@pekka-katajisto.bsky.social
Hien’s peroxisome story is out! Amazing effort starting from description of a new phenomenon, building in vivo tools, and describing how sub-cellular localization of metabolic activities can guide stem cell fate. Congrats Hien and thank you to the great collaborators!
Happy to present Hien’s paper on age-selective apportioning of peroxisomes as a fate determinant in adult stem cells www.nature.com/articles/s41... @metastem.bsky.social @helsinki.fi @ki.se @helsinki-biotech.bsky.social out now in @natcomms.nature.com
A thread 🧵 1/9
A thread 🧵 1/9
Glucose-6-phosphate-dehydrogenase on old peroxisomes maintains self-renewal of epithelial stem cells after asymmetric cell division - Nature Communications
Peroxisomes are essential but their role in cell fate regulation remains understudied. Here, the authors reveal that young and old peroxisomes are not equally distributed in asymmetrically dividing st...
www.nature.com
April 28, 2025 at 8:24 PM
Hien’s peroxisome story is out! Amazing effort starting from description of a new phenomenon, building in vivo tools, and describing how sub-cellular localization of metabolic activities can guide stem cell fate. Congrats Hien and thank you to the great collaborators!
Reposted
1/6 Proudly presenting Sharif’s @sharifiqbal.bsky.social paper on the role of Asporin in intestinal regeneration through TGF-B-dependent fetal-like reversion www.sciencedirect.com/science/arti... out in @cp-cellstemcell.bsky.social @pekka-katajisto.bsky.social @helsinki.fi @metastem.bsky.social 🧵
Fetal-like reversion in the regenerating intestine is regulated by mesenchymal asporin
Mesenchymal cells and the extracellular matrix (ECM) support epithelium during homeostasis and regeneration. However, the role of the mesenchyme in ep…
www.sciencedirect.com
March 7, 2025 at 12:30 PM
1/6 Proudly presenting Sharif’s @sharifiqbal.bsky.social paper on the role of Asporin in intestinal regeneration through TGF-B-dependent fetal-like reversion www.sciencedirect.com/science/arti... out in @cp-cellstemcell.bsky.social @pekka-katajisto.bsky.social @helsinki.fi @metastem.bsky.social 🧵