Patrick Phillips
patrickphillips.bsky.social
Patrick Phillips
@patrickphillips.bsky.social
3.2K followers 590 following 150 posts
Geneticist at University of Oregon @uoregon. Worms, C. elegans, aging, evolution, genetics, genomics, complex traits. Former provost and interim president. Lab: https://pages.uoregon.edu/pphil/ GScholar: https://scholar.google.com/citations?user=JbH6mVkAAA
Posts Media Videos Starter Packs
Pinned
An update of our latest research push. We study the genetic basis of natural variation using nematodes and theory, and have been using that variation to study the biology of aging. I am now convinced that the next era in both evolutionary biology and aging requires new biology: synthetic biology 1/2
Reposted by Patrick Phillips
DAF-2/IGF-1 degradation: Males WAY outlive hermaphrodites! This is so cool. @patrickphillips.bsky.social
Lol @mads100tist.bsky.social. We've tried a number things for mass culture over the years, like self-enclosed "worm balls". But the reality is that running for the hills is a young-male's game.
bsky.app
Make males live more than 400% longer and prevent sexual disfunction late in life?! We're down with it. Our latest preprint: Disruption of the insulin signaling pathway in C. elegans dramatically increases male longevity and enhances reproductive health late in life. www.biorxiv.org/content/10.1...
Inspired by my recent workshop visit in Sicily, the lab had an Italian food potluck during lab meeting. I made pumpkin stuffed gnocchi in a nutmeg sage cream sauce, but we have no kitchen. So I finished the gnocchi in an electric tea kettle. Worked ok.
Grew up a huge Dodgers fan but the last serious game I watched was in grad school when Kurt Gibson made the greatest hit I’ve ever seen. So yes, I’ve turned on this baby after seeing the hoopla.
Happened to wear black today, so I got sucked into a lab Louvre heist Halloween dress up.
This is nuts, because we know that we can use synthetic biology to optimize these “beasts” of burden. Not sure of the application. I have visions bacterially manned gates sorting the worthiness of other bacteria.
Domesticated animals have pulled our heavy carts and turned our large mills for centuries. But what about the opposite end of the spectrum—what if the wheel you want to turn is so small you can’t see it?

Turns out we can harness the power of bacteria to power the world’s smallest machines.

1/7 ⚛️🧪
Reposted by Patrick Phillips
I'm recruiting a postdoc for my group (based in beautiful Eugene, OR). Please get in touch if you're interested, esp if you'd like to chat at #ASHG25!
We'll primarily work at the intersection of statistical and population genetics, and we also have active projects related to the ethical and social implications of human genetics (ELSI). Please get in touch if that's a combination that sounds interesting to you!
Reposted by Patrick Phillips
Available to read via #OpenAccess
The egg-counter: a novel microfluidic platform for characterization of Caenorhabditis elegans egg-laying
pubs.rsc.org/en/content/a...
Patrick C. Phillips et al
@patrickphillips.bsky.social @uoregon.bsky.social @stephenbanse.bsky.social
Very important paper for the geroscience hypothesis. Healthy aging is critical, even in the face of obvious disease states.
🧬💥 Do the genetics that make you develop a disease also help you survive it? Not much.

Our new study in Nature Genetics including 9 disease and 7 biobanks shows:

• Susceptibility variants ≠ survival
• PRSs for onset weak at predicting progression
• Lifespan PRS predicts survival better
I don’t need to tell you, but one cool scaffolding idea is to take one example and to return to it at each stage of the course to slowly unpeel the genetics onion. Mouse coat color is perfect for that because you can go from transmission to molecular to biochemistry to population genetics.
Bateson and Punnett’s first example was rooster combs, which is cool. Mouse coat color is great because you can tie it directly to molecular function that explains the epistasis. Check out my 2008 NRG paper for examples and pictures. Also plant examples if you are into that kind of thing 😁
Reposted by Patrick Phillips
Save the date! #PEQG26 June 9-12 2026 in Asilomar, CA. Happens only every 2yrs, but is my favorite conference. Full website coming soon, and registration and abstract submission opens November 14, but I'm allowed to tease that keynotes will be @jnovembre.bsky.social @jennytung.bsky.social and me!
Homepage - Population, Evolutionary, and Quantitative Genetics Conference
Visit our website to learn more.
genetics-gsa.org
"Random" variation in just a handful of genes explains differences in reproductive outcomes across genetically identical individuals. It's Ground Hog Day or Midnight Library for worms — if those stories also revealed epigenetic associations (I'm sure they were supposed to be in there someplace).
Just out in press in eLife, a cool and brilliant piece of work by @amywebster.bsky.social: Gene expression variation across genetically identical individuals predicts reproductive traits. elifesciences.org/articles/106...
Although other work, which I have also never published, shows that this domain can be much bigger than you would expect. (Other than that Dr. Fermat, how is your research going).
The situation that you describe is the physical manifestation of of that more general principle. And of course it will almost always be true within a certain small chromosomal region, say within the confounds of a gene.
Something that I discovered as a graduate student, but have never published. Formally, from a statistical point of view, dominance and epistasis are only distinguishable under linkage equilibrium. Otherwise they are confounded.
You become twice as spicy every ten years.
Your next, much more major test, is the Baroque Cycle, which I loved, but boy does it take a while to get rolling. I read these books and then read Cryptonomicon because I wanted to follow the story. This has to be the most oblique prequel ever written. Great read for scientists in particular.
New position in Developmental Neuroscience in the University of Oregon Department of Biology. There is also a neuroengineering search going on in the Knight Campus at the same time, so exciting buildouts in that area at the UO. academicjobsonline.org/ajo/jobs/30255
University of Oregon, Department of Biology
Job #AJO30255, 535561 Assistant Professor of Developmental Neuroscience, Department of Biology, University of Oregon, Eugene, Oregon, US
academicjobsonline.org
Reposted by Patrick Phillips
Come be my boss! My dept. at GT is searching for a new chair. Drop me a line if you are interested, I'd be happy to talk about this position, GT, ATL- anything. It's a drama-free department filled with cool people in a dynamic city.

www.biosciences.gatech.edu/chair-search
Chair Search
Chair, School of Biological Sciences Georgia Institute of Technology, Atlanta The School of Biological Sciences of the Georgia Institute of Technology (“Georgia Tech”) invites applications for the pos...
www.biosciences.gatech.edu
Reposted by Patrick Phillips
Bittersweet to be leaving @docedge.bsky.social after a wonderful postdoc, but excited to share that I'm joining @uoregon.bsky.social next month as an Assistant Professor in the Department of Data Science.
Reposted by Patrick Phillips
Congress says they have our back...let's hold them to their word!

All gas, no breaks this August with the 31 Days of Action campaign.

Sign up for our daily action notes here: act.standupforscience.net/forms/31-day...