Excited to share the beautiful biology uncovered in our latest #Candida #auris study! 🌱🧬 Check out the paper: doi.org/10.1016/j.ce... and listen to the AI DeepDive podcast for more insights: 😜https://youtu.be/4NlM7_uqOLw?si=4t21kDaObgce01M3
@cp-cellreports.bsky.social @cellpress.bsky.social

We conducted in-depth genetic analysis and generated multiple mutants to establish a regulatory model involving Wor1, Msn4, Crz5, Rca1, and Efg1—revealing distinct regulatory logic compared to Candida albicans. 6/n

Importantly, most derivative clones show reduced switching frequency and altered coloration vs. the original strain. Stress and antifungal assays reveal broad variation. Notably, the Brown morphotype shows higher mutation rates and reduced fitness in vitro and in vivo. 5/n

This striking colony diversity emerges even among derivative clones from a single clinical strain after 2 weeks of switching. While mutation accumulation may play a role, high-frequency morphotypes suggest possible epigenetic regulation or multistage switching. 4/n

Switching behavior varies significantly across clinical strains, both in colony coloration and switching frequency, potentially reflecting differences in genetic background. BUT interestingly .... 3/n

doi.org/10.1016/j.ce... 🎉 We screened 120 + clinical strains across all five clades and discovered high-frequency phenotypic switching. Beyond classic white‑opaque switching, multiple morphotypes with diverse colony colors emerge—likely driving clinical variability. 2/n

Thrilled to share our latest in
@cp-cellreports.bsky.social
: White–Brown switching in #Candida #auris is now out! This may be the first comprehensive study of epigenetic switching in #auris, shedding light on clinical variability in virulence and antifungal resistance. Link in comment! 1/n

At the very beginning of my PhD, I approached most experiments like a child playing in a garden—exploring with curiosity and excitement.
Check it out: Rapid in vitro evolution of flucytosine resistance in Candida auris
1/4

A Collaboration Paper with Philipp:
“HDAC1 Fine-Tunes Th17 Polarization In Vivo to Restrain Tissue Damage in Fungal Infections”
www.cell.com/cell-reports...

I’m excited to share our collaborative work focusing on the multiomics landscape of #Aspergillus-Klebsiella interactions, published in #CommunicationsBiology. It was a lot of fun to explore how fungi and bacteria respond to each other.
Paper: www.nature.com/articles/s42...

It’s scary to see how Candida auris has evolved to adapt to climate changes. We recently found that C. auris has a strong ability to fix ambient CO2 (www.biorxiv.org/content/10.1...).

🔑 #fungalevolution Candida auris can generate a pooled population with diverse phenotypes from a single parental strain.

PLOS Pathogens: journals.plos.org/plospathogen...

#Candidaauris #Candida #infectiousdisease #morphogenesis #climatechange