Paul Sax
@paulsaxmd.bsky.social
Harvard/Brigham Infectious Diseases doctor, writer, educator. Editor of Clinical Infectious Diseases. Prefer baseball to football, pizza to sushi, dogs to cats, Beatles to Stones. https://blogs.jwatch.org/hiv-id-observations/
Thanks, Paul! It will still mostly be ID-themed, but with less esoterica for a broader audience. And longer, more personal. At least that's how I'm planning it right now.
October 25, 2025 at 8:08 PM
Thanks, Paul! It will still mostly be ID-themed, but with less esoterica for a broader audience. And longer, more personal. At least that's how I'm planning it right now.
Here's the personal note ... 😢 open.substack.com/pub/paulsaxm...
Louie's Last Day
Remembering Louie, and the gifts dogs give us.
open.substack.com
October 17, 2025 at 3:34 PM
Here's the personal note ... 😢 open.substack.com/pub/paulsaxm...
Do you think clofazimine works? I can't think of a single clinical trial where a clofazimine vs a non-clofazimine arm showed that the clofazimine arm did better.
Yes, we use it -- but it sure would be nice to see some robust evidence that it's worth it.
Yes, we use it -- but it sure would be nice to see some robust evidence that it's worth it.
October 7, 2025 at 9:23 PM
Do you think clofazimine works? I can't think of a single clinical trial where a clofazimine vs a non-clofazimine arm showed that the clofazimine arm did better.
Yes, we use it -- but it sure would be nice to see some robust evidence that it's worth it.
Yes, we use it -- but it sure would be nice to see some robust evidence that it's worth it.
Very well put! So sad.
(Your dog and Louie could be related ...)
(Your dog and Louie could be related ...)
September 26, 2025 at 8:33 PM
Very well put! So sad.
(Your dog and Louie could be related ...)
(Your dog and Louie could be related ...)
Thanks, Ilan. It's not good news from the work-up, as suspected. He probably has only a few days or weeks left.
(That's a really cute photo of Ricotta!)
(That's a really cute photo of Ricotta!)
September 26, 2025 at 8:32 PM
Thanks, Ilan. It's not good news from the work-up, as suspected. He probably has only a few days or weeks left.
(That's a really cute photo of Ricotta!)
(That's a really cute photo of Ricotta!)
Personally haven't used interferon for HCV in over a decade -- not since the great rush of HCV antivirals from 2013-16. Even when battling for insurance coverage, we knew that eventually we could treat people without this incredibly toxic (and not very effective) drug.
September 24, 2025 at 12:03 PM
Personally haven't used interferon for HCV in over a decade -- not since the great rush of HCV antivirals from 2013-16. Even when battling for insurance coverage, we knew that eventually we could treat people without this incredibly toxic (and not very effective) drug.
Hooray! Working on this one clinician at a time ... next up, "DAAs" for HCV!
C'mon, when was the last time someone used a something other than a "directly acting" antiviral for HCV?
C'mon, when was the last time someone used a something other than a "directly acting" antiviral for HCV?
September 23, 2025 at 9:22 PM
Hooray! Working on this one clinician at a time ... next up, "DAAs" for HCV!
C'mon, when was the last time someone used a something other than a "directly acting" antiviral for HCV?
C'mon, when was the last time someone used a something other than a "directly acting" antiviral for HCV?