Christos Proukakis
@proukakis.bsky.social
decided to defect from the other one. Professor of neurology and neurogenetics. Science and maybe politics. Strictly personal opinions obviously
www.nature.com/articles/s42...
After a long wait, our response to criticism of Gauchian for GBA analysis in Illumina WGS is finally published with @sedlazeck.bsky.social thanks to @asapresearch.parkinsonsroadmap.org
After a long wait, our response to criticism of Gauchian for GBA analysis in Illumina WGS is finally published with @sedlazeck.bsky.social thanks to @asapresearch.parkinsonsroadmap.org
Reply to: Is Gauchian genotyping of GBA1 variants reliable? - Communications Biology
Communications Biology - Reply to: Is Gauchian genotyping of GBA1 variants reliable?
www.nature.com
May 9, 2025 at 9:21 AM
www.nature.com/articles/s42...
After a long wait, our response to criticism of Gauchian for GBA analysis in Illumina WGS is finally published with @sedlazeck.bsky.social thanks to @asapresearch.parkinsonsroadmap.org
After a long wait, our response to criticism of Gauchian for GBA analysis in Illumina WGS is finally published with @sedlazeck.bsky.social thanks to @asapresearch.parkinsonsroadmap.org
Reposted by Christos Proukakis
Fresh from our lab - Analyses of muscle biopsies from persons with Parkinson's disease indicate the existence of a subgroup with impaired mitochodrial function. Another step towards biological stratification of PD: www.nature.com/articles/s43...
Mitochondrial complex I deficiency occurs in skeletal muscle of a subgroup of individuals with Parkinson’s disease - Communications Medicine
Kverneng et al. assess the mitochondrial respiratory chain in skeletal muscle from persons with Parkinson’s disease. Their findings suggest the existence of a subpopulation with complex I deficiency a...
www.nature.com
April 30, 2025 at 8:07 AM
Fresh from our lab - Analyses of muscle biopsies from persons with Parkinson's disease indicate the existence of a subgroup with impaired mitochodrial function. Another step towards biological stratification of PD: www.nature.com/articles/s43...
Reposted by Christos Proukakis
Exciting news! The CRN 2025 Technical Track call for LOIs is OPEN!
This #FundingOpportunity supports novel, sustainable tools to accelerate validation & therapeutic R&D for emerging targets from ASAP discoveries 🧪
Join a global network advancing #ParkinsonsResearch.
Apply now: bit.ly/4bhV96G
This #FundingOpportunity supports novel, sustainable tools to accelerate validation & therapeutic R&D for emerging targets from ASAP discoveries 🧪
Join a global network advancing #ParkinsonsResearch.
Apply now: bit.ly/4bhV96G
March 5, 2025 at 4:00 PM
Exciting news! The CRN 2025 Technical Track call for LOIs is OPEN!
This #FundingOpportunity supports novel, sustainable tools to accelerate validation & therapeutic R&D for emerging targets from ASAP discoveries 🧪
Join a global network advancing #ParkinsonsResearch.
Apply now: bit.ly/4bhV96G
This #FundingOpportunity supports novel, sustainable tools to accelerate validation & therapeutic R&D for emerging targets from ASAP discoveries 🧪
Join a global network advancing #ParkinsonsResearch.
Apply now: bit.ly/4bhV96G
Reposted by Christos Proukakis
In this #publication, CRN Team Biederer identifies potential risks related to working with α-syn PFFs and outlines best practices for the safe conduct of research with α-syn fibrils, including PPE and decontamination procedures.
🔗 Check out the full publication: shorturl.at/q2sFU
🔗 Check out the full publication: shorturl.at/q2sFU
March 7, 2025 at 4:27 PM
In this #publication, CRN Team Biederer identifies potential risks related to working with α-syn PFFs and outlines best practices for the safe conduct of research with α-syn fibrils, including PPE and decontamination procedures.
🔗 Check out the full publication: shorturl.at/q2sFU
🔗 Check out the full publication: shorturl.at/q2sFU
Reposted by Christos Proukakis
🧪 We are now accepting LOIs for our Scientific Track funding opportunity through March 20, 2025 (6PM ET).
Your LOI Checklist:
✅ Core Leadership Structure
✅ ECI Requirement
✅ Interdisciplinary Collaboration
✅ Doctoral Degrees
✅ Independent Faculty
Check eligibility & apply: bit.ly/3DXOBxt
Your LOI Checklist:
✅ Core Leadership Structure
✅ ECI Requirement
✅ Interdisciplinary Collaboration
✅ Doctoral Degrees
✅ Independent Faculty
Check eligibility & apply: bit.ly/3DXOBxt
February 20, 2025 at 4:39 PM
🧪 We are now accepting LOIs for our Scientific Track funding opportunity through March 20, 2025 (6PM ET).
Your LOI Checklist:
✅ Core Leadership Structure
✅ ECI Requirement
✅ Interdisciplinary Collaboration
✅ Doctoral Degrees
✅ Independent Faculty
Check eligibility & apply: bit.ly/3DXOBxt
Your LOI Checklist:
✅ Core Leadership Structure
✅ ECI Requirement
✅ Interdisciplinary Collaboration
✅ Doctoral Degrees
✅ Independent Faculty
Check eligibility & apply: bit.ly/3DXOBxt
Gaza death toll 40% higher than official number, Lancet study finds
January 11, 2025 at 12:25 AM
Gaza death toll 40% higher than official number, Lancet study finds
Israel built an ‘AI factory’ for war. It unleashed it in Gaza.
December 30, 2024 at 11:57 AM
Israel built an ‘AI factory’ for war. It unleashed it in Gaza.
in todays financial times "how to spend it" supplement
December 14, 2024 at 11:06 AM
in todays financial times "how to spend it" supplement
Reposted by Christos Proukakis
What mutations hides in our cells? We utilized Nanopore
for WGS single cell sequencing to find out with @proukakis.bsky.social ! Interesting transposon patterns + repeat recombinations! www.medrxiv.org/content/10.1...
Figs: SC deletion also present in bulk. Detection of SC vs. bulk SV
for WGS single cell sequencing to find out with @proukakis.bsky.social ! Interesting transposon patterns + repeat recombinations! www.medrxiv.org/content/10.1...
Figs: SC deletion also present in bulk. Detection of SC vs. bulk SV
November 19, 2024 at 2:39 PM
What mutations hides in our cells? We utilized Nanopore
for WGS single cell sequencing to find out with @proukakis.bsky.social ! Interesting transposon patterns + repeat recombinations! www.medrxiv.org/content/10.1...
Figs: SC deletion also present in bulk. Detection of SC vs. bulk SV
for WGS single cell sequencing to find out with @proukakis.bsky.social ! Interesting transposon patterns + repeat recombinations! www.medrxiv.org/content/10.1...
Figs: SC deletion also present in bulk. Detection of SC vs. bulk SV
www.medrxiv.org/content/10.1...
posting here too for those that didn't see it in the other place! Long read single cell WGS with @sedlazeck.bsky.social
posting here too for those that didn't see it in the other place! Long read single cell WGS with @sedlazeck.bsky.social
Single cell long read whole genome sequencing reveals somatic transposon activity in human brain
The advent of single cell DNA sequencing revealed astonishing dynamics of genomic variability, but failed at characterizing smaller to mid size variants that on the germline level have a profound impa...
www.medrxiv.org
November 19, 2024 at 8:38 AM
www.medrxiv.org/content/10.1...
posting here too for those that didn't see it in the other place! Long read single cell WGS with @sedlazeck.bsky.social
posting here too for those that didn't see it in the other place! Long read single cell WGS with @sedlazeck.bsky.social
November 18, 2024 at 8:41 AM
Reposted by Christos Proukakis
Our lab's first preprint! We identified pathways underlying lipid homeostasis and phase separation of alpha-synuclein that dysfunction and carry an increased burden of rare risk variants in Parkinson's disease patients.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Increased burden of rare risk variants across gene expression networks predisposes to sporadic Parkinson’s disease
Alpha-synuclein (αSyn) is an intrinsically disordered protein that accumulates in the brains of patients with Parkinson’s disease and forms intraneuronal inclusions called Lewy Bodies. While the mecha...
www.biorxiv.org
November 17, 2024 at 9:26 PM
Our lab's first preprint! We identified pathways underlying lipid homeostasis and phase separation of alpha-synuclein that dysfunction and carry an increased burden of rare risk variants in Parkinson's disease patients.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...