#LGBTQ+ #IDsky
https://en.wikipedia.org/wiki/Chloe_Orkin
• 122 participants
•43% PLWH
•no statistical differences in response or viral clearance
• 122 participants
•43% PLWH
•no statistical differences in response or viral clearance
•drug levels & tissue effectiveness of PrEP > in rectal than vaginal tissue (FGT)+ last much longer
•authors found four days on demand more effective than three days
•2-2-2-2 dose effective in 94%
•2-2-2-1 better than 2-2-1
•drug levels & tissue effectiveness of PrEP > in rectal than vaginal tissue (FGT)+ last much longer
•authors found four days on demand more effective than three days
•2-2-2-2 dose effective in 94%
•2-2-2-1 better than 2-2-1
•nucleocapsid resistance may be an important piece of the puzzle of INSTI resistance
•NC mutations alone decrease DTG susceptibility 2-3 fold
•Integrase and NC mutations combined have significantly more phenotypic resistance (4 fold)
•nucleocapsid resistance may be an important piece of the puzzle of INSTI resistance
•NC mutations alone decrease DTG susceptibility 2-3 fold
•Integrase and NC mutations combined have significantly more phenotypic resistance (4 fold)