsf.edu/seminar-deri...
He’ll share how BRCA1/2-deficient cells adapt to DNA damage and how CRISPR screens reveal new targets for cancer therapy.
Learn more & save your spot: qbi.ucsf.edu/seminar-deri...
July 31, 2025 at 11:48 PM
We look forward to hosting Dr. Ludovic Deriano of Institut Pasteur @pasteur.fr next week at UCSF on August 5!
He’ll share how BRCA1/2-deficient cells adapt to DNA damage and how CRISPR screens reveal new targets for cancer therapy.
Learn more & save your spot: qbi.ucsf.edu/seminar-deri...
He’ll share how BRCA1/2-deficient cells adapt to DNA damage and how CRISPR screens reveal new targets for cancer therapy.
Learn more & save your spot: qbi.ucsf.edu/seminar-deri...
QBI-UCSF launches the Paul Farmer African Initiative for Research (PFAIR) to strengthen research capacity across Africa by building a foundation for sustainable research through mentorship, funding, and international exchange for African scientists.
Learn more: www.ucsf.edu/news/2025/07...
Learn more: www.ucsf.edu/news/2025/07...
July 31, 2025 at 11:47 PM
QBI-UCSF launches the Paul Farmer African Initiative for Research (PFAIR) to strengthen research capacity across Africa by building a foundation for sustainable research through mentorship, funding, and international exchange for African scientists.
Learn more: www.ucsf.edu/news/2025/07...
Learn more: www.ucsf.edu/news/2025/07...
We look forward to having Dr. Andy Kilianski of ARPA-H at QBI for a seminar!
Join us to learn how ARPA-H is investing in bold, high-impact research to transform the future of health in the U.S.
Learn more & register: qbi.ucsf.edu/seminar-kili...
Join us to learn how ARPA-H is investing in bold, high-impact research to transform the future of health in the U.S.
Learn more & register: qbi.ucsf.edu/seminar-kili...
July 10, 2025 at 5:57 PM
We look forward to having Dr. Andy Kilianski of ARPA-H at QBI for a seminar!
Join us to learn how ARPA-H is investing in bold, high-impact research to transform the future of health in the U.S.
Learn more & register: qbi.ucsf.edu/seminar-kili...
Join us to learn how ARPA-H is investing in bold, high-impact research to transform the future of health in the U.S.
Learn more & register: qbi.ucsf.edu/seminar-kili...
We’ve enjoyed having Hoai Nguyen as a visiting scholar this summer! Join us July 14 as she wraps up her time at QBI and @gladstoneinst.bsky.social with a seminar on her team’s CRISPR-based dengue virus diagnostic assay. qbi.ucsf.edu/seminar-hoai...
#GlobalHealth #CRISPR #Dengue
#GlobalHealth #CRISPR #Dengue
July 7, 2025 at 11:38 PM
We’ve enjoyed having Hoai Nguyen as a visiting scholar this summer! Join us July 14 as she wraps up her time at QBI and @gladstoneinst.bsky.social with a seminar on her team’s CRISPR-based dengue virus diagnostic assay. qbi.ucsf.edu/seminar-hoai...
#GlobalHealth #CRISPR #Dengue
#GlobalHealth #CRISPR #Dengue
Dari Kimanius (@czbiohub.bsky.social) is joining us at UCSF @ucsanfrancisco.bsky.social for next week’s AI in Biology symposium!
He’ll share how ML is advancing in situ Cryo-ET and how foundation models are enabling high-throughput discovery.
See full speaker lineup: qbi.ucsf.edu/ai-symposium...
He’ll share how ML is advancing in situ Cryo-ET and how foundation models are enabling high-throughput discovery.
See full speaker lineup: qbi.ucsf.edu/ai-symposium...
June 13, 2025 at 11:34 PM
Dari Kimanius (@czbiohub.bsky.social) is joining us at UCSF @ucsanfrancisco.bsky.social for next week’s AI in Biology symposium!
He’ll share how ML is advancing in situ Cryo-ET and how foundation models are enabling high-throughput discovery.
See full speaker lineup: qbi.ucsf.edu/ai-symposium...
He’ll share how ML is advancing in situ Cryo-ET and how foundation models are enabling high-throughput discovery.
See full speaker lineup: qbi.ucsf.edu/ai-symposium...
Longtime collaborators Steven Altschuler & Lani Wu will share how AI helps map cell phenotypes for early drug discovery, while stressing the need for biological validation.
Hear them at “AI in Biology” @UCSF, June 17–18. qbi.ucsf.edu/ai-symposium...
#QBI #AIinBiology #UCSF #BiotechInnovation
Hear them at “AI in Biology” @UCSF, June 17–18. qbi.ucsf.edu/ai-symposium...
#QBI #AIinBiology #UCSF #BiotechInnovation
June 12, 2025 at 11:56 PM
Longtime collaborators Steven Altschuler & Lani Wu will share how AI helps map cell phenotypes for early drug discovery, while stressing the need for biological validation.
Hear them at “AI in Biology” @UCSF, June 17–18. qbi.ucsf.edu/ai-symposium...
#QBI #AIinBiology #UCSF #BiotechInnovation
Hear them at “AI in Biology” @UCSF, June 17–18. qbi.ucsf.edu/ai-symposium...
#QBI #AIinBiology #UCSF #BiotechInnovation
Next week at UCSF: Brian Cheung of MIT will share how large language models can grasp the real world, even without seeing or hearing a thing!
Catch him at the QBI/Rezo “AI in Biology” symposium June 17–18.
Few tickets left: qbi.ucsf.edu/ai-symposium...
#QBI #AIinBiology #UCSF #BiotechInnovation
Catch him at the QBI/Rezo “AI in Biology” symposium June 17–18.
Few tickets left: qbi.ucsf.edu/ai-symposium...
#QBI #AIinBiology #UCSF #BiotechInnovation
June 12, 2025 at 12:07 AM
Next week at UCSF: Brian Cheung of MIT will share how large language models can grasp the real world, even without seeing or hearing a thing!
Catch him at the QBI/Rezo “AI in Biology” symposium June 17–18.
Few tickets left: qbi.ucsf.edu/ai-symposium...
#QBI #AIinBiology #UCSF #BiotechInnovation
Catch him at the QBI/Rezo “AI in Biology” symposium June 17–18.
Few tickets left: qbi.ucsf.edu/ai-symposium...
#QBI #AIinBiology #UCSF #BiotechInnovation
Meet Cecilia Clementi, Physics Prof at @freieuniversitaet.bsky.social + speaker at the QBI/Rezo “AI in Biology” symposium next week!
Join us June 17–18 at UCSF @ucsanfrancisco.bsky.social: qbi.ucsf.edu/ai-symposium...
#QBI #Rezo #AIinBiology #UCSF #BiotechInnovation
Join us June 17–18 at UCSF @ucsanfrancisco.bsky.social: qbi.ucsf.edu/ai-symposium...
#QBI #Rezo #AIinBiology #UCSF #BiotechInnovation
June 12, 2025 at 12:05 AM
Meet Cecilia Clementi, Physics Prof at @freieuniversitaet.bsky.social + speaker at the QBI/Rezo “AI in Biology” symposium next week!
Join us June 17–18 at UCSF @ucsanfrancisco.bsky.social: qbi.ucsf.edu/ai-symposium...
#QBI #Rezo #AIinBiology #UCSF #BiotechInnovation
Join us June 17–18 at UCSF @ucsanfrancisco.bsky.social: qbi.ucsf.edu/ai-symposium...
#QBI #Rezo #AIinBiology #UCSF #BiotechInnovation
Meet Anil Palepu, Research Scientist at Google and speaker at our QBI/Rezo Therapeutics “AI in Biology” symposium on June 17-18!
Register to join: qbi.ucsf.edu/ai-symposium...
#SpeakerSpotlight #QBI #AIinBiology #RezoTherapeutics #ScienceSymposium #BiotechInnovation #ai
Register to join: qbi.ucsf.edu/ai-symposium...
#SpeakerSpotlight #QBI #AIinBiology #RezoTherapeutics #ScienceSymposium #BiotechInnovation #ai
June 5, 2025 at 5:42 PM
Meet Anil Palepu, Research Scientist at Google and speaker at our QBI/Rezo Therapeutics “AI in Biology” symposium on June 17-18!
Register to join: qbi.ucsf.edu/ai-symposium...
#SpeakerSpotlight #QBI #AIinBiology #RezoTherapeutics #ScienceSymposium #BiotechInnovation #ai
Register to join: qbi.ucsf.edu/ai-symposium...
#SpeakerSpotlight #QBI #AIinBiology #RezoTherapeutics #ScienceSymposium #BiotechInnovation #ai
Meet Angela Oliveira Pisco, Head of Computational Biology at
inistro @insitro.bsky.social and speaker at our QBI/Rezo “AI in Biology” symposium on June 17-18!
Register to join: qbi.ucsf.edu/ai-symposium...
#SpeakerSpotlight #QBI #AIinBiology #RezoTherapeutics #ScienceSymposium #BiotechInnovation
inistro @insitro.bsky.social and speaker at our QBI/Rezo “AI in Biology” symposium on June 17-18!
Register to join: qbi.ucsf.edu/ai-symposium...
#SpeakerSpotlight #QBI #AIinBiology #RezoTherapeutics #ScienceSymposium #BiotechInnovation
June 4, 2025 at 7:08 PM
Meet Angela Oliveira Pisco, Head of Computational Biology at
inistro @insitro.bsky.social and speaker at our QBI/Rezo “AI in Biology” symposium on June 17-18!
Register to join: qbi.ucsf.edu/ai-symposium...
#SpeakerSpotlight #QBI #AIinBiology #RezoTherapeutics #ScienceSymposium #BiotechInnovation
inistro @insitro.bsky.social and speaker at our QBI/Rezo “AI in Biology” symposium on June 17-18!
Register to join: qbi.ucsf.edu/ai-symposium...
#SpeakerSpotlight #QBI #AIinBiology #RezoTherapeutics #ScienceSymposium #BiotechInnovation
Join us June 17–18 at UCSF for “Separating the Signal from the Noise: AI in Biology” — a 2-day symposium with speakers from Google, Genentech, Insitro, MIT, Freie Universität Berlin, CZI, University of Toronto, Alberta Machine Intelligence Institute, QBI UCSF, and Rezo!
qbi.ucsf.edu/ai-symposium...
qbi.ucsf.edu/ai-symposium...
May 30, 2025 at 9:06 PM
Join us June 17–18 at UCSF for “Separating the Signal from the Noise: AI in Biology” — a 2-day symposium with speakers from Google, Genentech, Insitro, MIT, Freie Universität Berlin, CZI, University of Toronto, Alberta Machine Intelligence Institute, QBI UCSF, and Rezo!
qbi.ucsf.edu/ai-symposium...
qbi.ucsf.edu/ai-symposium...
From AI-driven discoveries to building collaborative ecosystems, QBI Director Nevan Krogan shares his vision for the future of science-and why Berlin is an exceptional partner in that mission.
Read the full Q&A via @einsteinberlin.bsky.social: www.einsteinfoundation.de/en/questionn...
Read the full Q&A via @einsteinberlin.bsky.social: www.einsteinfoundation.de/en/questionn...
May 20, 2025 at 6:25 PM
From AI-driven discoveries to building collaborative ecosystems, QBI Director Nevan Krogan shares his vision for the future of science-and why Berlin is an exceptional partner in that mission.
Read the full Q&A via @einsteinberlin.bsky.social: www.einsteinfoundation.de/en/questionn...
Read the full Q&A via @einsteinberlin.bsky.social: www.einsteinfoundation.de/en/questionn...
QBI & Thermo Fisher are hosting a Lunch & Learn on May 9 at UCSF!
Learn how to set up robust quantitative proteomics experiments using cutting-edge mass spectrometry with insights from Kevin Yang & Rafael Melani.
Lunch included!
Learn more & register: qbi.ucsf.edu/qbi-thermo-f...
Learn how to set up robust quantitative proteomics experiments using cutting-edge mass spectrometry with insights from Kevin Yang & Rafael Melani.
Lunch included!
Learn more & register: qbi.ucsf.edu/qbi-thermo-f...
May 5, 2025 at 8:14 PM
QBI & Thermo Fisher are hosting a Lunch & Learn on May 9 at UCSF!
Learn how to set up robust quantitative proteomics experiments using cutting-edge mass spectrometry with insights from Kevin Yang & Rafael Melani.
Lunch included!
Learn more & register: qbi.ucsf.edu/qbi-thermo-f...
Learn how to set up robust quantitative proteomics experiments using cutting-edge mass spectrometry with insights from Kevin Yang & Rafael Melani.
Lunch included!
Learn more & register: qbi.ucsf.edu/qbi-thermo-f...