Plevka Lab
plevkalab.bsky.social
Plevka Lab
@plevkalab.bsky.social
structural virology ☣️, #cryoEM #cryoET #Lightsheet 🔬 at
CEITEC (Brno) | Tweets by team members.
Hi, can our lab be added to the pack? We study interaction of phages with biofilm 🙂
December 9, 2024 at 12:07 PM
Hi, can our lab be added to the pack? 🙂
December 9, 2024 at 12:06 PM
Hi, can our lab be added to the pack? 🙂
December 9, 2024 at 12:06 PM
Hi, can our lab be added to the pack? 🙂
December 9, 2024 at 12:06 PM
Hello, can you add our lab to the pack? :)
December 9, 2024 at 12:04 PM
Can you, please, add our lab to the list? 🙂
December 9, 2024 at 12:00 PM
Can you, please, add our lab to the list?
December 9, 2024 at 12:00 PM
We would like to be added to the list 🙂
December 9, 2024 at 11:59 AM
📌
December 9, 2024 at 11:54 AM
Thank you, Lars! We’re thrilled to join this vibrant community and connect with amazing labs like yours. Looking forward to engaging discussions and collaborations in structural virology!
December 6, 2024 at 3:42 PM
Stay tuned for more insights into viral entry mechanisms! 🧫
If you liked this #tweetorial, please retweet the first tweet.

bsky.app/profile/plev...

Endosome rupture enables enteroviruses from the family Picornaviridae to infect cells
nature.com/articles/s42...
#CEITECScience
9/9
December 6, 2024 at 2:48 PM
𝗪𝗵𝘆 𝗱𝗼𝗲𝘀 𝘁𝗵𝗶𝘀 𝗺𝗮𝘁𝘁𝗲𝗿?
This study brings us closer to the fundamental understanding of the infection process.
8/9
December 6, 2024 at 2:47 PM
𝗠𝗲𝗺𝗯𝗿𝗮𝗻𝗲 𝘄𝗮𝗿𝗽𝗶𝗻𝗴 𝗮𝗻𝗱 𝗲𝗻𝗱𝗼𝘀𝗼𝗺𝗲 𝗿𝘂𝗽𝘁𝘂𝗿𝗲
Actin filaments observed at membrane protrusions, along with actin polymerisation inhibition results suggest cellular actin can drive endosome rupture.
7/9
December 6, 2024 at 2:47 PM
On the contrary, inhibition of endosome acidification didn’t stop genome-containing particles from exiting the endosomes.
6/9
December 6, 2024 at 2:47 PM
𝗖𝗮𝗻 𝗰𝗲𝗹𝗹𝘂𝗹𝗮𝗿 𝗺𝗲𝗰𝗵𝗮𝗻𝗶𝘀𝗺𝘀 𝗯𝗲 𝗶𝗻𝘃𝗼𝗹𝘃𝗲𝗱? 🦠
Inhibition of the actin polymerisation led to genome release within the endosomes, hindering the virus replication.
5/9
December 6, 2024 at 2:47 PM
𝗛𝗼𝘄 𝗱𝗶𝗱 𝘁𝗵𝗲𝘆 𝗱𝗼 𝗶𝘁?
Using advanced #cryoET at #CEITEC cryoEM facility
to visualise cell entry of rhinovirus 2, echovirus 18, echovirus 30, and enterovirus 71 – right in action! 🔎
4/9
December 6, 2024 at 2:47 PM
𝗞𝗲𝘆 𝗙𝗶𝗻𝗱𝗶𝗻𝗴𝘀
This study reveals that enterovirus-containing #endosomes can deform and rupture, enabling the release of genome-containing particles into the cytoplasm.
3/9
December 6, 2024 at 2:47 PM
#Enteroviruses, members of the Picornaviridae family, cause illnesses ranging from the common cold to encephalitis 😷 However, the infection process was never observed 𝘪𝘯 𝘷𝘪𝘷𝘰 - until now.
2/9
December 6, 2024 at 2:47 PM