Conference season is back! 🔬🧪

We’re excited to return to Nové Hrady for the XXI Discussions in Structural Molecular Biology by @structbiocssb.bsky.social.

Closing the final session, Pavel Plevka dived into the fascinating world of #enterovirus entry—a great way to wrap up the meeting!

❄️ Enjoying the first and, hopefully, not the last snow of this winter ❄️

𝗪𝗵𝘆 𝗱𝗼𝗲𝘀 𝘁𝗵𝗶𝘀 𝗺𝗮𝘁𝘁𝗲𝗿?
This study brings us closer to the fundamental understanding of the infection process.
8/9

𝗠𝗲𝗺𝗯𝗿𝗮𝗻𝗲 𝘄𝗮𝗿𝗽𝗶𝗻𝗴 𝗮𝗻𝗱 𝗲𝗻𝗱𝗼𝘀𝗼𝗺𝗲 𝗿𝘂𝗽𝘁𝘂𝗿𝗲
Actin filaments observed at membrane protrusions, along with actin polymerisation inhibition results suggest cellular actin can drive endosome rupture.
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On the contrary, inhibition of endosome acidification didn’t stop genome-containing particles from exiting the endosomes.
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𝗖𝗮𝗻 𝗰𝗲𝗹𝗹𝘂𝗹𝗮𝗿 𝗺𝗲𝗰𝗵𝗮𝗻𝗶𝘀𝗺𝘀 𝗯𝗲 𝗶𝗻𝘃𝗼𝗹𝘃𝗲𝗱? 🦠
Inhibition of the actin polymerisation led to genome release within the endosomes, hindering the virus replication.
5/9

𝗛𝗼𝘄 𝗱𝗶𝗱 𝘁𝗵𝗲𝘆 𝗱𝗼 𝗶𝘁?
Using advanced #cryoET at #CEITEC cryoEM facility
to visualise cell entry of rhinovirus 2, echovirus 18, echovirus 30, and enterovirus 71 – right in action! 🔎
4/9

𝗞𝗲𝘆 𝗙𝗶𝗻𝗱𝗶𝗻𝗴𝘀
This study reveals that enterovirus-containing #endosomes can deform and rupture, enabling the release of genome-containing particles into the cytoplasm.
3/9

#Enteroviruses, members of the Picornaviridae family, cause illnesses ranging from the common cold to encephalitis 😷 However, the infection process was never observed 𝘪𝘯 𝘷𝘪𝘷𝘰 - until now.
2/9

✨𝗡𝗘𝗪 𝗣𝗔𝗣𝗘𝗥 𝗔𝗟𝗘𝗥𝗧✨
We are happy to announce that the paper by Aygul Ishemgulova and members of our group, describing the novel mechanism of cell invasion by enteroviruses is now published in @commsbio.bsky.social ! 🦠
Let’s break it down!
🧵
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