Trinh Phan-Canh
@phancanhtrinh.bsky.social
Scienceholic at @MaxPerutzLabs | PhD student @MedUni_Wien | MS & BS Pharmacy UMP | BS Informatics VNU | Former UMP Lecturer | QuocHoc_Hue Alumni
🚨 New publication! A tiny switch with big consequences: PhD student Trinh Phan-Canh reveals in @cp-cellreports.bsky.social that Candida auris shifts between White and Brown phenotypes – a change that impacts both drug resistance and virulence ➡️ tinyurl.com/6f2nm268
@meduniwien.ac.at
@meduniwien.ac.at
August 4, 2025 at 8:36 AM
🚨 New publication! A tiny switch with big consequences: PhD student Trinh Phan-Canh reveals in @cp-cellreports.bsky.social that Candida auris shifts between White and Brown phenotypes – a change that impacts both drug resistance and virulence ➡️ tinyurl.com/6f2nm268
@meduniwien.ac.at
@meduniwien.ac.at
Reposted by Trinh Phan-Canh
White-Brown switching controls phenotypic plasticity and virulence of Candida auris
White-Brown switching controls phenotypic plasticity and virulence of Candida auris
Using transcriptomics and reverse genetics, Phan-Canh et al. present a comprehensive analysis of genes governing phenotypic White-Brown switching in the multidrug-resistant fungal pathogen Candida auris. White and Brown morphotypes exhibit distinct stress responses and virulence traits, linked to complex gene regulatory networks that govern the phenotypic plasticity during fungal infections.
dlvr.it
July 17, 2025 at 7:50 PM
White-Brown switching controls phenotypic plasticity and virulence of Candida auris
Reposted by Trinh Phan-Canh
White-Brown switching controls phenotypic plasticity and virulence of #Candida auris: Cell Reports www.cell.com/cell-reports...
White-Brown switching controls phenotypic plasticity and virulence of Candida auris
Using transcriptomics and reverse genetics, Phan-Canh et al. present a comprehensive
analysis of genes governing phenotypic White-Brown switching in the multidrug-resistant
fungal pathogen Candida aur...
www.cell.com
July 21, 2025 at 4:55 AM
White-Brown switching controls phenotypic plasticity and virulence of #Candida auris: Cell Reports www.cell.com/cell-reports...
Thrilled to share our latest in
@cp-cellreports.bsky.social
: White–Brown switching in #Candida #auris is now out! This may be the first comprehensive study of epigenetic switching in #auris, shedding light on clinical variability in virulence and antifungal resistance. Link in comment! 1/n
@cp-cellreports.bsky.social
: White–Brown switching in #Candida #auris is now out! This may be the first comprehensive study of epigenetic switching in #auris, shedding light on clinical variability in virulence and antifungal resistance. Link in comment! 1/n
July 12, 2025 at 10:52 AM
Thrilled to share our latest in
@cp-cellreports.bsky.social
: White–Brown switching in #Candida #auris is now out! This may be the first comprehensive study of epigenetic switching in #auris, shedding light on clinical variability in virulence and antifungal resistance. Link in comment! 1/n
@cp-cellreports.bsky.social
: White–Brown switching in #Candida #auris is now out! This may be the first comprehensive study of epigenetic switching in #auris, shedding light on clinical variability in virulence and antifungal resistance. Link in comment! 1/n
Has anyone experienced unusually slow performance from the Candida Genome Database this week? #CandidaGenomeDatabase
June 20, 2025 at 12:07 PM
Has anyone experienced unusually slow performance from the Candida Genome Database this week? #CandidaGenomeDatabase
Reposted by Trinh Phan-Canh
AlphaFold’s highly accurate structural models transformed protein biology. Nature reports on the efforts to create a similar system for RNA and why it’s a tougher nut to crack. #RNAsky 🧪
RNA function follows form – why is it so hard to predict?
AlphaFold’s highly accurate structural models transformed protein biology,but RNA lags behind.
go.nature.com
March 30, 2025 at 1:36 PM
AlphaFold’s highly accurate structural models transformed protein biology. Nature reports on the efforts to create a similar system for RNA and why it’s a tougher nut to crack. #RNAsky 🧪
A short letter in which I demonstrated that phosphatidylinositol transfer protein Pdr16 is responsible for azole resistance in Candida auris. The upregulation of these proteins may also be involved in resistance to amphotericin B and flucytosine.
journals.asm.org/doi/10.1128/...
journals.asm.org/doi/10.1128/...
Gene dosage of PDR16 modulates azole susceptibility in Candida auris | Microbiology Spectrum
Candida auris is a human fungal pathogen of utmost medical relevance exhibiting exceptionally high
resistance to all clinically used antifungal drugs, including azoles, polyenes, and
echinocandins as ...
journals.asm.org
March 26, 2025 at 12:38 PM
A short letter in which I demonstrated that phosphatidylinositol transfer protein Pdr16 is responsible for azole resistance in Candida auris. The upregulation of these proteins may also be involved in resistance to amphotericin B and flucytosine.
journals.asm.org/doi/10.1128/...
journals.asm.org/doi/10.1128/...
Reposted by Trinh Phan-Canh
#TEsky The domesticated transposon protein L1TD1 associates with its ancestor L1 ORF1p to promote LINE-1 retrotransposition doi.org/10.7554/eLif...
The domesticated transposon protein L1TD1 associates with its ancestor L1 ORF1p to promote LINE-1 retrotransposition
DNA hypomethylation in human tumor cells results in the activation of the LINE-1-derived RNA-binding protein L1TD1 and its interactions with LINE-1 transposons.
doi.org
March 21, 2025 at 3:14 PM
#TEsky The domesticated transposon protein L1TD1 associates with its ancestor L1 ORF1p to promote LINE-1 retrotransposition doi.org/10.7554/eLif...
Reposted by Trinh Phan-Canh
My group @aps-hki.bsky.social is looking for a new postdoc in immunology of fungal infections focusing on vulvovaginal candidiasis. Please contact me for further details in case of interest.
March 19, 2025 at 5:55 PM
My group @aps-hki.bsky.social is looking for a new postdoc in immunology of fungal infections focusing on vulvovaginal candidiasis. Please contact me for further details in case of interest.
At the very beginning of my PhD, I approached most experiments like a child playing in a garden—exploring with curiosity and excitement.
Check it out: Rapid in vitro evolution of flucytosine resistance in Candida auris
1/4
Check it out: Rapid in vitro evolution of flucytosine resistance in Candida auris
1/4
March 19, 2025 at 10:54 AM
At the very beginning of my PhD, I approached most experiments like a child playing in a garden—exploring with curiosity and excitement.
Check it out: Rapid in vitro evolution of flucytosine resistance in Candida auris
1/4
Check it out: Rapid in vitro evolution of flucytosine resistance in Candida auris
1/4
Reposted by Trinh Phan-Canh
AI for modelling infectious disease epidemics https://www.nature.com/articles/s41586-024-08564-w (read free: https://rdcu.be/eaA6O) 🧬🖥️🧪
February 20, 2025 at 9:54 AM
AI for modelling infectious disease epidemics https://www.nature.com/articles/s41586-024-08564-w (read free: https://rdcu.be/eaA6O) 🧬🖥️🧪
As I approach the final stages of my PhD, I find myself overwhelmed by many potential ideas and ambitious projects that come to mind every day. However, it’s time to put a stop to it— I need to go further.
December 28, 2024 at 12:08 PM
As I approach the final stages of my PhD, I find myself overwhelmed by many potential ideas and ambitious projects that come to mind every day. However, it’s time to put a stop to it— I need to go further.
A Collaboration Paper with Philipp:
“HDAC1 Fine-Tunes Th17 Polarization In Vivo to Restrain Tissue Damage in Fungal Infections”
www.cell.com/cell-reports...
“HDAC1 Fine-Tunes Th17 Polarization In Vivo to Restrain Tissue Damage in Fungal Infections”
www.cell.com/cell-reports...
December 1, 2024 at 11:53 AM
A Collaboration Paper with Philipp:
“HDAC1 Fine-Tunes Th17 Polarization In Vivo to Restrain Tissue Damage in Fungal Infections”
www.cell.com/cell-reports...
“HDAC1 Fine-Tunes Th17 Polarization In Vivo to Restrain Tissue Damage in Fungal Infections”
www.cell.com/cell-reports...
I’m excited to share our collaborative work focusing on the multiomics landscape of #Aspergillus-Klebsiella interactions, published in #CommunicationsBiology. It was a lot of fun to explore how fungi and bacteria respond to each other.
Paper: www.nature.com/articles/s42...
Paper: www.nature.com/articles/s42...
November 15, 2024 at 8:31 PM
I’m excited to share our collaborative work focusing on the multiomics landscape of #Aspergillus-Klebsiella interactions, published in #CommunicationsBiology. It was a lot of fun to explore how fungi and bacteria respond to each other.
Paper: www.nature.com/articles/s42...
Paper: www.nature.com/articles/s42...
🔑 #fungalevolution Candida auris can generate a pooled population with diverse phenotypes from a single parental strain.
PLOS Pathogens: journals.plos.org/plospathogen...
#Candidaauris #Candida #infectiousdisease #morphogenesis #climatechange
PLOS Pathogens: journals.plos.org/plospathogen...
#Candidaauris #Candida #infectiousdisease #morphogenesis #climatechange
November 15, 2024 at 8:15 PM
🔑 #fungalevolution Candida auris can generate a pooled population with diverse phenotypes from a single parental strain.
PLOS Pathogens: journals.plos.org/plospathogen...
#Candidaauris #Candida #infectiousdisease #morphogenesis #climatechange
PLOS Pathogens: journals.plos.org/plospathogen...
#Candidaauris #Candida #infectiousdisease #morphogenesis #climatechange