pixckypuck.bsky.social
@pixckypuck.bsky.social
Reposted
Analysis shows impaired energy metabolism, upregulated complement system, and dysregulated protein folding. Proteomic changes were associated with #ME/CFS patients’ post-exertional malaise, unrefreshing sleep, and functional capacity.
June 23, 2025 at 10:01 PM
Reposted
#PEM is not just generalized fatigue, but an abnormal worsening of a patient’s baseline symptoms after exposure to physical or cognitive stressors that were normally tolerated before disease onset [3, 4]. The type, intensity, and frequency of PEM symptoms are pmc.ncbi.nlm.nih.gov/articles/PMC...
Epidemiological and clinical factors associated with post-exertional malaise severity in patients with myalgic encephalomyelitis/chronic fatigue syndrome
Post-exertional malaise (PEM), the cardinal feature of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), occurs generally after exposure to a stressor. It is characterized by the worsening ...
pmc.ncbi.nlm.nih.gov
May 29, 2025 at 5:44 AM
Reposted
Great post by @katribertram.bsky.social

I have a section 'Big Phil' in 'Food Fight' on the rise of philanthropy in the nutrition space...which I was compelled to write after reading this quote from BG:

"I was able to find things...like malnutrition...that would not be solved without philanthropy"
May 29, 2025 at 7:50 AM
Reposted
Congrats to @exeter.ac.uk Prof @carolinefwright.bsky.social who has been elected as a Fellow to the Academy! 🎉

Her pioneering work uses genome-wide sequencing to improve diagnosis of rare diseases, helping bring cutting-edge science into everyday healthcare 🌟

👉 ow.ly/6ehl50VXSlc

#AcademyFellows
May 29, 2025 at 8:40 AM
Reposted
Benchmarking And Datasets For Ambient Clinical Documentation: A Review Of Existing Frameworks And Metrics For AI-Assisted Medical Note Generation https://www.medrxiv.org/content/10.1101/2025.01.29.25320859v1
January 30, 2025 at 4:41 AM
Reposted
🆕 Gov’t has responded to the House of Lords Food, Diet and Obesity report

✍ They acknowledge reducing obesity 'will require reshaping the food environment that has caused the rise in obesity.'

😪 Unacceptably, the response fails to accept any of the new recommendations

www.gov.uk/government/p...
Government response to the House of Lords Food, Diet and Obesity Committee’s report 'Recipe for health: a plan to fix our broken food system'
www.gov.uk
January 30, 2025 at 11:14 AM
Reposted
Skeletal muscle adaptations and post-exertional malaise in long COVID www.cell.com/trends/endoc... Rob Wüst et al #PEM #LongCOVID #MECFS
January 30, 2025 at 4:03 PM
Reposted
Muscle fat infiltration predicts heart disease risk better than BMI, study finds ❤️🩺🔬 www.news-medical.net/news/2025012... #Cardiology #HeartHealth #MuscleFat #Cardiovascular #HeartDisease #IMAT #MedicalResearch #Obesity #Health
January 22, 2025 at 4:13 AM
Reposted
Loneliness linked to higher risk of heart disease and stroke and susceptibility to infection
www.sciencedaily.com/releases/202...
January 4, 2025 at 10:34 PM
Reposted
What a cool study and a powerful demonstration that Tuberculosis is largely a disease of poverty. In Brazil a large scale intervention which provided cash monthly to families living in poverty led to profound reductions in TB cases. Up to 50% among the poorest groups.
www.nature.com/articles/s41...
Effects of conditional cash transfers on tuberculosis incidence and mortality according to race, ethnicity and socioeconomic factors in the 100 Million Brazilian Cohort - Nature Medicine
Participation in Brazil’s Bolsa Familia Program, one of the largest conditional cash transfer programs in the world, was associated with large reductions in tuberculosis incidence and mortality among ...
www.nature.com
January 3, 2025 at 8:36 PM
Reposted
GLUCOSE: A Distributional Reinforcement Learning Model for Optimal Glucose Control After Cardiac Surgery https://www.medrxiv.org/content/10.1101/2025.01.01.25319851v1
January 3, 2025 at 7:56 AM
Reposted
Spot Urine Protein to Creatinine Ratio in Patients with Urinary Tract Infection https://www.medrxiv.org/content/10.1101/2024.12.29.24319746v1
January 3, 2025 at 8:17 AM
Reposted
70% of the world’s population has universal healthcare, but not the US

We are the only highly developed nation without it

Our healthcare is twice as expensive as the average wealthy nation

US ranks last among industrial nations for deaths that could be prevented with timely access to healthcare
January 2, 2025 at 1:26 PM
Reposted
This study, sponsored by the WE&ME Foundation, is being conducted by the Department of Primary Care Medicine at the Center for Public Health of the Medical University of Vienna, by the Department of Mathematics of the University of Vienna and by the Austrian Society s2survey.net/pais/index.p...
Questionnaire | page 1
s2survey.net
December 29, 2024 at 2:50 PM
Reposted
20 years ago today, a tiny neutron star reached halfway across the galaxy and slammed our planet with a gamma-ray hammer.

www.scientificamerican.com/article/an-e...

🧪🔭
An Earth-Rocking Cosmic Explosion Turns 20
Twenty years ago today a magnetar’s epic tantrum made our planet ring like a bell from tens of thousands of light-years away
www.scientificamerican.com
December 27, 2024 at 4:23 PM
Reposted
SoK: Intelligent Detection for Polycystic Ovary Syndrome(PCOS) https://www.medrxiv.org/content/10.1101/2024.12.25.24319623v1
December 28, 2024 at 10:58 AM
Reposted
More evidence that mitochondrial dysfunction is a major aftermath associated with SARS-CoV-2 infection as the impaired Mitochondria lead to an accumulation of reactive oxygen species (ROS), triggering endothelial dysfunction, and leading to the passage of harmful
www.nature.com/articles/s41...
Omics-based analysis of mitochondrial dysfunction and BBB integrity in post-COVID-19 sequelae - Scientific Reports
Scientific Reports - Omics-based analysis of mitochondrial dysfunction and BBB integrity in post-COVID-19 sequelae
www.nature.com
December 28, 2024 at 5:28 PM
Reposted
Key Pathophysiological Role of Skeletal Muscle Disturbance in Post COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Accumulated Evidence onlinelibrary.wiley.com/doi/10.1002/... @scheibenbogen.bsky.social & K. Wirth #MECFS
Key Pathophysiological Role of Skeletal Muscle Disturbance in Post COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Accumulated Evidence
Background Recent studies provide strong evidence for a key role of skeletal muscle pathophysiology in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). In a 2021 review article on the pa...
onlinelibrary.wiley.com
December 27, 2024 at 3:03 PM
Reposted
Tacling persistent neurological symptoms in patients following acute COVID-19 infenction: an update of the literature www.tandfonline.com/doi/full/10....

5.3. Myalgic encephalomyelitis/chronic fatigue syndrome and long COVID

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic
Tackling persistent neurological symptoms in patients following acute COVID-19 infection: an update of the literature
The COVID-19 pandemic has taught myriad lessons and left several questions we are yet to comprehend. Initially, the scientific community was concerned with the management of acute disease and immun...
www.tandfonline.com
December 26, 2024 at 11:47 PM
Reposted
The protein WASF3 is linked to myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS):
Higher levels of WASF3
Researchers found that #pwME have higher levels of WASF3 in their muscle cells than healthy people.
Impaired mitochondrial function
WASF3 disrupts the
www.nih.gov/news-events/...
Protein may be linked to exercise intolerance in ME/CFS
A study suggested that high levels of a protein may reduce energy production in the muscle cells of people with ME/CFS.
www.nih.gov
December 15, 2024 at 5:55 PM
Reposted
“What doesn’t kill you, can disable you for the rest of your life.” Ask ME and all the #pwME pre & post COVID-19, how I/we know and read the extensive & scientific literature on it: www.science.org/doi/10.1126/... @michaelpelusomd.bsky.social et al.
Infection-associated chronic conditions: Why Long Covid is our best chance to untangle Osler’s web
A research agenda that studies Long Covid in the context of related conditions could transform our understanding of these disabling illnesses.
www.science.org
December 15, 2024 at 6:34 PM