patrickmsexton1.bsky.social
@patrickmsexton1.bsky.social
Reposted
The PDB files for the TSC:WIPI3 complex have been released today at the PDB. At 40nm across, it is well worth a look 😀🧪

www.rcsb.org/structure/9CE3
RCSB PDB - 9CE3: Structure of the TSC:WIPI3 lysosomal recruitment complex
Structure of the TSC:WIPI3 lysosomal recruitment complex
www.rcsb.org
December 4, 2024 at 8:15 AM
Reposted
The PDBs for our TSC structure are now available!

To put the size of TSC in perspective, here's a ribosome... this thing is enormous. 🤩

#cryoEM #mTORC1 #TSC

rcsb.org/3d-view/9CE3
science.org/doi/10.1126/sciadv.adr5807
@luptoncj.bsky.social
December 7, 2024 at 3:33 AM
Reposted
Very exciting! Thanks to Cell Press, Arun Shukla, and the team for the Preview article on our recent advances in uncovering the structure of LYCHOS/GPR155!

www.cell.com/cell/abstrac...
Bound by the love for cholesterol: A transporter meets a GPCR
In a recent issue of Nature, Bayly-Jones et al. report the cryo-EM structures of a lysosomal cholesterol sensor, LYCHOS, also known as GPR155, which reveals a unique fusion of a plant auxin-transporte...
www.cell.com
November 14, 2024 at 7:46 PM