The Lewis Lab
@peterlewislab.bsky.social
Chromatin biochemistry and genomics in development and cancer. UW-Madison School of Medicine and Public Health
TheLewisLab.net
TheLewisLab.net
Our results support a model where SUZ12-NBD interactions with RNA act as a kinetic buffer, limiting PRC2 activity and ensuring specific targeting to CpG islands. Loss of the NBD (VEFS) disrupts this equilibrium, driving widespread, non-specific H3K27me3 deposition. 13/13
July 23, 2025 at 11:38 PM
Our results support a model where SUZ12-NBD interactions with RNA act as a kinetic buffer, limiting PRC2 activity and ensuring specific targeting to CpG islands. Loss of the NBD (VEFS) disrupts this equilibrium, driving widespread, non-specific H3K27me3 deposition. 13/13