Lol @mads100tist.bsky.social. We've tried a number things for mass culture over the years, like self-enclosed "worm balls". But the reality is that running for the hills is a young-male's game.

Great work led by @rosealsaadi.bsky.social and @hlewack.bsky.social

I don’t need to tell you, but one cool scaffolding idea is to take one example and to return to it at each stage of the course to slowly unpeel the genetics onion. Mouse coat color is perfect for that because you can go from transmission to molecular to biochemistry to population genetics.

Bateson and Punnett’s first example was rooster combs, which is cool. Mouse coat color is great because you can tie it directly to molecular function that explains the epistasis. Check out my 2008 NRG paper for examples and pictures. Also plant examples if you are into that kind of thing 😁

"Random" variation in just a handful of genes explains differences in reproductive outcomes across genetically identical individuals. It's Ground Hog Day or Midnight Library for worms — if those stories also revealed epigenetic associations (I'm sure they were supposed to be in there someplace).

Although other work, which I have also never published, shows that this domain can be much bigger than you would expect. (Other than that Dr. Fermat, how is your research going).

The situation that you describe is the physical manifestation of of that more general principle. And of course it will almost always be true within a certain small chromosomal region, say within the confounds of a gene.

Something that I discovered as a graduate student, but have never published. Formally, from a statistical point of view, dominance and epistasis are only distinguishable under linkage equilibrium. Otherwise they are confounded.

You become twice as spicy every ten years.

Your next, much more major test, is the Baroque Cycle, which I loved, but boy does it take a while to get rolling. I read these books and then read Cryptonomicon because I wanted to follow the story. This has to be the most oblique prequel ever written. Great read for scientists in particular.