Mohamed ElTanbouly
@plasmacellguy.bsky.social
Hi Kilian,
Congratulations on this truly important work. Very nicely done
Glad to read the whole story.
Congratulations on this truly important work. Very nicely done
Glad to read the whole story.
October 6, 2025 at 3:27 PM
Hi Kilian,
Congratulations on this truly important work. Very nicely done
Glad to read the whole story.
Congratulations on this truly important work. Very nicely done
Glad to read the whole story.
Well, a Treg is a T cell.
Although another Nobel laureate thinks (thought?) otherwise
pmc.ncbi.nlm.nih.gov/articles/PMC...
Although another Nobel laureate thinks (thought?) otherwise
pmc.ncbi.nlm.nih.gov/articles/PMC...
October 6, 2025 at 3:03 PM
Well, a Treg is a T cell.
Although another Nobel laureate thinks (thought?) otherwise
pmc.ncbi.nlm.nih.gov/articles/PMC...
Although another Nobel laureate thinks (thought?) otherwise
pmc.ncbi.nlm.nih.gov/articles/PMC...
Thank you :)
I've been thinking about and discussing T cell tolerance with several people since the recent Belkaid and Wang papers. Planning to write something (actually wrote but need to post) about this and looking forward to your honest feedback.
I've been thinking about and discussing T cell tolerance with several people since the recent Belkaid and Wang papers. Planning to write something (actually wrote but need to post) about this and looking forward to your honest feedback.
September 2, 2025 at 2:54 PM
Thank you :)
I've been thinking about and discussing T cell tolerance with several people since the recent Belkaid and Wang papers. Planning to write something (actually wrote but need to post) about this and looking forward to your honest feedback.
I've been thinking about and discussing T cell tolerance with several people since the recent Belkaid and Wang papers. Planning to write something (actually wrote but need to post) about this and looking forward to your honest feedback.
Congrats Ruth and colleagues!!!
I enjoyed reading this...Fascinating discovery
Really great work
I enjoyed reading this...Fascinating discovery
Really great work
July 11, 2025 at 2:06 PM
Congrats Ruth and colleagues!!!
I enjoyed reading this...Fascinating discovery
Really great work
I enjoyed reading this...Fascinating discovery
Really great work
Congrats on your terrific effort Payal and co!!! 🎉
Very nice and comprehensive study.
All the best with what comes next.
Very nice and comprehensive study.
All the best with what comes next.
April 30, 2025 at 12:18 AM
Congrats on your terrific effort Payal and co!!! 🎉
Very nice and comprehensive study.
All the best with what comes next.
Very nice and comprehensive study.
All the best with what comes next.
Thanks very much for advising.
April 3, 2025 at 3:34 PM
Thanks very much for advising.
Might I ask you if any of these talks are available on NIHvideocast or youtube? Or accessible online?
April 3, 2025 at 2:29 PM
Might I ask you if any of these talks are available on NIHvideocast or youtube? Or accessible online?
I tried to access but it says that it's only available to Harvard folks
What am I missing? Aside from a Harvard ID card
What am I missing? Aside from a Harvard ID card
January 25, 2025 at 12:28 AM
I tried to access but it says that it's only available to Harvard folks
What am I missing? Aside from a Harvard ID card
What am I missing? Aside from a Harvard ID card
On an irrelevant note, congratulations on this terrific paper
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Tissue-resident memory CD8 T cell diversity is spatiotemporally imprinted - Nature
Profiling of the location and transcriptome of tissue-resident memory CD8 T cell formation at single-transcript resolution finds regionalized signalling as the basis of immune diversity in t...
www.nature.com
January 23, 2025 at 12:43 AM
On an irrelevant note, congratulations on this terrific paper
www.nature.com/articles/s41...
www.nature.com/articles/s41...
This is fascinating!
These are all immune (lymphocyte-relevant) genes!!!!!
These are all immune (lymphocyte-relevant) genes!!!!!
January 23, 2025 at 12:39 AM
This is fascinating!
These are all immune (lymphocyte-relevant) genes!!!!!
These are all immune (lymphocyte-relevant) genes!!!!!
Mitochondria is the powerhouse of the cell
Chloroplast is the cell's farm
ER is the factory and ribosomes are the workers
Plasma membrane are the city walls
Cilia and flagella are the stirring wheels and propellers
Exosomes and endosomes are the email/post office
Chloroplast is the cell's farm
ER is the factory and ribosomes are the workers
Plasma membrane are the city walls
Cilia and flagella are the stirring wheels and propellers
Exosomes and endosomes are the email/post office
January 16, 2025 at 5:28 PM
Mitochondria is the powerhouse of the cell
Chloroplast is the cell's farm
ER is the factory and ribosomes are the workers
Plasma membrane are the city walls
Cilia and flagella are the stirring wheels and propellers
Exosomes and endosomes are the email/post office
Chloroplast is the cell's farm
ER is the factory and ribosomes are the workers
Plasma membrane are the city walls
Cilia and flagella are the stirring wheels and propellers
Exosomes and endosomes are the email/post office
Many thanks for all these terrific insights.
January 12, 2025 at 10:21 PM
Many thanks for all these terrific insights.
Tcf7 activates genes with CTNNB1 (β-catenin)?
What signals are upstream of this? Or are they constitutively active?
What signals are upstream of this? Or are they constitutively active?
January 12, 2025 at 3:13 PM
Tcf7 activates genes with CTNNB1 (β-catenin)?
What signals are upstream of this? Or are they constitutively active?
What signals are upstream of this? Or are they constitutively active?
January 11, 2025 at 2:29 AM
Unrelated request: Would be nice if someone figured out what maintains Tcf7 expression and activity in CD8 stemlike (± mem T cells). It was argued in a recent conference that it's Wnt signaling but I can't see how in the absence of Fzd expression in T cells.
January 10, 2025 at 1:45 PM
Unrelated request: Would be nice if someone figured out what maintains Tcf7 expression and activity in CD8 stemlike (± mem T cells). It was argued in a recent conference that it's Wnt signaling but I can't see how in the absence of Fzd expression in T cells.
Reposted by Mohamed ElTanbouly
Clones usually encompass cell members with heterogenous cell states, too.
January 10, 2025 at 12:54 AM
Clones usually encompass cell members with heterogenous cell states, too.
Makes sense. Thanks for clarifying.
January 10, 2025 at 1:40 PM
Makes sense. Thanks for clarifying.
I think they need Il7r re-expression (and Il2r downregulation)
www.nature.com/articles/ni1...
www.sciencedirect.com/science/arti...
www.nature.com/articles/ni1...
www.sciencedirect.com/science/arti...
Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells - Nature Immunology
Nature Immunology - Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells
www.nature.com
January 10, 2025 at 1:39 PM
I think they need Il7r re-expression (and Il2r downregulation)
www.nature.com/articles/ni1...
www.sciencedirect.com/science/arti...
www.nature.com/articles/ni1...
www.sciencedirect.com/science/arti...
1-This paper?
www.nature.com/articles/s41...
Might you elaborate on where they discussed this (PD-1) here?
I recall they assessed "renewal potential" (Tcm-ness based on prior division no. and quiescence state)
2-Looking forward to reading your group's findings. Sounds very interesting.
www.nature.com/articles/s41...
Might you elaborate on where they discussed this (PD-1) here?
I recall they assessed "renewal potential" (Tcm-ness based on prior division no. and quiescence state)
2-Looking forward to reading your group's findings. Sounds very interesting.
Replicative history marks transcriptional and functional disparity in the CD8+ T cell memory pool - Nature Immunology
Schumacher and colleagues have designed a reporter system that allows in vivo tracking of replicative history over many cell generations. Using this system to study acute T cell responses, they uncove...
www.nature.com
January 9, 2025 at 9:17 PM
1-This paper?
www.nature.com/articles/s41...
Might you elaborate on where they discussed this (PD-1) here?
I recall they assessed "renewal potential" (Tcm-ness based on prior division no. and quiescence state)
2-Looking forward to reading your group's findings. Sounds very interesting.
www.nature.com/articles/s41...
Might you elaborate on where they discussed this (PD-1) here?
I recall they assessed "renewal potential" (Tcm-ness based on prior division no. and quiescence state)
2-Looking forward to reading your group's findings. Sounds very interesting.
They're memory precursors.
When antigen goes away, most clones contract and these cells make up the central memory (Tcm).
In chronic infection, they act as transient amplifiers differentiating into terminal eff and new precursors.
When antigen goes away, most clones contract and these cells make up the central memory (Tcm).
In chronic infection, they act as transient amplifiers differentiating into terminal eff and new precursors.
January 9, 2025 at 3:05 PM
They're memory precursors.
When antigen goes away, most clones contract and these cells make up the central memory (Tcm).
In chronic infection, they act as transient amplifiers differentiating into terminal eff and new precursors.
When antigen goes away, most clones contract and these cells make up the central memory (Tcm).
In chronic infection, they act as transient amplifiers differentiating into terminal eff and new precursors.
1-Incredible figure presentation and clarity
2-Eight years of work
3-Favorite statement (reminded me of another statement in an equally authoritative paper). Both are presented in screenshots below.
4-Builds upon earlier work by Peng et al from Jameson group
www.sciencedirect.com/science/arti...
2-Eight years of work
3-Favorite statement (reminded me of another statement in an equally authoritative paper). Both are presented in screenshots below.
4-Builds upon earlier work by Peng et al from Jameson group
www.sciencedirect.com/science/arti...
December 29, 2024 at 4:41 PM
1-Incredible figure presentation and clarity
2-Eight years of work
3-Favorite statement (reminded me of another statement in an equally authoritative paper). Both are presented in screenshots below.
4-Builds upon earlier work by Peng et al from Jameson group
www.sciencedirect.com/science/arti...
2-Eight years of work
3-Favorite statement (reminded me of another statement in an equally authoritative paper). Both are presented in screenshots below.
4-Builds upon earlier work by Peng et al from Jameson group
www.sciencedirect.com/science/arti...
Thank you :) for the very kind feedback.
I'm still enjoying it so will keep summarizing/reviewing
All the best with your work + life
I'm still enjoying it so will keep summarizing/reviewing
All the best with your work + life
December 22, 2024 at 3:25 PM
Thank you :) for the very kind feedback.
I'm still enjoying it so will keep summarizing/reviewing
All the best with your work + life
I'm still enjoying it so will keep summarizing/reviewing
All the best with your work + life
Could I ask your take on the data showing "Treg conversion to Tfh"?
What (signals) persuades them?
PMID: 39662506
PMID: 19286559
What (signals) persuades them?
PMID: 39662506
PMID: 19286559
December 19, 2024 at 9:11 PM
Could I ask your take on the data showing "Treg conversion to Tfh"?
What (signals) persuades them?
PMID: 39662506
PMID: 19286559
What (signals) persuades them?
PMID: 39662506
PMID: 19286559