Caitlin O'Connor, PhD
@pharmacocaitlin.bsky.social
Research Assistant Professor in the Narla Lab at the University of Michigan. Opinions are my own. (she/her)
By combining a new PP2A molecular glue (PMG) with either G12Ci or MEKi we can induce tumor regressions, significantly extend median survival, and prevent acquired resistance in mouse models. Check it out:
www.jci.org/articles/vie...
www.jci.org/articles/vie...
JCI -
A PP2A molecular glue overcomes ras/mapk inhibitor resistance in kras-mutant non-small cell lung cancer
www.jci.org
October 17, 2025 at 12:32 PM
By combining a new PP2A molecular glue (PMG) with either G12Ci or MEKi we can induce tumor regressions, significantly extend median survival, and prevent acquired resistance in mouse models. Check it out:
www.jci.org/articles/vie...
www.jci.org/articles/vie...