Love Nebraska so much, these lines always give me the chills:

"Now my ma she fingers her wedding band
And watches the salesman stare at my old man's hands
He's tellin' us all 'bout the break he'd give us
If he could but he just can't
Well if I could I swear I know just what I'd do"

2/2 So, some TCR may be more prone to become Tregs or whatnot, but without tracking responses to the same epitope for different TCR it's really hard to know if there is TCR determinism (which I have no issue with) versus some facet of the stimulation (loosely "environmental") that drives this.

1/2 This is a very nice paper but I'm not sure I agree fully with the conclusion (reading on the train on my phone, may have missed something). To my mind, this data shows that a given TCR will repeatedly adopt a particular cell fate when encountering the same antigen derived from the same source.

Was it ever alive? I joined because I heard it was like old Twitter but I never see much in the way of decent science conversation on here. Maybe people have just abandoned social media.

It's more than 20 years old, so obviously doesn't discuss many of the amazing discoveries since, prominent among them being the tissue repair functions of Tregs, identifying them as immune system regulators not merely suppressor T cells.

I think, Fiona Powrie, Ethan Shevach, Jeff Bluestone, Diane Mathis and Christoph Benoist all would lay claim too. Don Mason is dead, but he probably started his studies in the area at a similar time to Sakaguchi.

All praise to him is well warranted.

It is strange that there hasn't been an award for T cells/B cells, given that there is sufficient consensus that Miller and Cooper could share it.

The mention of Sakaguchi alone was cold, Jeff 😂

I'm also expecting that the number of submissions from "the elite" will increase as their hit rate drops, and so the effective payline will likely be worse as the competition within a given study section increases.

And what is a reviewer morally obligated to do? Is scoring the way we're meant to a bigger dereliction of duty than driving score compression.