Prof Chloe Orkin
@profchloeorkin.bsky.social
MBE| Prof of Infection & Inequities QMUL| Director SHARE Collaborative for Health Equity| Dean for Healthcare Transformation | Co-Chair #HIVGlasgow | Ex BHIVA Chair | #HIVsky #Gender #Disabilitysky
#LGBTQ+ #IDsky
https://en.wikipedia.org/wiki/Chloe_Orkin
#LGBTQ+ #IDsky
https://en.wikipedia.org/wiki/Chloe_Orkin
#DEI , women’s rights, LGBTQ+ rights, disability rights, global & domestic public health are under attack and being censored in the US.
Let’s remember the phenomenon of ‘social contagion’ -the concept that thoughts 💭 can be as contagious as viruses 🦠 and keep committing to celebrating #DEI 🏳️🌈🏳️⚧️✊🏿♿️
Let’s remember the phenomenon of ‘social contagion’ -the concept that thoughts 💭 can be as contagious as viruses 🦠 and keep committing to celebrating #DEI 🏳️🌈🏳️⚧️✊🏿♿️
March 20, 2025 at 4:47 PM
#DEI , women’s rights, LGBTQ+ rights, disability rights, global & domestic public health are under attack and being censored in the US.
Let’s remember the phenomenon of ‘social contagion’ -the concept that thoughts 💭 can be as contagious as viruses 🦠 and keep committing to celebrating #DEI 🏳️🌈🏳️⚧️✊🏿♿️
Let’s remember the phenomenon of ‘social contagion’ -the concept that thoughts 💭 can be as contagious as viruses 🦠 and keep committing to celebrating #DEI 🏳️🌈🏳️⚧️✊🏿♿️
Re-suppression post CAB LA PrEP 083 #CROI2025
9/44 had INSTI resistance before ART
6/6 people suppressed on INSTIs (VL less than / equal to 50 c/ML)
15/16 on other ART
5 further participants from other oral regimens switched to INSTIs afterwards and maintained suppression where data available.
9/44 had INSTI resistance before ART
6/6 people suppressed on INSTIs (VL less than / equal to 50 c/ML)
15/16 on other ART
5 further participants from other oral regimens switched to INSTIs afterwards and maintained suppression where data available.
March 12, 2025 at 6:26 PM
Re-suppression post CAB LA PrEP 083 #CROI2025
9/44 had INSTI resistance before ART
6/6 people suppressed on INSTIs (VL less than / equal to 50 c/ML)
15/16 on other ART
5 further participants from other oral regimens switched to INSTIs afterwards and maintained suppression where data available.
9/44 had INSTI resistance before ART
6/6 people suppressed on INSTIs (VL less than / equal to 50 c/ML)
15/16 on other ART
5 further participants from other oral regimens switched to INSTIs afterwards and maintained suppression where data available.
Very strong data from the PILLAR study LA CAB PrEP #CROI2025 60% were cis BiPOC men and were 6% trans men
•201 people
•0 transmissions
•High retention and coverage
•22% had not taken PrEP in past 3/12
•201 people
•0 transmissions
•High retention and coverage
•22% had not taken PrEP in past 3/12
March 12, 2025 at 6:19 PM
Very strong data from the PILLAR study LA CAB PrEP #CROI2025 60% were cis BiPOC men and were 6% trans men
•201 people
•0 transmissions
•High retention and coverage
•22% had not taken PrEP in past 3/12
•201 people
•0 transmissions
•High retention and coverage
•22% had not taken PrEP in past 3/12
Very strong data on LA CAB PrEP from Kaiser Permanente large US real world cohort #CROI2025:
•141 received LA CAB
•25% had never taken PrEP
•75% persistence
•No incident infections
•> 90% of injections given on time
•141 received LA CAB
•25% had never taken PrEP
•75% persistence
•No incident infections
•> 90% of injections given on time
March 12, 2025 at 5:13 PM
Very strong data on LA CAB PrEP from Kaiser Permanente large US real world cohort #CROI2025:
•141 received LA CAB
•25% had never taken PrEP
•75% persistence
•No incident infections
•> 90% of injections given on time
•141 received LA CAB
•25% had never taken PrEP
•75% persistence
•No incident infections
•> 90% of injections given on time
Open label arm of #mpox STOMP trial (people with severe disease/HIV/ pregnant/exfoliative skin) with lab confirmed mpox
• 122 participants
•43% PLWH
•no statistical differences in response or viral clearance
• 122 participants
•43% PLWH
•no statistical differences in response or viral clearance
March 11, 2025 at 6:59 PM
Open label arm of #mpox STOMP trial (people with severe disease/HIV/ pregnant/exfoliative skin) with lab confirmed mpox
• 122 participants
•43% PLWH
•no statistical differences in response or viral clearance
• 122 participants
•43% PLWH
•no statistical differences in response or viral clearance
Optimising on demand TDF/FTC in Cis & trans women:
•drug levels & tissue effectiveness of PrEP > in rectal than vaginal tissue (FGT)+ last much longer
•authors found four days on demand more effective than three days
•2-2-2-2 dose effective in 94%
•2-2-2-1 better than 2-2-1
•drug levels & tissue effectiveness of PrEP > in rectal than vaginal tissue (FGT)+ last much longer
•authors found four days on demand more effective than three days
•2-2-2-2 dose effective in 94%
•2-2-2-1 better than 2-2-1
March 11, 2025 at 6:59 PM
Optimising on demand TDF/FTC in Cis & trans women:
•drug levels & tissue effectiveness of PrEP > in rectal than vaginal tissue (FGT)+ last much longer
•authors found four days on demand more effective than three days
•2-2-2-2 dose effective in 94%
•2-2-2-1 better than 2-2-1
•drug levels & tissue effectiveness of PrEP > in rectal than vaginal tissue (FGT)+ last much longer
•authors found four days on demand more effective than three days
•2-2-2-2 dose effective in 94%
•2-2-2-1 better than 2-2-1
ARV session part 2:
•nucleocapsid resistance may be an important piece of the puzzle of INSTI resistance
•NC mutations alone decrease DTG susceptibility 2-3 fold
•Integrase and NC mutations combined have significantly more phenotypic resistance (4 fold)
•nucleocapsid resistance may be an important piece of the puzzle of INSTI resistance
•NC mutations alone decrease DTG susceptibility 2-3 fold
•Integrase and NC mutations combined have significantly more phenotypic resistance (4 fold)
March 11, 2025 at 6:59 PM
ARV session part 2:
•nucleocapsid resistance may be an important piece of the puzzle of INSTI resistance
•NC mutations alone decrease DTG susceptibility 2-3 fold
•Integrase and NC mutations combined have significantly more phenotypic resistance (4 fold)
•nucleocapsid resistance may be an important piece of the puzzle of INSTI resistance
•NC mutations alone decrease DTG susceptibility 2-3 fold
•Integrase and NC mutations combined have significantly more phenotypic resistance (4 fold)
For those at #CROI2025 there is a ‘Save our Science’ rally this evening at Yerba gardens next to the Moscone centre
Non US people CAN attend but you won’t be able to register
Hope to see you there @iasociety.bsky.social @hivpxresearch.bsky.social @bhiva.bsky.social
Non US people CAN attend but you won’t be able to register
Hope to see you there @iasociety.bsky.social @hivpxresearch.bsky.social @bhiva.bsky.social
March 10, 2025 at 5:03 PM
For those at #CROI2025 there is a ‘Save our Science’ rally this evening at Yerba gardens next to the Moscone centre
Non US people CAN attend but you won’t be able to register
Hope to see you there @iasociety.bsky.social @hivpxresearch.bsky.social @bhiva.bsky.social
Non US people CAN attend but you won’t be able to register
Hope to see you there @iasociety.bsky.social @hivpxresearch.bsky.social @bhiva.bsky.social
National datasets with data or guidelines on gender identity and sexuality have been removed off CDC (centre for disease control ) government websites in recent months. I am here to listen to science on vaccines at a time when high profile meetings on flu strains have been cancelled/ postponed.
March 9, 2025 at 4:50 PM
National datasets with data or guidelines on gender identity and sexuality have been removed off CDC (centre for disease control ) government websites in recent months. I am here to listen to science on vaccines at a time when high profile meetings on flu strains have been cancelled/ postponed.
Unlike federally employed US scientists I have been able to travel here(they are subject to a travel ban). I am able to present data that reports on gender identity (this is banned for government employees as part of the war on ‘woke’ which prevents all research on transgender people and GAHT).
March 9, 2025 at 4:50 PM
Unlike federally employed US scientists I have been able to travel here(they are subject to a travel ban). I am able to present data that reports on gender identity (this is banned for government employees as part of the war on ‘woke’ which prevents all research on transgender people and GAHT).
Post from #CROI2025 San Francisco:
I have been re-posting recently to amplify voices of US colleagues on the war on science and public health that is taking place in the US and the cuts to public funding for PEPFAR HIV programmes supporting treatment and HIV prevention for millions worldwide.
I have been re-posting recently to amplify voices of US colleagues on the war on science and public health that is taking place in the US and the cuts to public funding for PEPFAR HIV programmes supporting treatment and HIV prevention for millions worldwide.
March 9, 2025 at 4:50 PM
Post from #CROI2025 San Francisco:
I have been re-posting recently to amplify voices of US colleagues on the war on science and public health that is taking place in the US and the cuts to public funding for PEPFAR HIV programmes supporting treatment and HIV prevention for millions worldwide.
I have been re-posting recently to amplify voices of US colleagues on the war on science and public health that is taking place in the US and the cuts to public funding for PEPFAR HIV programmes supporting treatment and HIV prevention for millions worldwide.
Kamakura Japan 🇯🇵 - an Autumn/ Fall spectacle to behold 🍁🍂.
November 27, 2024 at 12:34 PM
Kamakura Japan 🇯🇵 - an Autumn/ Fall spectacle to behold 🍁🍂.
Bluesky 🦋 etiquette question:
Is it ok to post photos of trees in the good place?
@brendacrabtreer.bsky.social
@cla-cor.bsky.social
Is it ok to post photos of trees in the good place?
@brendacrabtreer.bsky.social
@cla-cor.bsky.social
November 23, 2024 at 12:19 AM
Bluesky 🦋 etiquette question:
Is it ok to post photos of trees in the good place?
@brendacrabtreer.bsky.social
@cla-cor.bsky.social
Is it ok to post photos of trees in the good place?
@brendacrabtreer.bsky.social
@cla-cor.bsky.social
Key takeaways:
1) Most participants (76%) chose NOT to receive their CAB+RPV injections in the community, but those who did found it highly feasible, acceptable and appropriate.
Community settings we evaluated were home, community support organisation and small clinic
@bhiva.bsky.social
1) Most participants (76%) chose NOT to receive their CAB+RPV injections in the community, but those who did found it highly feasible, acceptable and appropriate.
Community settings we evaluated were home, community support organisation and small clinic
@bhiva.bsky.social
November 14, 2024 at 11:55 AM
Key takeaways:
1) Most participants (76%) chose NOT to receive their CAB+RPV injections in the community, but those who did found it highly feasible, acceptable and appropriate.
Community settings we evaluated were home, community support organisation and small clinic
@bhiva.bsky.social
1) Most participants (76%) chose NOT to receive their CAB+RPV injections in the community, but those who did found it highly feasible, acceptable and appropriate.
Community settings we evaluated were home, community support organisation and small clinic
@bhiva.bsky.social
ILANA is the 1st study exploring delivery of CAB+RPV LAI for PLWH in both clinic and in community settings and to mandate equitable recruitment targets within its protocol.
We enrolled 53% women, 70% racially minoritised ppl, and 40% aged 50+ , showing inclusive recruitment is possible! 💪
We enrolled 53% women, 70% racially minoritised ppl, and 40% aged 50+ , showing inclusive recruitment is possible! 💪
November 14, 2024 at 11:55 AM
ILANA is the 1st study exploring delivery of CAB+RPV LAI for PLWH in both clinic and in community settings and to mandate equitable recruitment targets within its protocol.
We enrolled 53% women, 70% racially minoritised ppl, and 40% aged 50+ , showing inclusive recruitment is possible! 💪
We enrolled 53% women, 70% racially minoritised ppl, and 40% aged 50+ , showing inclusive recruitment is possible! 💪
New EACS guidance on cancer screening at #HIVGlasgow
Screen MSM and TGW>35 and all other men >45
Women >21yrs annually or 3-yearly after three neg PAP smears with CD4 >350 undetectable
Tristan Barber asks how this will be achieved with limited capacity
Screen MSM and TGW>35 and all other men >45
Women >21yrs annually or 3-yearly after three neg PAP smears with CD4 >350 undetectable
Tristan Barber asks how this will be achieved with limited capacity
November 13, 2024 at 9:29 AM
New EACS guidance on cancer screening at #HIVGlasgow
Screen MSM and TGW>35 and all other men >45
Women >21yrs annually or 3-yearly after three neg PAP smears with CD4 >350 undetectable
Tristan Barber asks how this will be achieved with limited capacity
Screen MSM and TGW>35 and all other men >45
Women >21yrs annually or 3-yearly after three neg PAP smears with CD4 >350 undetectable
Tristan Barber asks how this will be achieved with limited capacity
First ever EACS guidelines on chemsex #HIVGlasgow
Ask:
Do you consume drugs before or during planned sex to facilitate, initiate, prolong, sustain and intensify the encounter?
Do you want to see questionnaire score, risk reduction advice and assess level of concern with use
@bhiva.bsky.social
Ask:
Do you consume drugs before or during planned sex to facilitate, initiate, prolong, sustain and intensify the encounter?
Do you want to see questionnaire score, risk reduction advice and assess level of concern with use
@bhiva.bsky.social
November 13, 2024 at 9:17 AM
First ever EACS guidelines on chemsex #HIVGlasgow
Ask:
Do you consume drugs before or during planned sex to facilitate, initiate, prolong, sustain and intensify the encounter?
Do you want to see questionnaire score, risk reduction advice and assess level of concern with use
@bhiva.bsky.social
Ask:
Do you consume drugs before or during planned sex to facilitate, initiate, prolong, sustain and intensify the encounter?
Do you want to see questionnaire score, risk reduction advice and assess level of concern with use
@bhiva.bsky.social
HIV CURE:
Karine Dube asks : do we need to build in an offer of PrEP to partners of participants of ATI ( analytical treatment interruption) studies ?
#HIVGlasgow
@bhiva.bsky.social @tristanjbarber.bsky.social
Karine Dube asks : do we need to build in an offer of PrEP to partners of participants of ATI ( analytical treatment interruption) studies ?
#HIVGlasgow
@bhiva.bsky.social @tristanjbarber.bsky.social
November 12, 2024 at 3:27 PM
HIV CURE:
Karine Dube asks : do we need to build in an offer of PrEP to partners of participants of ATI ( analytical treatment interruption) studies ?
#HIVGlasgow
@bhiva.bsky.social @tristanjbarber.bsky.social
Karine Dube asks : do we need to build in an offer of PrEP to partners of participants of ATI ( analytical treatment interruption) studies ?
#HIVGlasgow
@bhiva.bsky.social @tristanjbarber.bsky.social
Karine Dube :
Ethics of cure- favourable risk/balance ratio.
Risks: social, financial, psychological or physical
Analytical treatment interruptions affect mental health.
Bear in mind: disappointment or stigma associated with viraemia may occur.
Calls for justice-informed ATI
#HIVGlasgow
Ethics of cure- favourable risk/balance ratio.
Risks: social, financial, psychological or physical
Analytical treatment interruptions affect mental health.
Bear in mind: disappointment or stigma associated with viraemia may occur.
Calls for justice-informed ATI
#HIVGlasgow
November 12, 2024 at 3:22 PM
Karine Dube :
Ethics of cure- favourable risk/balance ratio.
Risks: social, financial, psychological or physical
Analytical treatment interruptions affect mental health.
Bear in mind: disappointment or stigma associated with viraemia may occur.
Calls for justice-informed ATI
#HIVGlasgow
Ethics of cure- favourable risk/balance ratio.
Risks: social, financial, psychological or physical
Analytical treatment interruptions affect mental health.
Bear in mind: disappointment or stigma associated with viraemia may occur.
Calls for justice-informed ATI
#HIVGlasgow
#HIVGlasgow
@drlaurajwaters.bsky.social shows systematic review of adverse events on statins.
Helpful ++ for shared-decision making with PLWH.
She mentions potential benefit in vascular dementia and that muscle aches can resolve if statin continued.
BHIVA recommends statins for PLWH > 40 yrs
@drlaurajwaters.bsky.social shows systematic review of adverse events on statins.
Helpful ++ for shared-decision making with PLWH.
She mentions potential benefit in vascular dementia and that muscle aches can resolve if statin continued.
BHIVA recommends statins for PLWH > 40 yrs
November 12, 2024 at 12:29 PM
#HIVGlasgow
@drlaurajwaters.bsky.social shows systematic review of adverse events on statins.
Helpful ++ for shared-decision making with PLWH.
She mentions potential benefit in vascular dementia and that muscle aches can resolve if statin continued.
BHIVA recommends statins for PLWH > 40 yrs
@drlaurajwaters.bsky.social shows systematic review of adverse events on statins.
Helpful ++ for shared-decision making with PLWH.
She mentions potential benefit in vascular dementia and that muscle aches can resolve if statin continued.
BHIVA recommends statins for PLWH > 40 yrs
Happy share to evidence synthesis work from @shareeastlondon.bsky.social
on re-suppression regimens post CAB+RPV from RCT and RWE and on CVF events from RWE #HIVGlasgow
13 cohorts : CVF was <2% in cohorts with> 75 participants
Commonest Post VF regimens RCTs :mostly PI
RWE CAB RPV continuation
on re-suppression regimens post CAB+RPV from RCT and RWE and on CVF events from RWE #HIVGlasgow
13 cohorts : CVF was <2% in cohorts with> 75 participants
Commonest Post VF regimens RCTs :mostly PI
RWE CAB RPV continuation
November 12, 2024 at 11:09 AM
Happy share to evidence synthesis work from @shareeastlondon.bsky.social
on re-suppression regimens post CAB+RPV from RCT and RWE and on CVF events from RWE #HIVGlasgow
13 cohorts : CVF was <2% in cohorts with> 75 participants
Commonest Post VF regimens RCTs :mostly PI
RWE CAB RPV continuation
on re-suppression regimens post CAB+RPV from RCT and RWE and on CVF events from RWE #HIVGlasgow
13 cohorts : CVF was <2% in cohorts with> 75 participants
Commonest Post VF regimens RCTs :mostly PI
RWE CAB RPV continuation
Hi everyone I have just fled X.
I tweet about #HIV #mpox # gender #LGBTQ+ rights #disability rights #inclusion in trials
I tweet about #HIV #mpox # gender #LGBTQ+ rights #disability rights #inclusion in trials
November 11, 2024 at 10:57 AM
Hi everyone I have just fled X.
I tweet about #HIV #mpox # gender #LGBTQ+ rights #disability rights #inclusion in trials
I tweet about #HIV #mpox # gender #LGBTQ+ rights #disability rights #inclusion in trials