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Louise Marston

@proflouisemarston.bsky.social

Professor of Clinical Trials Statistics at Priment Clinical Trials Unit, UCL. England rugby fan, Trailfinders Women. Often out taking photographs.

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Louise Marston

@proflouisemarston.bsky.social

Evidence for health promotion interventions to improve cognitive and physical functioning outcomes in older adults with MCI: A state-of-the-art review www.sciencedirect.com/science/arti... @ucl-caps.bsky.social @ucl-primarycare.bsky.social @drmegs.bsky.social @tasminrookes.bsky.social

Background
Health promotion activities for people with mild cognitive impairment (MCI) may improve their overall health and prevent progression to dementia. We need to understand the best approaches to behaviour change in this population.
Aim
To summarise the types of health promotion interventions and current clinical effectiveness evidence for physical and cognitive functioning outcomes in people with MCI.
Design
State-of-the art review
Method
Medline was searched in April 2025, for systematic reviews synthesising randomised controlled trials testing effectiveness of health promotion interventions in older adults with MCI, published since 2015. Abstracts, titles, and full texts were single screened and, for eligible reviews, the characteristics, intervention type, primary outcome, and evidence for people with MCI, were extracted. Key messages were narratively synthesised across reviews, grouping by type of intervention and outcome measure.
Results
From 1776 titles and abstracts, 57 systematic reviews were eligible. Regular moderate intensity multicomponent physical exercise and memory-focussed cognitive training interventions had the strongest evidence base for improving cognitive functioning. However, combining physical exercise and cognitive training was more beneficial for cognitive domains and physical functioning, in comparison to doing them individually. The evidence for nutrition interventions was mixed. One review of psychological interventions showed improvements for wellbeing.
Conclusion
There is evidence that health promotion interventions can support people with MCI and dementia to improve or maintain their cognitive function, through multicomponent physical activity combined with cognitive training. More evidence is needed for nutritional recommendations, psychological interventions, and social inclusion interventions.

October 7, 2025 at 6:26 PM

Louise Marston

@proflouisemarston.bsky.social

I have just been bought this!

September 12, 2025 at 12:33 PM

Louise Marston

@proflouisemarston.bsky.social

Outcomes of specialist physiotherapy for functional motor disorder: the Physio4FMD RCT NIHR report out today www.journalslibrary.nihr.ac.uk/hta/MKAC9495 @nihr.bsky.social @ucl-primarycare.bsky.social @gnielsenphysio.bsky.social @jonstoneneuro.bsky.social

July 31, 2025 at 5:58 PM

Louise Marston

@proflouisemarston.bsky.social

Methylphenidate versus placebo for fatigue in patients with advanced cancer: the MePFAC randomised controlled trial @nihr.bsky.social report out today. @ucl-primarycare.bsky.social www.journalslibrary.nihr.ac.uk/hta/GJPS6321

Front page of the MePFAC HTA report with abstract.

July 31, 2025 at 4:47 PM

Louise Marston

@proflouisemarston.bsky.social

The association between relapse and the outcome of schizophrenia and recurrent psychotic disorders doi.org/10.1192/bjp.... @joannamoncrieff.bsky.social @soniajohnson1.bsky.social @ucl-primarycare.bsky.social @uclpsychiatry.bsky.social

Abstract from BJPsych for paper: The association between relapse and the outcome of schizophrenia and recurrent psychotic disorders.

April 14, 2025 at 6:37 PM

Louise Marston

@proflouisemarston.bsky.social

Exploring the effect of COVID-19 restrictions on the social functioning scale in a clinical trial of antipsychotic reduction: using multiple imputation to target a hypothetical estimand is out in @jclinepi.bsky.social www.sciencedirect.com/science/arti... 1/n

March 29, 2025 at 11:24 AM

Louise Marston

@proflouisemarston.bsky.social

researchinvolvement.biomedcentral.com/articles/10.... PETAL PPIE involvement in developing the intervention. @proflikahass.bsky.social @ucl-primarycare.bsky.social @uclpsychiatry.bsky.social

March 6, 2025 at 3:31 PM

Louise Marston

@proflouisemarston.bsky.social

Cost-Utility Analysis of Antipsychotic Reduction and Discontinuation in Patients With Long-Term Schizophrenia and Psychosis in English Mental Health Trusts: The RADAR Study

www.valueinhealthjournal.com/article/S109... @ucl-primarycare.bsky.social @uclpsychiatry.bsky.social

February 27, 2025 at 4:34 PM

Louise Marston

@proflouisemarston.bsky.social

Mediation of the association between education and dementia by occupational complexity, income, health behaviours and health outcomes @ucl-primarycare.bsky.social @uclpsychiatry.bsky.social

February 26, 2025 at 7:35 AM

Louise Marston

@proflouisemarston.bsky.social

Which factors predict outcome from specialist physiotherapy for functional motor disorder? Prognostic modelling of the Physio4FMD intervention @ucl-primarycare.bsky.social