Our large design libraries demonstrate that local stability compensation (net free energy of local substructure) correlates with folding accuracy through a Hill equation relationship. 3/4

We show that large, destabilizing loops are often immediately adjacent to more stabilizing stems in natural structures. We also show that designed structures fold more closely to their design when local stability compensation is considered. 2/4

We hope to apply these methods to identify novel structures and to improve our RNA secondary structure meta-database, stay tuned for bpRNA-hub.

I caught a ray of light through the sky bridge between Ag & Life Sciences and Cordley Hall tonight around 7pm. Although the equinox was two days ago, it still works. It was the first day this week that wasn't too cloudy to see anything @oregonstate.edu #beaverhenge #gobeavs!

After some attempts, it occurs to me that a 3D pen is the best method after all. 3D pen printing tends to be string- or stick-like, and is perfect for drawing molecular bonds. I'm experimenting with the technique and would like to further exaggerate the the atoms as round spheres

The design a graduate student in my lab came up with for a 3D printer had to be truncated to be printed, and required quite a lot of scaffolds. 3D printers need bulk, and the space-filling approach hides molecular details.

I'm experimenting with 3D printing #RNA with a #3Dpen! It's a work in progress. I did this a few years back, and getting back into it.

#bioinformatics