Paul Flicek
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paulflicek.bsky.social
Paul Flicek
@paulflicek.bsky.social
Data, genomics, evolution, science 🇺🇸🇬🇧
Reposted by Paul Flicek
My lab at hiring! - we have TWO postdoc positions (one computational, one wet lab focussed) at Yale @yaleschoolofmed.bsky.social, working closely with our group members at University of Cambridge, UK @cambridgeuni.bsky.social

Please help to spread the word!

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March 26, 2025 at 3:31 PM
Celebrating all of the amazing women in science I've had as mentors, role models, colleagues and friends 🧬👩‍💻🧪
February 12, 2025 at 2:07 AM
A phenomenal effort to bring this together with so many interesting aspects of how genetic background influences cancer development. I'm honoured to have been part of this project!
January 15, 2025 at 7:51 PM
Reposted by Paul Flicek
🌟NEW PREPRINT ALERT!🌟

We are very pleased to introduce #StrainDifferences: “Genetic background sets the trajectory of cancer evolution”

www.biorxiv.org/content/10.1...

🧵[1/12]
Genetic background sets the trajectory of cancer evolution
Human cancers are heterogeneous. Their genomes evolve from genetically diverse germlines in complex and dynamic environments, including exposure to potential carcinogens. This heterogeneity of humans,...
www.biorxiv.org
January 15, 2025 at 7:19 PM
Reposted by Paul Flicek
Reposted by Paul Flicek
Abstract submissions are still open for the CSHL Network Biology meeting in March 11 - 15 2025 (abstract deadline: Jan 10). A large fraction of talks will be selected from the abstracts. On behalf of the organizers, we look forward to welcoming you there.
meetings.cshl.edu/meetings.asp...
November 26, 2024 at 1:17 PM
I’ve just read this pre-print and it’s fantastic. A conserved element with no endogenous enhancer activity is nonetheless necessary and sufficient for extreme long range enhancer action. Recommend to anyone interested in gene regulation
REX - a mammalian "range extender" element that can turn short-distance enhancers into long-distance enhancers.

New preprint from a collaboration led by Grace Bower and Evgeny Kvon.

doi.org/10.1101/2024...
November 13, 2024 at 9:15 PM
This looks like a great meeting! In a great place too
Interested in difficult to access parts of genetics, cellular & structural biology? Join us in Edinburgh 2-4th April 2025 for "Hidden Cell, Dark Genome"
Regulation in the dark genome
Uncharted proteins, RNA complexity
Atomic structures at cellular scale
Cell diversity
www.ed.ac.uk/c/hidden-cel...
November 12, 2024 at 11:15 AM
The events of this week suggest that the excitement and hype around AI in science won’t be dying down anytime soon
October 9, 2024 at 1:36 PM
Reposted by Paul Flicek
8/tl;dr: In most situations, it is to the author's maximal benefit to license their manuscripts thusly:

preprints: any CC license
journal publication: CC BY only

🧪 #AcademicSky
October 5, 2024 at 10:03 PM
Celebrate #DNADay by reading the comic (and scientifically accurate 🧪) adventures from Cell Town, home of Pol, Hely, Topy, and the Repair Squad as they set out on another round of cell division! drive.google.com/drive/folder...
Whats wrong with this DNA? ENG - Google Drive
drive.google.com
April 25, 2024 at 8:57 PM
Reposted by Paul Flicek
The use of the phrase “ancestry-specific variant” is increasing, particularly to describe rare Single-nucleotide variants (SNVs). But these alleles are not ancestry-specific. They have not yet been found elsewhere, but they will be. 1/n
February 28, 2024 at 1:44 PM
Reposted by Paul Flicek
At the forefront of research involving long-read sequence data, JAX's @christinebeck.bsky.social & Peter Audano discuss how adjustments to the technical and analytical infrastructure are needed. Read more in their recent Genome Research paper 🧪🤝🖥️ 🧬 :
www.jax.org/news-and-ins...
Improving whole genome sequence data analyses
Christine Beck and Peter Audano are at the forefront of research involving long-read sequence data. They are particularly interested in structural variants, where segments of the genome are deleted, i...
www.jax.org
February 22, 2024 at 6:56 PM